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Substrate characterization and catheter ablation for monomorphic ventricular tachycardia in patients with apical hypertrophic cardiomyopathy

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Substrate characterization and catheter ablation for monomorphic ventricular tachycardia in patients with apical hypertrophic cardiomyopathy. / Inada, Keiichi; Seiler, Jens; Roberts-Thomson, Kurt C; Steven, Daniel; Rosman, Jonathan; John, Roy M; Sobieszczyk, Piotr; Stevenson, William G; Tedrow, Usha B.

in: J CARDIOVASC ELECTR, Jahrgang 22, Nr. 1, 01.2011, S. 41-48.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Inada, K, Seiler, J, Roberts-Thomson, KC, Steven, D, Rosman, J, John, RM, Sobieszczyk, P, Stevenson, WG & Tedrow, UB 2011, 'Substrate characterization and catheter ablation for monomorphic ventricular tachycardia in patients with apical hypertrophic cardiomyopathy', J CARDIOVASC ELECTR, Jg. 22, Nr. 1, S. 41-48. https://doi.org/10.1111/j.1540-8167.2010.01875.x

APA

Inada, K., Seiler, J., Roberts-Thomson, K. C., Steven, D., Rosman, J., John, R. M., Sobieszczyk, P., Stevenson, W. G., & Tedrow, U. B. (2011). Substrate characterization and catheter ablation for monomorphic ventricular tachycardia in patients with apical hypertrophic cardiomyopathy. J CARDIOVASC ELECTR, 22(1), 41-48. https://doi.org/10.1111/j.1540-8167.2010.01875.x

Vancouver

Inada K, Seiler J, Roberts-Thomson KC, Steven D, Rosman J, John RM et al. Substrate characterization and catheter ablation for monomorphic ventricular tachycardia in patients with apical hypertrophic cardiomyopathy. J CARDIOVASC ELECTR. 2011 Jan;22(1):41-48. https://doi.org/10.1111/j.1540-8167.2010.01875.x

Bibtex

@article{f3c9740f49104681a880d927ae50b347,
title = "Substrate characterization and catheter ablation for monomorphic ventricular tachycardia in patients with apical hypertrophic cardiomyopathy",
abstract = "UNLABELLED: VT Ablation in Apical Hypertrophic Cardiomyopathy. INTRODUCTION: Monomorphic ventricular tachycardia (VT) is uncommon in apical hypertrophic cardiomyopathy (HCM). The purpose of this study was to define the substrate and role of catheter ablation for VT in apical HCM.METHODS: Four patients with apical HCM and frequent, drug refractory VT (mean age of 46 ± 10 years, left ventricular [LV] ejection fraction; 54 ± 14%) underwent catheter ablation with the use of electroanatomic mapping. Endocardial mapping was performed in 4 patients and 3 patients underwent epicardial mapping.RESULTS: In 3 patients, VT was related to areas of scar in the apical LV where maximal apical wall thickness ranged from 14.5 to 17.8 mm, and 2 patients had apical aneurysms. Endocardial and epicardial substrate mapping revealed low voltage (<1.5 mV) scar in both endocardial and epicardial LV in 2 and only in the epicardium in 1 patient. Inducible VT was abolished with a combination of endocardial and epicardial ablation in 2 patients, but was ineffective in the third patient who had intramural reentry that required transcoronary ethanol ablation of an obtuse marginal vessel for abolition. The fourth patient had focal nonsustained repetitive VT from right ventricular outflow tract (RVOT), consistent with idiopathic RVOT-VT, that was successfully ablated. During follow-ups of 3-9 months, all patients remained free from VT.CONCLUSION: Monomorphic VT in apical HCM can be due to endocardial, epicardial or intramural reentry in areas of apical scar. Epicardial ablation or transcoronary alcohol ablation is required in some cases.",
keywords = "Adult, Body Surface Potential Mapping, Cardiomyopathy, Hypertrophic/diagnosis, Catheter Ablation/methods, Female, Humans, Male, Middle Aged, Tachycardia, Ventricular/diagnosis, Treatment Outcome",
author = "Keiichi Inada and Jens Seiler and Roberts-Thomson, {Kurt C} and Daniel Steven and Jonathan Rosman and John, {Roy M} and Piotr Sobieszczyk and Stevenson, {William G} and Tedrow, {Usha B}",
note = "{\textcopyright} 2010 Wiley Periodicals, Inc.",
year = "2011",
month = jan,
doi = "10.1111/j.1540-8167.2010.01875.x",
language = "English",
volume = "22",
pages = "41--48",
journal = "J CARDIOVASC ELECTR",
issn = "1045-3873",
publisher = "Wiley-Blackwell",
number = "1",

}

RIS

TY - JOUR

T1 - Substrate characterization and catheter ablation for monomorphic ventricular tachycardia in patients with apical hypertrophic cardiomyopathy

AU - Inada, Keiichi

AU - Seiler, Jens

AU - Roberts-Thomson, Kurt C

AU - Steven, Daniel

AU - Rosman, Jonathan

AU - John, Roy M

AU - Sobieszczyk, Piotr

AU - Stevenson, William G

AU - Tedrow, Usha B

N1 - © 2010 Wiley Periodicals, Inc.

