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Selective attenuation of norepinephrine release and stress-induced heart rate increase by partial adenosine A1 agonism.

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Selective attenuation of norepinephrine release and stress-induced heart rate increase by partial adenosine A1 agonism. / Bott-Flügel, Lorenz; Bernshausen, Alexandra; Schneider, Heike; Luppa, Peter; Zimmermann, Katja; Albrecht-Küpper, Barbara; Kast, Raimund; Laugwitz, Karl-Ludwig; Ehmke, Heimo; Knorr, Andreas; Seyfarth, Melchior.

in: PLOS ONE, Jahrgang 6, Nr. 3, 3, 2011, S. 18048.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Bott-Flügel, L, Bernshausen, A, Schneider, H, Luppa, P, Zimmermann, K, Albrecht-Küpper, B, Kast, R, Laugwitz, K-L, Ehmke, H, Knorr, A & Seyfarth, M 2011, 'Selective attenuation of norepinephrine release and stress-induced heart rate increase by partial adenosine A1 agonism.', PLOS ONE, Jg. 6, Nr. 3, 3, S. 18048. https://doi.org/10.1371/journal.pone.0018048

APA

Bott-Flügel, L., Bernshausen, A., Schneider, H., Luppa, P., Zimmermann, K., Albrecht-Küpper, B., Kast, R., Laugwitz, K-L., Ehmke, H., Knorr, A., & Seyfarth, M. (2011). Selective attenuation of norepinephrine release and stress-induced heart rate increase by partial adenosine A1 agonism. PLOS ONE, 6(3), 18048. [3]. https://doi.org/10.1371/journal.pone.0018048

Vancouver

Bott-Flügel L, Bernshausen A, Schneider H, Luppa P, Zimmermann K, Albrecht-Küpper B et al. Selective attenuation of norepinephrine release and stress-induced heart rate increase by partial adenosine A1 agonism. PLOS ONE. 2011;6(3):18048. 3. https://doi.org/10.1371/journal.pone.0018048

Bibtex

@article{5830d40ed81e4b489cb28e0fe97183f7,
title = "Selective attenuation of norepinephrine release and stress-induced heart rate increase by partial adenosine A1 agonism.",
abstract = "The release of the neurotransmitter norepinephrine (NE) is modulated by presynaptic adenosine receptors. In the present study we investigated the effect of a partial activation of this feedback mechanism. We hypothesized that partial agonism would have differential effects on NE release in isolated hearts as well as on heart rate in vivo depending on the genetic background and baseline sympathetic activity. In isolated perfused hearts of Wistar and Spontaneously Hypertensive Rats (SHR), NE release was induced by electrical stimulation under control conditions (S1), and with capadenoson 6 · 10(-8) M (30 µg/l), 6 · 10(-7) M (300 µg/l) or 2-chloro-N(6)-cyclopentyladenosine (CCPA) 10(-6) M (S2). Under control conditions (S1), NE release was significantly higher in SHR hearts compared to Wistar (766+/-87 pmol/g vs. 173+/-18 pmol/g, p",
keywords = "Animals, Female, Rats, Rats, Wistar, Stress, Physiological/*drug effects, Blood Pressure/drug effects, Adenosine A1 Receptor Agonists/*pharmacology, Heart Rate/*drug effects, Norepinephrine/*secretion, Rats, Inbred SHR, Receptor, Adenosine A1/*metabolism, Restraint, Physical, Animals, Female, Rats, Rats, Wistar, Stress, Physiological/*drug effects, Blood Pressure/drug effects, Adenosine A1 Receptor Agonists/*pharmacology, Heart Rate/*drug effects, Norepinephrine/*secretion, Rats, Inbred SHR, Receptor, Adenosine A1/*metabolism, Restraint, Physical",
author = "Lorenz Bott-Fl{\"u}gel and Alexandra Bernshausen and Heike Schneider and Peter Luppa and Katja Zimmermann and Barbara Albrecht-K{\"u}pper and Raimund Kast and Karl-Ludwig Laugwitz and Heimo Ehmke and Andreas Knorr and Melchior Seyfarth",
year = "2011",
doi = "10.1371/journal.pone.0018048",
language = "English",
volume = "6",
pages = "18048",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "3",

}

RIS

TY - JOUR

T1 - Selective attenuation of norepinephrine release and stress-induced heart rate increase by partial adenosine A1 agonism.

AU - Bott-Flügel, Lorenz

AU - Bernshausen, Alexandra

AU - Schneider, Heike

AU - Luppa, Peter

AU - Zimmermann, Katja

AU - Albrecht-Küpper, Barbara

AU - Kast, Raimund

AU - Laugwitz, Karl-Ludwig

AU - Ehmke, Heimo

AU - Knorr, Andreas

AU - Seyfarth, Melchior

PY - 2011

Y1 - 2011

N2 - The release of the neurotransmitter norepinephrine (NE) is modulated by presynaptic adenosine receptors. In the present study we investigated the effect of a partial activation of this feedback mechanism. We hypothesized that partial agonism would have differential effects on NE release in isolated hearts as well as on heart rate in vivo depending on the genetic background and baseline sympathetic activity. In isolated perfused hearts of Wistar and Spontaneously Hypertensive Rats (SHR), NE release was induced by electrical stimulation under control conditions (S1), and with capadenoson 6 · 10(-8) M (30 µg/l), 6 · 10(-7) M (300 µg/l) or 2-chloro-N(6)-cyclopentyladenosine (CCPA) 10(-6) M (S2). Under control conditions (S1), NE release was significantly higher in SHR hearts compared to Wistar (766+/-87 pmol/g vs. 173+/-18 pmol/g, p

AB - The release of the neurotransmitter norepinephrine (NE) is modulated by presynaptic adenosine receptors. In the present study we investigated the effect of a partial activation of this feedback mechanism. We hypothesized that partial agonism would have differential effects on NE release in isolated hearts as well as on heart rate in vivo depending on the genetic background and baseline sympathetic activity. In isolated perfused hearts of Wistar and Spontaneously Hypertensive Rats (SHR), NE release was induced by electrical stimulation under control conditions (S1), and with capadenoson 6 · 10(-8) M (30 µg/l), 6 · 10(-7) M (300 µg/l) or 2-chloro-N(6)-cyclopentyladenosine (CCPA) 10(-6) M (S2). Under control conditions (S1), NE release was significantly higher in SHR hearts compared to Wistar (766+/-87 pmol/g vs. 173+/-18 pmol/g, p

KW - Animals

KW - Female

KW - Rats

KW - Rats, Wistar

KW - Stress, Physiological/drug effects

KW - Blood Pressure/drug effects

KW - Adenosine A1 Receptor Agonists/pharmacology

KW - Heart Rate/drug effects

KW - Norepinephrine/secretion

KW - Rats, Inbred SHR

KW - Receptor, Adenosine A1/metabolism

KW - Restraint, Physical

KW - Animals

KW - Female

KW - Rats

KW - Rats, Wistar

KW - Stress, Physiological/drug effects

KW - Blood Pressure/drug effects

KW - Adenosine A1 Receptor Agonists/pharmacology

KW - Heart Rate/drug effects

KW - Norepinephrine/secretion

KW - Rats, Inbred SHR

KW - Receptor, Adenosine A1/metabolism

KW - Restraint, Physical

U2 - 10.1371/journal.pone.0018048

DO - 10.1371/journal.pone.0018048

M3 - SCORING: Journal article

VL - 6

SP - 18048

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 3

M1 - 3

ER -