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The intestinal microbiota determines the colitis-inducing potential of T-bet-deficient Th cells in mice

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The intestinal microbiota determines the colitis-inducing potential of T-bet-deficient Th cells in mice. / Zimmermann, Jakob; Durek, Pawel; Kühl, Anja Andrea; Schattenberg, Florian; Maschmeyer, Patrick; Siracusa, Francesco; Lehmann, Katrin; Westendorf, Kerstin; Weber, Melanie; Riedel, René; Müller, Susann; Radbruch, Andreas; Chang, Hyun-Dong.

in: EUR J IMMUNOL, Jahrgang 48, Nr. 1, 01.2018, S. 161-167.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Zimmermann, J, Durek, P, Kühl, AA, Schattenberg, F, Maschmeyer, P, Siracusa, F, Lehmann, K, Westendorf, K, Weber, M, Riedel, R, Müller, S, Radbruch, A & Chang, H-D 2018, 'The intestinal microbiota determines the colitis-inducing potential of T-bet-deficient Th cells in mice', EUR J IMMUNOL, Jg. 48, Nr. 1, S. 161-167. https://doi.org/10.1002/eji.201747100

APA

Zimmermann, J., Durek, P., Kühl, A. A., Schattenberg, F., Maschmeyer, P., Siracusa, F., Lehmann, K., Westendorf, K., Weber, M., Riedel, R., Müller, S., Radbruch, A., & Chang, H-D. (2018). The intestinal microbiota determines the colitis-inducing potential of T-bet-deficient Th cells in mice. EUR J IMMUNOL, 48(1), 161-167. https://doi.org/10.1002/eji.201747100

Vancouver

Zimmermann J, Durek P, Kühl AA, Schattenberg F, Maschmeyer P, Siracusa F et al. The intestinal microbiota determines the colitis-inducing potential of T-bet-deficient Th cells in mice. EUR J IMMUNOL. 2018 Jan;48(1):161-167. https://doi.org/10.1002/eji.201747100

Bibtex

@article{85b5f687cfab4b47bbab89b54b76b9a1,
title = "The intestinal microbiota determines the colitis-inducing potential of T-bet-deficient Th cells in mice",
abstract = "Conflicting evidence has been provided as to whether induction of intestinal inflammation by adoptive transfer of na{\"i}ve T cells into Rag-/- mice requires expression of the transcription factor T-bet by the T cells. Here, we formally show that the intestinal microbiota composition of the Rag-/- recipient determines whether or not T-bet-deficient Th cells can induce colitis and we have resolved the differences of the two microbiomes, permissive or non-permissive to T-bet-independent colitis. Our data highlight the dominance of the microbiota over particular T cell differentiation programs in the pathogenesis of chronic intestinal inflammation.",
keywords = "Adoptive Transfer/methods, Animals, Cell Differentiation/immunology, Colitis/genetics, Disease Models, Animal, Gastrointestinal Microbiome/immunology, Homeodomain Proteins/genetics, Inflammation/immunology, Lymphocyte Activation/immunology, Mice, Mice, Inbred C57BL, Mice, Knockout, T-Box Domain Proteins/genetics, T-Lymphocyte Subsets/immunology, T-Lymphocytes, Helper-Inducer/immunology",
author = "Jakob Zimmermann and Pawel Durek and K{\"u}hl, {Anja Andrea} and Florian Schattenberg and Patrick Maschmeyer and Francesco Siracusa and Katrin Lehmann and Kerstin Westendorf and Melanie Weber and Ren{\'e} Riedel and Susann M{\"u}ller and Andreas Radbruch and Hyun-Dong Chang",
note = "{\textcopyright} 2017 The Authors. European Journal of Immunology published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",
year = "2018",
month = jan,
doi = "10.1002/eji.201747100",
language = "English",
volume = "48",
pages = "161--167",
journal = "EUR J IMMUNOL",
issn = "0014-2980",
publisher = "Wiley-VCH Verlag GmbH",
number = "1",

}

RIS

TY - JOUR

T1 - The intestinal microbiota determines the colitis-inducing potential of T-bet-deficient Th cells in mice

AU - Zimmermann, Jakob

AU - Durek, Pawel

AU - Kühl, Anja Andrea

AU - Schattenberg, Florian

AU - Maschmeyer, Patrick

AU - Siracusa, Francesco

AU - Lehmann, Katrin

AU - Westendorf, Kerstin

AU - Weber, Melanie

AU - Riedel, René

AU - Müller, Susann

AU - Radbruch, Andreas

AU - Chang, Hyun-Dong

N1 - © 2017 The Authors. European Journal of Immunology published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PY - 2018/1

Y1 - 2018/1

N2 - Conflicting evidence has been provided as to whether induction of intestinal inflammation by adoptive transfer of naïve T cells into Rag-/- mice requires expression of the transcription factor T-bet by the T cells. Here, we formally show that the intestinal microbiota composition of the Rag-/- recipient determines whether or not T-bet-deficient Th cells can induce colitis and we have resolved the differences of the two microbiomes, permissive or non-permissive to T-bet-independent colitis. Our data highlight the dominance of the microbiota over particular T cell differentiation programs in the pathogenesis of chronic intestinal inflammation.

AB - Conflicting evidence has been provided as to whether induction of intestinal inflammation by adoptive transfer of naïve T cells into Rag-/- mice requires expression of the transcription factor T-bet by the T cells. Here, we formally show that the intestinal microbiota composition of the Rag-/- recipient determines whether or not T-bet-deficient Th cells can induce colitis and we have resolved the differences of the two microbiomes, permissive or non-permissive to T-bet-independent colitis. Our data highlight the dominance of the microbiota over particular T cell differentiation programs in the pathogenesis of chronic intestinal inflammation.

KW - Adoptive Transfer/methods

KW - Animals

KW - Cell Differentiation/immunology

KW - Colitis/genetics

KW - Disease Models, Animal

KW - Gastrointestinal Microbiome/immunology

KW - Homeodomain Proteins/genetics

KW - Inflammation/immunology

KW - Lymphocyte Activation/immunology

KW - Mice

KW - Mice, Inbred C57BL

KW - Mice, Knockout

KW - T-Box Domain Proteins/genetics

KW - T-Lymphocyte Subsets/immunology

KW - T-Lymphocytes, Helper-Inducer/immunology

U2 - 10.1002/eji.201747100

DO - 10.1002/eji.201747100

M3 - SCORING: Journal article

C2 - 28875499

VL - 48

SP - 161

EP - 167

JO - EUR J IMMUNOL

JF - EUR J IMMUNOL

SN - 0014-2980

IS - 1

ER -