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Restricted water diffusibility as measured by diffusion-weighted MR imaging and choline uptake in (11)C-choline PET/CT are correlated in pelvic lymph nodes in patients with prostate cancer

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Restricted water diffusibility as measured by diffusion-weighted MR imaging and choline uptake in (11)C-choline PET/CT are correlated in pelvic lymph nodes in patients with prostate cancer. / Beer, Ambros J; Eiber, Matthias; Souvatzoglou, Michael; Holzapfel, Konstantin; Ganter, Carl; Weirich, Gregor; Maurer, Tobias; Kübler, Hubert; Wester, Hans-Juergen; Gaa, Jochen; Krause, Bernd J.

in: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, Jahrgang 13, Nr. 2, 04.2011, S. 352-61.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung

Harvard

Beer, AJ, Eiber, M, Souvatzoglou, M, Holzapfel, K, Ganter, C, Weirich, G, Maurer, T, Kübler, H, Wester, H-J, Gaa, J & Krause, BJ 2011, 'Restricted water diffusibility as measured by diffusion-weighted MR imaging and choline uptake in (11)C-choline PET/CT are correlated in pelvic lymph nodes in patients with prostate cancer', Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, Jg. 13, Nr. 2, S. 352-61. https://doi.org/10.1007/s11307-010-0337-6

APA

Beer, A. J., Eiber, M., Souvatzoglou, M., Holzapfel, K., Ganter, C., Weirich, G., Maurer, T., Kübler, H., Wester, H-J., Gaa, J., & Krause, B. J. (2011). Restricted water diffusibility as measured by diffusion-weighted MR imaging and choline uptake in (11)C-choline PET/CT are correlated in pelvic lymph nodes in patients with prostate cancer. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging, 13(2), 352-61. https://doi.org/10.1007/s11307-010-0337-6

Vancouver

Beer AJ, Eiber M, Souvatzoglou M, Holzapfel K, Ganter C, Weirich G et al. Restricted water diffusibility as measured by diffusion-weighted MR imaging and choline uptake in (11)C-choline PET/CT are correlated in pelvic lymph nodes in patients with prostate cancer. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2011 Apr;13(2):352-61. https://doi.org/10.1007/s11307-010-0337-6

Bibtex

@article{2989d19bec784bfe874bdfd20f85432b,
title = "Restricted water diffusibility as measured by diffusion-weighted MR imaging and choline uptake in (11)C-choline PET/CT are correlated in pelvic lymph nodes in patients with prostate cancer",
abstract = "PURPOSE: (11)C-Choline-positron emission tomography (PET)/computed tomography (CT) is increasingly used in patients with prostate cancer. Another promising technique for assessment of tumor biology is diffusion-weighted MR imaging (DWI). The aim of the study was to compare the functional parameters standardized uptake value (SUV) in PET and apparent diffusion coefficient (ADC) value in DWI of lymph nodes in prostate cancer patients.PROCEDURES: Fourteen patients with prostate cancer underwent DWI at 1.5T and (11)C-Choline-PET/CT. ADC values and SUVs of all lymph nodes larger than 5 mm (n = 55) were compared by using linear regression analysis. Performance of DWI and (11)C-Choline PET was assessed by receiver operator characteristic curve analysis using histopathology or clinical follow-up as standard of reference.RESULTS: ADC values and SUV showed a moderate but highly significant inverse correlation (r = -0.5144, p < 0.0001). In lymph nodes with low ADC values, the dispersion of SUV was more pronounced. Moreover, a highly significant difference was observed for mean ADC values and SUV in lymph nodes considered as benign or malignant by follow-up/histopathology (ADC 1.60 ± 0.24 vs. 1.09 ± 0.23 × 10(-3) mm(2)/s; SUV 1.82 ± 0.57 vs. 4.68 ± 03.12; p < 0.0001, respectively).CONCLUSION: These pilot data propose the ADC value in DWI as a new potential imaging biomarker which might provide additional information on tumor pathophysiology compared to the SUV in (11)C-Choline PET/CT.",
keywords = "Aged, Carbon Radioisotopes, Choline, Diffusion Magnetic Resonance Imaging, Follow-Up Studies, Humans, Lymph Nodes, Lymphatic Metastasis, Male, Middle Aged, Pelvis, Positron-Emission Tomography, Prostate-Specific Antigen, Prostatic Neoplasms, ROC Curve, Tomography, X-Ray Computed, Water, Journal Article",
author = "Beer, {Ambros J} and Matthias Eiber and Michael Souvatzoglou and Konstantin Holzapfel and Carl Ganter and Gregor Weirich and Tobias Maurer and Hubert K{\"u}bler and Hans-Juergen Wester and Jochen Gaa and Krause, {Bernd J}",
year = "2011",
month = apr,
doi = "10.1007/s11307-010-0337-6",
language = "English",
volume = "13",
pages = "352--61",
journal = "MOL IMAGING BIOL",
issn = "1536-1632",
publisher = "Springer New York",
number = "2",

