Sepsis-Pathophysiology and Therapeutic Concepts
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Sepsis-Pathophysiology and Therapeutic Concepts. / Jarczak, Dominik; Kluge, Stefan; Nierhaus, Axel.
in: FRONT MED-LAUSANNE, Jahrgang 8, 2021, S. 628302.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - Sepsis-Pathophysiology and Therapeutic Concepts
AU - Jarczak, Dominik
AU - Kluge, Stefan
AU - Nierhaus, Axel
N1 - Copyright © 2021 Jarczak, Kluge and Nierhaus.
PY - 2021
Y1 - 2021
N2 - Sepsis is a life-threatening condition and a global disease burden. Today, the heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated host response to infection, with renewed emphasis on immune pathophysiology. Despite all efforts of experimental and clinical research during the last three decades, the ability to positively influence course and outcome of the syndrome remains limited. Evidence-based therapy still consists of basic causal and supportive measures, while adjuvant interventions such as blood purification or targeted immunotherapy largely remain without proof of effectiveness so far. With this review, we aim to provide an overview of sepsis immune pathophysiology, to update the choice of therapeutic approaches targeting different immunological mechanisms in the course of sepsis and septic shock, and to call for a paradigm shift from the pathogen to the host response as a potentially more promising angle.
AB - Sepsis is a life-threatening condition and a global disease burden. Today, the heterogeneous syndrome is defined as severe organ dysfunction caused by a dysregulated host response to infection, with renewed emphasis on immune pathophysiology. Despite all efforts of experimental and clinical research during the last three decades, the ability to positively influence course and outcome of the syndrome remains limited. Evidence-based therapy still consists of basic causal and supportive measures, while adjuvant interventions such as blood purification or targeted immunotherapy largely remain without proof of effectiveness so far. With this review, we aim to provide an overview of sepsis immune pathophysiology, to update the choice of therapeutic approaches targeting different immunological mechanisms in the course of sepsis and septic shock, and to call for a paradigm shift from the pathogen to the host response as a potentially more promising angle.
U2 - 10.3389/fmed.2021.628302
DO - 10.3389/fmed.2021.628302
M3 - SCORING: Review article
C2 - 34055825
VL - 8
SP - 628302
JO - FRONT MED-LAUSANNE
JF - FRONT MED-LAUSANNE
SN - 2296-858X
ER -
