PortalPublikationenTransplanted mesoangioblasts require macrophage IL-10 for su...

Transplanted mesoangioblasts require macrophage IL-10 for survival in a mouse model of muscle injury

Standard

Transplanted mesoangioblasts require macrophage IL-10 for survival in a mouse model of muscle injury. / Bosurgi, L.; Corna, G.; Vezzoli, M.; Touvier, T.; Cossu, G.; Manfredi, A.A.; Brunelli, S.; Rovere-Querini, P.

in: J IMMUNOL, Jahrgang 188, Nr. 12, 2012, S. 6267-6277.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Bosurgi, L, Corna, G, Vezzoli, M, Touvier, T, Cossu, G, Manfredi, AA, Brunelli, S & Rovere-Querini, P 2012, 'Transplanted mesoangioblasts require macrophage IL-10 for survival in a mouse model of muscle injury', J IMMUNOL, Jg. 188, Nr. 12, S. 6267-6277. https://doi.org/10.4049/jimmunol.1102680

APA

Bosurgi, L., Corna, G., Vezzoli, M., Touvier, T., Cossu, G., Manfredi, A. A., Brunelli, S., & Rovere-Querini, P. (2012). Transplanted mesoangioblasts require macrophage IL-10 for survival in a mouse model of muscle injury. J IMMUNOL, 188(12), 6267-6277. https://doi.org/10.4049/jimmunol.1102680

Vancouver

Bosurgi L, Corna G, Vezzoli M, Touvier T, Cossu G, Manfredi AA et al. Transplanted mesoangioblasts require macrophage IL-10 for survival in a mouse model of muscle injury. J IMMUNOL. 2012;188(12):6267-6277. https://doi.org/10.4049/jimmunol.1102680

Bibtex

@article{ba32a903286c4bd2b4364c92c947b659,
title = "Transplanted mesoangioblasts require macrophage IL-10 for survival in a mouse model of muscle injury",
abstract = "The aim of this study was to verify whether macrophages influence the fate of transplanted mesoangioblasts--vessel-associated myogenic precursors--in a model of sterile toxin-induced skeletal muscle injury. We have observed that in the absence of macrophages, transplanted mesoangioblasts do not yield novel fibers. Macrophages retrieved from skeletal muscles at various times after injury display features that resemble those of immunoregulatory macrophages. Indeed, they secrete IL-10 and express CD206 and CD163 membrane receptors and high amounts of arginase I. We have reconstituted the muscle-associated macrophage population by injecting polarized macrophages before mesoangioblast injection: alternatively activated, immunoregulatory macrophages only support mesoangioblast survival and function. This action depends on the secretion of IL-10 in the tissue. Our results reveal an unanticipated role for tissue macrophages in mesoangioblast function. Consequently, the treatment of muscle disorders with mesoangioblasts should take into consideration coexisting inflammatory pathways, whose activation may prove crucial for its success.",
author = "L. Bosurgi and G. Corna and M. Vezzoli and T. Touvier and G. Cossu and A.A. Manfredi and S. Brunelli and P. Rovere-Querini",
year = "2012",
doi = "10.4049/jimmunol.1102680",
language = "English",
volume = "188",
pages = "6267--6277",
journal = "J IMMUNOL",
issn = "0022-1767",
publisher = "American Association of Immunologists",
number = "12",

}

RIS

TY - JOUR

T1 - Transplanted mesoangioblasts require macrophage IL-10 for survival in a mouse model of muscle injury

AU - Bosurgi, L.

AU - Corna, G.

AU - Vezzoli, M.

AU - Touvier, T.

AU - Cossu, G.

AU - Manfredi, A.A.

AU - Brunelli, S.

AU - Rovere-Querini, P.

PY - 2012

Y1 - 2012

N2 - The aim of this study was to verify whether macrophages influence the fate of transplanted mesoangioblasts--vessel-associated myogenic precursors--in a model of sterile toxin-induced skeletal muscle injury. We have observed that in the absence of macrophages, transplanted mesoangioblasts do not yield novel fibers. Macrophages retrieved from skeletal muscles at various times after injury display features that resemble those of immunoregulatory macrophages. Indeed, they secrete IL-10 and express CD206 and CD163 membrane receptors and high amounts of arginase I. We have reconstituted the muscle-associated macrophage population by injecting polarized macrophages before mesoangioblast injection: alternatively activated, immunoregulatory macrophages only support mesoangioblast survival and function. This action depends on the secretion of IL-10 in the tissue. Our results reveal an unanticipated role for tissue macrophages in mesoangioblast function. Consequently, the treatment of muscle disorders with mesoangioblasts should take into consideration coexisting inflammatory pathways, whose activation may prove crucial for its success.

AB - The aim of this study was to verify whether macrophages influence the fate of transplanted mesoangioblasts--vessel-associated myogenic precursors--in a model of sterile toxin-induced skeletal muscle injury. We have observed that in the absence of macrophages, transplanted mesoangioblasts do not yield novel fibers. Macrophages retrieved from skeletal muscles at various times after injury display features that resemble those of immunoregulatory macrophages. Indeed, they secrete IL-10 and express CD206 and CD163 membrane receptors and high amounts of arginase I. We have reconstituted the muscle-associated macrophage population by injecting polarized macrophages before mesoangioblast injection: alternatively activated, immunoregulatory macrophages only support mesoangioblast survival and function. This action depends on the secretion of IL-10 in the tissue. Our results reveal an unanticipated role for tissue macrophages in mesoangioblast function. Consequently, the treatment of muscle disorders with mesoangioblasts should take into consideration coexisting inflammatory pathways, whose activation may prove crucial for its success.

UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-84862629389&partnerID=MN8TOARS

U2 - 10.4049/jimmunol.1102680

DO - 10.4049/jimmunol.1102680

M3 - SCORING: Journal article

C2 - 22573810

VL - 188

SP - 6267

EP - 6277

JO - J IMMUNOL

JF - J IMMUNOL

SN - 0022-1767

IS - 12

ER -