The role of sleep and sleep deprivation in consolidating fear memories
Standard
The role of sleep and sleep deprivation in consolidating fear memories. / Menz, M M; Rihm, JS; Salari, N; Born, J; Kalisch, R; Pape, H C; Marshall, L; Büchel, C.
in: NEUROIMAGE, Jahrgang 75, 15.07.2013, S. 87-96.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - The role of sleep and sleep deprivation in consolidating fear memories
AU - Menz, M M
AU - Rihm, JS
AU - Salari, N
AU - Born, J
AU - Kalisch, R
AU - Pape, H C
AU - Marshall, L
AU - Büchel, C
N1 - Copyright © 2013 Elsevier Inc. All rights reserved.
PY - 2013/7/15
Y1 - 2013/7/15
N2 - Sleep, in particular REM sleep, has been shown to improve the consolidation of emotional memories. Here, we investigated the role of sleep and sleep deprivation on the consolidation of fear memories and underlying neuronal mechanisms. We employed a Pavlovian fear conditioning paradigm either followed by a night of polysomnographically monitored sleep, or wakefulness in forty healthy participants. Recall of learned fear was better after sleep, as indicated by stronger explicitly perceived anxiety and autonomous nervous responses. These effects were positively correlated with the preceding time spent in REM sleep and paralleled by activation of the basolateral amygdala. These findings suggest REM sleep-associated consolidation of fear memory in the human amygdala. In view of the critical participation of fear learning mechanisms in the etiology of anxiety and post-traumatic stress disorder, deprivation of REM sleep after exposure to distressing events is an interesting target for further investigation.
AB - Sleep, in particular REM sleep, has been shown to improve the consolidation of emotional memories. Here, we investigated the role of sleep and sleep deprivation on the consolidation of fear memories and underlying neuronal mechanisms. We employed a Pavlovian fear conditioning paradigm either followed by a night of polysomnographically monitored sleep, or wakefulness in forty healthy participants. Recall of learned fear was better after sleep, as indicated by stronger explicitly perceived anxiety and autonomous nervous responses. These effects were positively correlated with the preceding time spent in REM sleep and paralleled by activation of the basolateral amygdala. These findings suggest REM sleep-associated consolidation of fear memory in the human amygdala. In view of the critical participation of fear learning mechanisms in the etiology of anxiety and post-traumatic stress disorder, deprivation of REM sleep after exposure to distressing events is an interesting target for further investigation.
KW - Adult
KW - Conditioning, Classical
KW - Fear
KW - Humans
KW - Male
KW - Memory
KW - Polysomnography
KW - Sleep
KW - Sleep Deprivation
KW - Sleep, REM
KW - Young Adult
U2 - 10.1016/j.neuroimage.2013.03.001
DO - 10.1016/j.neuroimage.2013.03.001
M3 - SCORING: Journal article
C2 - 23501052
VL - 75
SP - 87
EP - 96
JO - NEUROIMAGE
JF - NEUROIMAGE
SN - 1053-8119
ER -