Suicidal ideation in a European Huntington's disease population
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Suicidal ideation in a European Huntington's disease population. / Hubers, Anna A M; van Duijn, Erik; Roos, Raymund A C; Craufurd, David; Rickards, Hugh; Bernhard Landwehrmeyer, G; van der Mast, Rose C; Giltay, Erik J; REGISTRY Investigators of the European Huntington’s Disease Network.
in: J AFFECT DISORDERS, Jahrgang 151, Nr. 1, 10.2013, S. 248-58.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Suicidal ideation in a European Huntington's disease population
AU - Hubers, Anna A M
AU - van Duijn, Erik
AU - Roos, Raymund A C
AU - Craufurd, David
AU - Rickards, Hugh
AU - Bernhard Landwehrmeyer, G
AU - van der Mast, Rose C
AU - Giltay, Erik J
AU - REGISTRY Investigators of the European Huntington’s Disease Network
N1 - © 2013 Elsevier B.V. All rights reserved.
PY - 2013/10
Y1 - 2013/10
N2 - BACKGROUND: Previous studies indicate increased prevalences of suicidal ideation, suicide attempts, and completed suicide in Huntington's disease (HD) compared with the general population. This study investigates correlates and predictors of suicidal ideation in HD.METHODS: The study cohort consisted of 2106 HD mutation carriers, all participating in the REGISTRY study of the European Huntington's Disease Network. Of the 1937 participants without suicidal ideation at baseline, 945 had one or more follow-up measurements. Participants were assessed for suicidal ideation by the behavioural subscale of the Unified Huntington's Disease Rating Scale (UHDRS). Correlates of suicidal ideation were analyzed using logistic regression analysis and predictors were analyzed using Cox regression analysis.RESULTS: At baseline, 169 (8.0%) mutation carriers endorsed suicidal ideation. Disease duration (odds ratio [OR]=0.96; 95% confidence interval [CI]: 0.9-1.0), anxiety (OR=2.14; 95%CI: 1.4-3.3), aggression (OR=2.41; 95%CI: 1.5-3.8), a previous suicide attempt (OR=3.95; 95%CI: 2.4-6.6), and a depressed mood (OR=13.71; 95%CI: 6.7-28.0) were independently correlated to suicidal ideation at baseline. The 4-year cumulative incidence of suicidal ideation was 9.9%. Longitudinally, the presence of a depressed mood (hazard ratio [HR]=2.05; 95%CI: 1.1-4.0) and use of benzodiazepines (HR=2.44; 95%CI: 1.2-5.0) at baseline were independent predictors of incident suicidal ideation, whereas a previous suicide attempt was not predictive.LIMITATIONS: As suicidal ideation was assessed by only one item, and participants were a selection of all HD mutation carriers, the prevalence of suicidal ideation was likely underestimated.CONCLUSIONS: Suicidal ideation in HD frequently occurs. Assessment of suicidal ideation is a priority in mutation carriers with a depressed mood and in those using benzodiazepines.
AB - BACKGROUND: Previous studies indicate increased prevalences of suicidal ideation, suicide attempts, and completed suicide in Huntington's disease (HD) compared with the general population. This study investigates correlates and predictors of suicidal ideation in HD.METHODS: The study cohort consisted of 2106 HD mutation carriers, all participating in the REGISTRY study of the European Huntington's Disease Network. Of the 1937 participants without suicidal ideation at baseline, 945 had one or more follow-up measurements. Participants were assessed for suicidal ideation by the behavioural subscale of the Unified Huntington's Disease Rating Scale (UHDRS). Correlates of suicidal ideation were analyzed using logistic regression analysis and predictors were analyzed using Cox regression analysis.RESULTS: At baseline, 169 (8.0%) mutation carriers endorsed suicidal ideation. Disease duration (odds ratio [OR]=0.96; 95% confidence interval [CI]: 0.9-1.0), anxiety (OR=2.14; 95%CI: 1.4-3.3), aggression (OR=2.41; 95%CI: 1.5-3.8), a previous suicide attempt (OR=3.95; 95%CI: 2.4-6.6), and a depressed mood (OR=13.71; 95%CI: 6.7-28.0) were independently correlated to suicidal ideation at baseline. The 4-year cumulative incidence of suicidal ideation was 9.9%. Longitudinally, the presence of a depressed mood (hazard ratio [HR]=2.05; 95%CI: 1.1-4.0) and use of benzodiazepines (HR=2.44; 95%CI: 1.2-5.0) at baseline were independent predictors of incident suicidal ideation, whereas a previous suicide attempt was not predictive.LIMITATIONS: As suicidal ideation was assessed by only one item, and participants were a selection of all HD mutation carriers, the prevalence of suicidal ideation was likely underestimated.CONCLUSIONS: Suicidal ideation in HD frequently occurs. Assessment of suicidal ideation is a priority in mutation carriers with a depressed mood and in those using benzodiazepines.
KW - Depression
KW - Europe
KW - Female
KW - Heterozygote
KW - Humans
KW - Huntington Disease
KW - Male
KW - Middle Aged
KW - Prevalence
KW - Proportional Hazards Models
KW - Psychiatric Status Rating Scales
KW - Psychological Tests
KW - Suicidal Ideation
KW - Suicide, Attempted
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1016/j.jad.2013.06.001
DO - 10.1016/j.jad.2013.06.001
M3 - SCORING: Journal article
C2 - 23876196
VL - 151
SP - 248
EP - 258
JO - J AFFECT DISORDERS
JF - J AFFECT DISORDERS
SN - 0165-0327
IS - 1
ER -
