Sex-Specific Relationship Between Parathyroid Hormone and Platelet Indices in Phenotypes of Heart Failure-Results From the MyoVasc Study
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Sex-Specific Relationship Between Parathyroid Hormone and Platelet Indices in Phenotypes of Heart Failure-Results From the MyoVasc Study. / Dahlen, Bianca; Müller, Felix; Tröbs, Sven-Oliver; Heidorn, Marc William; Schulz, Andreas; Arnold, Natalie; Hermanns, M Iris; Schwuchow-Thonke, Sören; Prochaska, Jürgen H; Gori, Tommaso; Ten Cate, Hugo; Lackner, Karl J; Münzel, Thomas; Wild, Philipp S; Panova-Noeva, Marina.
in: FRONT CARDIOVASC MED, Jahrgang 8, 682521, 2021.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Sex-Specific Relationship Between Parathyroid Hormone and Platelet Indices in Phenotypes of Heart Failure-Results From the MyoVasc Study
AU - Dahlen, Bianca
AU - Müller, Felix
AU - Tröbs, Sven-Oliver
AU - Heidorn, Marc William
AU - Schulz, Andreas
AU - Arnold, Natalie
AU - Hermanns, M Iris
AU - Schwuchow-Thonke, Sören
AU - Prochaska, Jürgen H
AU - Gori, Tommaso
AU - Ten Cate, Hugo
AU - Lackner, Karl J
AU - Münzel, Thomas
AU - Wild, Philipp S
AU - Panova-Noeva, Marina
N1 - Copyright © 2021 Dahlen, Müller, Tröbs, Heidorn, Schulz, Arnold, Hermanns, Schwuchow-Thonke, Prochaska, Gori, ten Cate, Lackner, Münzel, Wild and Panova-Noeva.
PY - 2021
Y1 - 2021
N2 - Background: Heart failure (HF) is a multifactorial syndrome with pathophysiological complexities still not fully understood. Higher mean platelet volume (MPV), a potential marker of platelet activation, and high concentrations of parathyroid hormone (PTH) have been implicated in the pathogenesis of HF. Aim: This study aims to investigate sex-specifically the association between PTH concentrations and platelet indices in phenotypes of HF. Methods and Results: PTH and platelet indices (MPV and platelet count) were available in 1,896 participants from the MyoVasc study in Mainz, Germany. Multivariable linear regression models, adjusted for age, sex, season, vitamin D status, cardiovascular risk factors, comorbidities, estimated glomerular filtration rate, and medication, were used to assess the associations between platelet indices and PTH. The results showed distinct sex-specific associations between PTH and platelet indices. A positive association between PTH and MPV was found in females with symptomatic HF with reduced ejection fraction (HFrEF) only [β = 0.60 (0.19; 1.00)]. Platelet count was inversely associated with PTH in male HFrEF individuals [β = -7.6 (-15; -0.30)] and in both males and females with HF with preserved ejection fraction (HFpEF). Conclusion: This study reports differential, sex-specific relationships between PTH and platelet indices in HF individuals independent of vitamin D status and clinical profile. Particularly in phenotypes of symptomatic HF, distinct associations were observed, suggesting a sex-specific mechanism involved in the interaction between PTH and platelets.
AB - Background: Heart failure (HF) is a multifactorial syndrome with pathophysiological complexities still not fully understood. Higher mean platelet volume (MPV), a potential marker of platelet activation, and high concentrations of parathyroid hormone (PTH) have been implicated in the pathogenesis of HF. Aim: This study aims to investigate sex-specifically the association between PTH concentrations and platelet indices in phenotypes of HF. Methods and Results: PTH and platelet indices (MPV and platelet count) were available in 1,896 participants from the MyoVasc study in Mainz, Germany. Multivariable linear regression models, adjusted for age, sex, season, vitamin D status, cardiovascular risk factors, comorbidities, estimated glomerular filtration rate, and medication, were used to assess the associations between platelet indices and PTH. The results showed distinct sex-specific associations between PTH and platelet indices. A positive association between PTH and MPV was found in females with symptomatic HF with reduced ejection fraction (HFrEF) only [β = 0.60 (0.19; 1.00)]. Platelet count was inversely associated with PTH in male HFrEF individuals [β = -7.6 (-15; -0.30)] and in both males and females with HF with preserved ejection fraction (HFpEF). Conclusion: This study reports differential, sex-specific relationships between PTH and platelet indices in HF individuals independent of vitamin D status and clinical profile. Particularly in phenotypes of symptomatic HF, distinct associations were observed, suggesting a sex-specific mechanism involved in the interaction between PTH and platelets.
U2 - 10.3389/fcvm.2021.682521
DO - 10.3389/fcvm.2021.682521
M3 - SCORING: Journal article
C2 - 34222377
VL - 8
JO - FRONT CARDIOVASC MED
JF - FRONT CARDIOVASC MED
SN - 2297-055X
M1 - 682521
ER -
