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The role of the vagus nerve

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The role of the vagus nerve : modulation of the inflammatory reaction in murine polymicrobial sepsis. / Kessler, Wolfram; Diedrich, Stephan; Menges, Pia; Ebker, Tobias; Nielson, Michael; Partecke, Lars Ivo; Traeger, Tobias; Cziupka, Katharina; van der Linde, Julia; Puls, Ralf; Busemann, Alexandra; Heidecke, Claus-Dieter; Maier, Stefan.

in: MEDIAT INFLAMM, Jahrgang 2012, 2012, S. 467620.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Kessler, W, Diedrich, S, Menges, P, Ebker, T, Nielson, M, Partecke, LI, Traeger, T, Cziupka, K, van der Linde, J, Puls, R, Busemann, A, Heidecke, C-D & Maier, S 2012, 'The role of the vagus nerve: modulation of the inflammatory reaction in murine polymicrobial sepsis', MEDIAT INFLAMM, Jg. 2012, S. 467620. https://doi.org/10.1155/2012/467620

APA

Kessler, W., Diedrich, S., Menges, P., Ebker, T., Nielson, M., Partecke, L. I., Traeger, T., Cziupka, K., van der Linde, J., Puls, R., Busemann, A., Heidecke, C-D., & Maier, S. (2012). The role of the vagus nerve: modulation of the inflammatory reaction in murine polymicrobial sepsis. MEDIAT INFLAMM, 2012, 467620. https://doi.org/10.1155/2012/467620

Vancouver

Kessler W, Diedrich S, Menges P, Ebker T, Nielson M, Partecke LI et al. The role of the vagus nerve: modulation of the inflammatory reaction in murine polymicrobial sepsis. MEDIAT INFLAMM. 2012;2012:467620. https://doi.org/10.1155/2012/467620

Bibtex

@article{3b312ed6b96e44b6a28ed05eafca6e73,
title = "The role of the vagus nerve: modulation of the inflammatory reaction in murine polymicrobial sepsis",
abstract = "The particular importance of the vagus nerve for the pathophysiology of peritonitis becomes more and more apparent. In this work we provide evidence for the vagal modulation of inflammation in the murine model of colon ascendens stent peritonitis (CASP). Vagotomy significantly increases mortality in polymicrobial sepsis. This effect is not accounted for by the dilatation of gastric volume following vagotomy. As the stimulation of cholinergic receptors by nicotine has no therapeutic effect, the lack of nicotine is also not the reason for the reduced survival rate. In fact, increased septic mortality is a consequence of the absent modulating influence of the vagus nerve on the immune system: we detected significantly elevated serum corticosterone levels in vagotomised mice 24 h following CASP and a decreased ex vivo TNF-alpha secretion of Kupffer cells upon stimulation with LPS. In conclusion, the vagus nerve has a modulating influence in polymicrobial sepsis by attenuating the immune dysregulation.",
keywords = "Animals, Corticosterone, Female, Inflammation, Kupffer Cells, Lipopolysaccharides, Magnetic Resonance Imaging, Mice, Mice, Inbred C57BL, Nicotine, Osmosis, Receptors, Cholinergic, Sepsis, Stents, Time Factors, Tumor Necrosis Factor-alpha, Vagus Nerve",
author = "Wolfram Kessler and Stephan Diedrich and Pia Menges and Tobias Ebker and Michael Nielson and Partecke, {Lars Ivo} and Tobias Traeger and Katharina Cziupka and {van der Linde}, Julia and Ralf Puls and Alexandra Busemann and Claus-Dieter Heidecke and Stefan Maier",
year = "2012",
doi = "10.1155/2012/467620",
language = "English",
volume = "2012",
pages = "467620",
journal = "MEDIAT INFLAMM",
issn = "0962-9351",
publisher = "Hindawi Publishing Corporation",

}

RIS

TY - JOUR

T1 - The role of the vagus nerve

T2 - modulation of the inflammatory reaction in murine polymicrobial sepsis

AU - Kessler, Wolfram

AU - Diedrich, Stephan

AU - Menges, Pia

AU - Ebker, Tobias

AU - Nielson, Michael

AU - Partecke, Lars Ivo

AU - Traeger, Tobias

AU - Cziupka, Katharina

AU - van der Linde, Julia

AU - Puls, Ralf

AU - Busemann, Alexandra

AU - Heidecke, Claus-Dieter

AU - Maier, Stefan

PY - 2012

Y1 - 2012

N2 - The particular importance of the vagus nerve for the pathophysiology of peritonitis becomes more and more apparent. In this work we provide evidence for the vagal modulation of inflammation in the murine model of colon ascendens stent peritonitis (CASP). Vagotomy significantly increases mortality in polymicrobial sepsis. This effect is not accounted for by the dilatation of gastric volume following vagotomy. As the stimulation of cholinergic receptors by nicotine has no therapeutic effect, the lack of nicotine is also not the reason for the reduced survival rate. In fact, increased septic mortality is a consequence of the absent modulating influence of the vagus nerve on the immune system: we detected significantly elevated serum corticosterone levels in vagotomised mice 24 h following CASP and a decreased ex vivo TNF-alpha secretion of Kupffer cells upon stimulation with LPS. In conclusion, the vagus nerve has a modulating influence in polymicrobial sepsis by attenuating the immune dysregulation.

AB - The particular importance of the vagus nerve for the pathophysiology of peritonitis becomes more and more apparent. In this work we provide evidence for the vagal modulation of inflammation in the murine model of colon ascendens stent peritonitis (CASP). Vagotomy significantly increases mortality in polymicrobial sepsis. This effect is not accounted for by the dilatation of gastric volume following vagotomy. As the stimulation of cholinergic receptors by nicotine has no therapeutic effect, the lack of nicotine is also not the reason for the reduced survival rate. In fact, increased septic mortality is a consequence of the absent modulating influence of the vagus nerve on the immune system: we detected significantly elevated serum corticosterone levels in vagotomised mice 24 h following CASP and a decreased ex vivo TNF-alpha secretion of Kupffer cells upon stimulation with LPS. In conclusion, the vagus nerve has a modulating influence in polymicrobial sepsis by attenuating the immune dysregulation.

KW - Animals

KW - Corticosterone

KW - Female

KW - Inflammation

KW - Kupffer Cells

KW - Lipopolysaccharides

KW - Magnetic Resonance Imaging

KW - Mice

KW - Mice, Inbred C57BL

KW - Nicotine

KW - Osmosis

KW - Receptors, Cholinergic

KW - Sepsis

KW - Stents

KW - Time Factors

KW - Tumor Necrosis Factor-alpha

KW - Vagus Nerve

U2 - 10.1155/2012/467620

DO - 10.1155/2012/467620

M3 - SCORING: Journal article

C2 - 22547905

VL - 2012

SP - 467620

JO - MEDIAT INFLAMM

JF - MEDIAT INFLAMM

SN - 0962-9351

ER -