Structural insights into transcription complexes
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Structural insights into transcription complexes. / Berger, Imre; Blanco, Alexandre G; Boelens, Rolf; Cavarelli, Jean; Coll, Miquel; Folkers, Gert E; Nie, Yan; Pogenberg, Vivian; Schultz, Patrick; Wilmanns, Matthias; Moras, Dino; Poterszman, Arnaud.
in: J STRUCT BIOL, Jahrgang 175, Nr. 2, 08.2011, S. 135-46.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Structural insights into transcription complexes
AU - Berger, Imre
AU - Blanco, Alexandre G
AU - Boelens, Rolf
AU - Cavarelli, Jean
AU - Coll, Miquel
AU - Folkers, Gert E
AU - Nie, Yan
AU - Pogenberg, Vivian
AU - Schultz, Patrick
AU - Wilmanns, Matthias
AU - Moras, Dino
AU - Poterszman, Arnaud
N1 - Copyright © 2011 Elsevier Inc. All rights reserved.
PY - 2011/8
Y1 - 2011/8
N2 - Control of transcription allows the regulation of cell activity in response to external stimuli and research in the field has greatly benefited from efforts in structural biology. In this review, based on specific examples from the European SPINE2-COMPLEXES initiative, we illustrate the impact of structural proteomics on our understanding of the molecular basis of gene expression. While most atomic structures were obtained by X-ray crystallography, the impact of solution NMR and cryo-electron microscopy is far from being negligible. Here, we summarize some highlights and illustrate the importance of specific technologies on the structural biology of protein-protein or protein/DNA transcription complexes: structure/function analysis of components the eukaryotic basal and activated transcription machinery with focus on the TFIID and TFIIH multi-subunit complexes as well as transcription regulators such as members of the nuclear hormone receptor families. We also discuss molecular aspects of promoter recognition and epigenetic control of gene expression.
AB - Control of transcription allows the regulation of cell activity in response to external stimuli and research in the field has greatly benefited from efforts in structural biology. In this review, based on specific examples from the European SPINE2-COMPLEXES initiative, we illustrate the impact of structural proteomics on our understanding of the molecular basis of gene expression. While most atomic structures were obtained by X-ray crystallography, the impact of solution NMR and cryo-electron microscopy is far from being negligible. Here, we summarize some highlights and illustrate the importance of specific technologies on the structural biology of protein-protein or protein/DNA transcription complexes: structure/function analysis of components the eukaryotic basal and activated transcription machinery with focus on the TFIID and TFIIH multi-subunit complexes as well as transcription regulators such as members of the nuclear hormone receptor families. We also discuss molecular aspects of promoter recognition and epigenetic control of gene expression.
KW - Allosteric Regulation
KW - Animals
KW - Cryoelectron Microscopy
KW - Crystallography, X-Ray
KW - Epigenesis, Genetic
KW - Humans
KW - Magnetic Resonance Spectroscopy
KW - Multiprotein Complexes/chemistry
KW - Promoter Regions, Genetic
KW - Protein Conformation
KW - Receptors, Cytoplasmic and Nuclear/chemistry
KW - Transcription Factors/chemistry
KW - Transcription, Genetic
U2 - 10.1016/j.jsb.2011.04.015
DO - 10.1016/j.jsb.2011.04.015
M3 - SCORING: Review article
C2 - 21571073
VL - 175
SP - 135
EP - 146
JO - J STRUCT BIOL
JF - J STRUCT BIOL
SN - 1047-8477
IS - 2
ER -