PY - 2011/1

Y1 - 2011/1

N2 - UNLABELLED: VT Ablation in Apical Hypertrophic Cardiomyopathy. INTRODUCTION: Monomorphic ventricular tachycardia (VT) is uncommon in apical hypertrophic cardiomyopathy (HCM). The purpose of this study was to define the substrate and role of catheter ablation for VT in apical HCM.METHODS: Four patients with apical HCM and frequent, drug refractory VT (mean age of 46 ± 10 years, left ventricular [LV] ejection fraction; 54 ± 14%) underwent catheter ablation with the use of electroanatomic mapping. Endocardial mapping was performed in 4 patients and 3 patients underwent epicardial mapping.RESULTS: In 3 patients, VT was related to areas of scar in the apical LV where maximal apical wall thickness ranged from 14.5 to 17.8 mm, and 2 patients had apical aneurysms. Endocardial and epicardial substrate mapping revealed low voltage (<1.5 mV) scar in both endocardial and epicardial LV in 2 and only in the epicardium in 1 patient. Inducible VT was abolished with a combination of endocardial and epicardial ablation in 2 patients, but was ineffective in the third patient who had intramural reentry that required transcoronary ethanol ablation of an obtuse marginal vessel for abolition. The fourth patient had focal nonsustained repetitive VT from right ventricular outflow tract (RVOT), consistent with idiopathic RVOT-VT, that was successfully ablated. During follow-ups of 3-9 months, all patients remained free from VT.CONCLUSION: Monomorphic VT in apical HCM can be due to endocardial, epicardial or intramural reentry in areas of apical scar. Epicardial ablation or transcoronary alcohol ablation is required in some cases.

AB - UNLABELLED: VT Ablation in Apical Hypertrophic Cardiomyopathy. INTRODUCTION: Monomorphic ventricular tachycardia (VT) is uncommon in apical hypertrophic cardiomyopathy (HCM). The purpose of this study was to define the substrate and role of catheter ablation for VT in apical HCM.METHODS: Four patients with apical HCM and frequent, drug refractory VT (mean age of 46 ± 10 years, left ventricular [LV] ejection fraction; 54 ± 14%) underwent catheter ablation with the use of electroanatomic mapping. Endocardial mapping was performed in 4 patients and 3 patients underwent epicardial mapping.RESULTS: In 3 patients, VT was related to areas of scar in the apical LV where maximal apical wall thickness ranged from 14.5 to 17.8 mm, and 2 patients had apical aneurysms. Endocardial and epicardial substrate mapping revealed low voltage (<1.5 mV) scar in both endocardial and epicardial LV in 2 and only in the epicardium in 1 patient. Inducible VT was abolished with a combination of endocardial and epicardial ablation in 2 patients, but was ineffective in the third patient who had intramural reentry that required transcoronary ethanol ablation of an obtuse marginal vessel for abolition. The fourth patient had focal nonsustained repetitive VT from right ventricular outflow tract (RVOT), consistent with idiopathic RVOT-VT, that was successfully ablated. During follow-ups of 3-9 months, all patients remained free from VT.CONCLUSION: Monomorphic VT in apical HCM can be due to endocardial, epicardial or intramural reentry in areas of apical scar. Epicardial ablation or transcoronary alcohol ablation is required in some cases.

KW - Adult

KW - Body Surface Potential Mapping

KW - Cardiomyopathy, Hypertrophic/diagnosis

KW - Catheter Ablation/methods

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Tachycardia, Ventricular/diagnosis

KW - Treatment Outcome

U2 - 10.1111/j.1540-8167.2010.01875.x

DO - 10.1111/j.1540-8167.2010.01875.x

M3 - SCORING: Journal article

C2 - 20807280

VL - 22

SP - 41

EP - 48

JO - J CARDIOVASC ELECTR

JF - J CARDIOVASC ELECTR

SN - 1045-3873

IS - 1

ER -