}

RIS

TY - JOUR

T1 - Restricted water diffusibility as measured by diffusion-weighted MR imaging and choline uptake in (11)C-choline PET/CT are correlated in pelvic lymph nodes in patients with prostate cancer

AU - Beer, Ambros J

AU - Eiber, Matthias

AU - Souvatzoglou, Michael

AU - Holzapfel, Konstantin

AU - Ganter, Carl

AU - Weirich, Gregor

AU - Maurer, Tobias

AU - Kübler, Hubert

AU - Wester, Hans-Juergen

AU - Gaa, Jochen

AU - Krause, Bernd J

PY - 2011/4

Y1 - 2011/4

N2 - PURPOSE: (11)C-Choline-positron emission tomography (PET)/computed tomography (CT) is increasingly used in patients with prostate cancer. Another promising technique for assessment of tumor biology is diffusion-weighted MR imaging (DWI). The aim of the study was to compare the functional parameters standardized uptake value (SUV) in PET and apparent diffusion coefficient (ADC) value in DWI of lymph nodes in prostate cancer patients.PROCEDURES: Fourteen patients with prostate cancer underwent DWI at 1.5T and (11)C-Choline-PET/CT. ADC values and SUVs of all lymph nodes larger than 5 mm (n = 55) were compared by using linear regression analysis. Performance of DWI and (11)C-Choline PET was assessed by receiver operator characteristic curve analysis using histopathology or clinical follow-up as standard of reference.RESULTS: ADC values and SUV showed a moderate but highly significant inverse correlation (r = -0.5144, p < 0.0001). In lymph nodes with low ADC values, the dispersion of SUV was more pronounced. Moreover, a highly significant difference was observed for mean ADC values and SUV in lymph nodes considered as benign or malignant by follow-up/histopathology (ADC 1.60 ± 0.24 vs. 1.09 ± 0.23 × 10(-3) mm(2)/s; SUV 1.82 ± 0.57 vs. 4.68 ± 03.12; p < 0.0001, respectively).CONCLUSION: These pilot data propose the ADC value in DWI as a new potential imaging biomarker which might provide additional information on tumor pathophysiology compared to the SUV in (11)C-Choline PET/CT.

AB - PURPOSE: (11)C-Choline-positron emission tomography (PET)/computed tomography (CT) is increasingly used in patients with prostate cancer. Another promising technique for assessment of tumor biology is diffusion-weighted MR imaging (DWI). The aim of the study was to compare the functional parameters standardized uptake value (SUV) in PET and apparent diffusion coefficient (ADC) value in DWI of lymph nodes in prostate cancer patients.PROCEDURES: Fourteen patients with prostate cancer underwent DWI at 1.5T and (11)C-Choline-PET/CT. ADC values and SUVs of all lymph nodes larger than 5 mm (n = 55) were compared by using linear regression analysis. Performance of DWI and (11)C-Choline PET was assessed by receiver operator characteristic curve analysis using histopathology or clinical follow-up as standard of reference.RESULTS: ADC values and SUV showed a moderate but highly significant inverse correlation (r = -0.5144, p < 0.0001). In lymph nodes with low ADC values, the dispersion of SUV was more pronounced. Moreover, a highly significant difference was observed for mean ADC values and SUV in lymph nodes considered as benign or malignant by follow-up/histopathology (ADC 1.60 ± 0.24 vs. 1.09 ± 0.23 × 10(-3) mm(2)/s; SUV 1.82 ± 0.57 vs. 4.68 ± 03.12; p < 0.0001, respectively).CONCLUSION: These pilot data propose the ADC value in DWI as a new potential imaging biomarker which might provide additional information on tumor pathophysiology compared to the SUV in (11)C-Choline PET/CT.

KW - Aged

KW - Carbon Radioisotopes

KW - Choline

KW - Diffusion Magnetic Resonance Imaging

KW - Follow-Up Studies

KW - Humans

KW - Lymph Nodes

KW - Lymphatic Metastasis

KW - Male

KW - Middle Aged

KW - Pelvis

KW - Positron-Emission Tomography

KW - Prostate-Specific Antigen

KW - Prostatic Neoplasms

KW - ROC Curve

KW - Tomography, X-Ray Computed

KW - Water

KW - Journal Article

U2 - 10.1007/s11307-010-0337-6

DO - 10.1007/s11307-010-0337-6

M3 - SCORING: Journal article

C2 - 20490932

VL - 13

SP - 352

EP - 361

JO - MOL IMAGING BIOL

JF - MOL IMAGING BIOL

SN - 1536-1632

IS - 2

ER -