PortalPublikationenUse of neutrophil count in early diagnosis and risk stratifi...

Use of neutrophil count in early diagnosis and risk stratification of AMI

Standard

Use of neutrophil count in early diagnosis and risk stratification of AMI. / Meissner, Julia; Irfan, Affan; Twerenbold, Raphael; Mueller, Sandra; Reiter, Miriam; Haaf, Philip; Reichlin, Tobias; Schaub, Nora; Winkler, Katrin; Pfister, Otmar; Heinisch, Corinna; Mueller, Christian.

in: AM J MED, Jahrgang 124, Nr. 6, 06.2011, S. 534-42.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Meissner, J, Irfan, A, Twerenbold, R, Mueller, S, Reiter, M, Haaf, P, Reichlin, T, Schaub, N, Winkler, K, Pfister, O, Heinisch, C & Mueller, C 2011, 'Use of neutrophil count in early diagnosis and risk stratification of AMI', AM J MED, Jg. 124, Nr. 6, S. 534-42. https://doi.org/10.1016/j.amjmed.2010.10.023

APA

Meissner, J., Irfan, A., Twerenbold, R., Mueller, S., Reiter, M., Haaf, P., Reichlin, T., Schaub, N., Winkler, K., Pfister, O., Heinisch, C., & Mueller, C. (2011). Use of neutrophil count in early diagnosis and risk stratification of AMI. AM J MED, 124(6), 534-42. https://doi.org/10.1016/j.amjmed.2010.10.023

Vancouver

Meissner J, Irfan A, Twerenbold R, Mueller S, Reiter M, Haaf P et al. Use of neutrophil count in early diagnosis and risk stratification of AMI. AM J MED. 2011 Jun;124(6):534-42. https://doi.org/10.1016/j.amjmed.2010.10.023

Bibtex

@article{281c4dd3666d4303a239fc34dee853e0,
title = "Use of neutrophil count in early diagnosis and risk stratification of AMI",
abstract = "BACKGROUND: Neutrophils are rapidly released into the circulation upon acute stress such as trauma or acute myocardial infarction (AMI). We hypothesized that neutrophil count might provide incremental value in the early diagnosis and risk stratification of AMI.METHODS: We conducted a prospective observational multicenter study to examine the diagnostic accuracy of the combination of neutrophil count and cardiac troponin T from 1125 consecutive patients who presented to the Emergency Department with symptoms suggestive of acute myocardial infarction. The final diagnosis was adjudicated by 2 independent cardiologists.RESULTS: Neutrophil count was higher in patients with acute myocardial infarction compared with other diagnoses (median 6.7 vs. 5.0×10(9)/L, respectively, P <.001). The accuracy of the neutrophil count for diagnosing acute myocardial infarction, quantified by the area under the receiver operating characteristic curve (AUC) was 0.69, which was significantly lower than that of cardiac troponin T (AUC 0.89, P <.001). The combination of the neutrophil count and cardiac troponin T did not improve the early diagnosis of acute myocardial infarction versus cardiac troponin T alone (P=.79). The prognostic accuracy of neutrophil count for death and AMI was significantly lower than that of cardiac troponin T. However, patients in the highest tertile of neutrophil count had a significantly increased risk of death and AMI at 90 and 360 days compared with patients in the lowest tertile (hazard ratios 2.47 [95% confidence interval, 1.63-3.72] and 2.28 [95% confidence interval, 1.55-3.36], respectively).CONCLUSION: The neutrophil count does not improve the early diagnosis of AMI in patients presenting with chest pain but identifies patients at increased risk of death.",
keywords = "Aged, Aged, 80 and over, Angina Pectoris/etiology, Area Under Curve, Biomarkers/blood, Early Diagnosis, Female, Humans, Leukocyte Count, Lymphocyte Count, Male, Middle Aged, Myocardial Infarction/blood, Neutrophils, Predictive Value of Tests, Proportional Hazards Models, Prospective Studies, ROC Curve, Reproducibility of Results, Risk Assessment, Risk Factors, Troponin T/blood",
author = "Julia Meissner and Affan Irfan and Raphael Twerenbold and Sandra Mueller and Miriam Reiter and Philip Haaf and Tobias Reichlin and Nora Schaub and Katrin Winkler and Otmar Pfister and Corinna Heinisch and Christian Mueller",
note = "Copyright {\textcopyright} 2011 Elsevier Inc. All rights reserved.",
year = "2011",
month = jun,
doi = "10.1016/j.amjmed.2010.10.023",
language = "English",
volume = "124",
pages = "534--42",
journal = "AM J MED",
issn = "0002-9343",
publisher = "Elsevier Inc.",
number = "6",

}

RIS

TY - JOUR

T1 - Use of neutrophil count in early diagnosis and risk stratification of AMI

AU - Meissner, Julia

AU - Irfan, Affan

AU - Twerenbold, Raphael

AU - Mueller, Sandra

AU - Reiter, Miriam

AU - Haaf, Philip

AU - Reichlin, Tobias

AU - Schaub, Nora

AU - Winkler, Katrin

AU - Pfister, Otmar

AU - Heinisch, Corinna

AU - Mueller, Christian

N1 - Copyright © 2011 Elsevier Inc. All rights reserved.

