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Serum Neurofilament Light Chain Levels in the Intensive Care Unit: Comparison between Severely Ill Patients with and without Coronavirus Disease 2019.

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Serum Neurofilament Light Chain Levels in the Intensive Care Unit: Comparison between Severely Ill Patients with and without Coronavirus Disease 2019. / Sutter, R; Hert, L; De, Marchis GM; Twerenbold, R; Kappos, L; Naegelin, Y; Kuster, GM; Benkert, P; Jost, J; Maceski, AM; Rüegg, S; Siegemund, M; Leppert, D; Kuhle, J.

in: ANN NEUROL, Jahrgang 89, Nr. 3, 03.2021, S. 610-616.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Sutter, R, Hert, L, De, MGM, Twerenbold, R, Kappos, L, Naegelin, Y, Kuster, GM, Benkert, P, Jost, J, Maceski, AM, Rüegg, S, Siegemund, M, Leppert, D & Kuhle, J 2021, 'Serum Neurofilament Light Chain Levels in the Intensive Care Unit: Comparison between Severely Ill Patients with and without Coronavirus Disease 2019.', ANN NEUROL, Jg. 89, Nr. 3, S. 610-616. https://doi.org/10.1002/ana.26004

APA

Sutter, R., Hert, L., De, M. GM., Twerenbold, R., Kappos, L., Naegelin, Y., Kuster, GM., Benkert, P., Jost, J., Maceski, AM., Rüegg, S., Siegemund, M., Leppert, D., & Kuhle, J. (2021). Serum Neurofilament Light Chain Levels in the Intensive Care Unit: Comparison between Severely Ill Patients with and without Coronavirus Disease 2019. ANN NEUROL, 89(3), 610-616. https://doi.org/10.1002/ana.26004

Vancouver

Sutter R, Hert L, De MGM, Twerenbold R, Kappos L, Naegelin Y et al. Serum Neurofilament Light Chain Levels in the Intensive Care Unit: Comparison between Severely Ill Patients with and without Coronavirus Disease 2019. ANN NEUROL. 2021 Mär;89(3):610-616. https://doi.org/10.1002/ana.26004

Bibtex

@article{1210006a129b4fad8cf9b235fd6a15d9,
title = "Serum Neurofilament Light Chain Levels in the Intensive Care Unit: Comparison between Severely Ill Patients with and without Coronavirus Disease 2019.",
abstract = "There is emerging evidence for multifarious neurological manifestations of coronavirus disease 2019 (COVID-19), but little is known regarding whether they reflect structural damage to the nervous system. Serum neurofilament light chain (sNfL) is a specific biomarker of neuronal injury. We measured sNfL concentrations of 29 critically ill COVID-19 patients, 10 critically ill non-COVID-19 patients, and 259 healthy controls. After adjusting for neurological comorbidities and age, sNfL concentrations were higher in patients with COVID-19 versus both comparator groups. Higher sNfL levels were associated with unfavorable short-term outcome, indicating that neuronal injury is common and pronounced in critically ill patients. ANN NEUROL 2021;89:610-616.",
author = "R Sutter and L Hert and De, {Marchis GM} and R Twerenbold and L Kappos and Y Naegelin and GM Kuster and P Benkert and J Jost and AM Maceski and S R{\"u}egg and M Siegemund and D Leppert and J Kuhle",
year = "2021",
month = mar,
doi = "10.1002/ana.26004",
language = "English",
volume = "89",
pages = "610--616",
journal = "ANN NEUROL",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Serum Neurofilament Light Chain Levels in the Intensive Care Unit: Comparison between Severely Ill Patients with and without Coronavirus Disease 2019.

AU - Sutter, R

AU - Hert, L

AU - De, Marchis GM

AU - Twerenbold, R

AU - Kappos, L

AU - Naegelin, Y

AU - Kuster, GM

AU - Benkert, P

AU - Jost, J

AU - Maceski, AM

AU - Rüegg, S

AU - Siegemund, M

AU - Leppert, D

AU - Kuhle, J

PY - 2021/3

Y1 - 2021/3

N2 - There is emerging evidence for multifarious neurological manifestations of coronavirus disease 2019 (COVID-19), but little is known regarding whether they reflect structural damage to the nervous system. Serum neurofilament light chain (sNfL) is a specific biomarker of neuronal injury. We measured sNfL concentrations of 29 critically ill COVID-19 patients, 10 critically ill non-COVID-19 patients, and 259 healthy controls. After adjusting for neurological comorbidities and age, sNfL concentrations were higher in patients with COVID-19 versus both comparator groups. Higher sNfL levels were associated with unfavorable short-term outcome, indicating that neuronal injury is common and pronounced in critically ill patients. ANN NEUROL 2021;89:610-616.

AB - There is emerging evidence for multifarious neurological manifestations of coronavirus disease 2019 (COVID-19), but little is known regarding whether they reflect structural damage to the nervous system. Serum neurofilament light chain (sNfL) is a specific biomarker of neuronal injury. We measured sNfL concentrations of 29 critically ill COVID-19 patients, 10 critically ill non-COVID-19 patients, and 259 healthy controls. After adjusting for neurological comorbidities and age, sNfL concentrations were higher in patients with COVID-19 versus both comparator groups. Higher sNfL levels were associated with unfavorable short-term outcome, indicating that neuronal injury is common and pronounced in critically ill patients. ANN NEUROL 2021;89:610-616.

UR - http://europepmc.org/abstract/med/33377539

U2 - 10.1002/ana.26004

DO - 10.1002/ana.26004

M3 - SCORING: Journal article

C2 - 33377539

VL - 89

SP - 610

EP - 616

JO - ANN NEUROL

JF - ANN NEUROL

SN - 0364-5134

IS - 3

ER -