PY - 2011/6

Y1 - 2011/6

N2 - BACKGROUND: Neutrophils are rapidly released into the circulation upon acute stress such as trauma or acute myocardial infarction (AMI). We hypothesized that neutrophil count might provide incremental value in the early diagnosis and risk stratification of AMI.METHODS: We conducted a prospective observational multicenter study to examine the diagnostic accuracy of the combination of neutrophil count and cardiac troponin T from 1125 consecutive patients who presented to the Emergency Department with symptoms suggestive of acute myocardial infarction. The final diagnosis was adjudicated by 2 independent cardiologists.RESULTS: Neutrophil count was higher in patients with acute myocardial infarction compared with other diagnoses (median 6.7 vs. 5.0×10(9)/L, respectively, P <.001). The accuracy of the neutrophil count for diagnosing acute myocardial infarction, quantified by the area under the receiver operating characteristic curve (AUC) was 0.69, which was significantly lower than that of cardiac troponin T (AUC 0.89, P <.001). The combination of the neutrophil count and cardiac troponin T did not improve the early diagnosis of acute myocardial infarction versus cardiac troponin T alone (P=.79). The prognostic accuracy of neutrophil count for death and AMI was significantly lower than that of cardiac troponin T. However, patients in the highest tertile of neutrophil count had a significantly increased risk of death and AMI at 90 and 360 days compared with patients in the lowest tertile (hazard ratios 2.47 [95% confidence interval, 1.63-3.72] and 2.28 [95% confidence interval, 1.55-3.36], respectively).CONCLUSION: The neutrophil count does not improve the early diagnosis of AMI in patients presenting with chest pain but identifies patients at increased risk of death.

AB - BACKGROUND: Neutrophils are rapidly released into the circulation upon acute stress such as trauma or acute myocardial infarction (AMI). We hypothesized that neutrophil count might provide incremental value in the early diagnosis and risk stratification of AMI.METHODS: We conducted a prospective observational multicenter study to examine the diagnostic accuracy of the combination of neutrophil count and cardiac troponin T from 1125 consecutive patients who presented to the Emergency Department with symptoms suggestive of acute myocardial infarction. The final diagnosis was adjudicated by 2 independent cardiologists.RESULTS: Neutrophil count was higher in patients with acute myocardial infarction compared with other diagnoses (median 6.7 vs. 5.0×10(9)/L, respectively, P <.001). The accuracy of the neutrophil count for diagnosing acute myocardial infarction, quantified by the area under the receiver operating characteristic curve (AUC) was 0.69, which was significantly lower than that of cardiac troponin T (AUC 0.89, P <.001). The combination of the neutrophil count and cardiac troponin T did not improve the early diagnosis of acute myocardial infarction versus cardiac troponin T alone (P=.79). The prognostic accuracy of neutrophil count for death and AMI was significantly lower than that of cardiac troponin T. However, patients in the highest tertile of neutrophil count had a significantly increased risk of death and AMI at 90 and 360 days compared with patients in the lowest tertile (hazard ratios 2.47 [95% confidence interval, 1.63-3.72] and 2.28 [95% confidence interval, 1.55-3.36], respectively).CONCLUSION: The neutrophil count does not improve the early diagnosis of AMI in patients presenting with chest pain but identifies patients at increased risk of death.

KW - Aged

KW - Aged, 80 and over

KW - Angina Pectoris/etiology

KW - Area Under Curve

KW - Biomarkers/blood

KW - Early Diagnosis

KW - Female

KW - Humans

KW - Leukocyte Count

KW - Lymphocyte Count

KW - Male

KW - Middle Aged

KW - Myocardial Infarction/blood

KW - Neutrophils

KW - Predictive Value of Tests

KW - Proportional Hazards Models

KW - Prospective Studies

KW - ROC Curve

KW - Reproducibility of Results

KW - Risk Assessment

KW - Risk Factors

KW - Troponin T/blood

U2 - 10.1016/j.amjmed.2010.10.023

DO - 10.1016/j.amjmed.2010.10.023

M3 - SCORING: Journal article

C2 - 21507368

VL - 124

SP - 534

EP - 542

JO - AM J MED

JF - AM J MED

SN - 0002-9343

IS - 6

ER -