Perception of thermal pain and the thermal grill illusion is associated with polymorphisms in the serotonin transporter gene.

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Perception of thermal pain and the thermal grill illusion is associated with polymorphisms in the serotonin transporter gene. / Lindstedt, Fredrik; Lonsdorf, Tina; Schalling, Martin; Kosek, Eva; Ingvar, Martin.

in: PLOS ONE, Jahrgang 6, Nr. 3, 3, 2011, S. 17752.

Publikationen: SCORING: Beitrag in Fachzeitschrift/ZeitungSCORING: ZeitschriftenaufsatzForschungBegutachtung

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@article{b0ce3c94aa2e4b9e8821782659274494,
title = "Perception of thermal pain and the thermal grill illusion is associated with polymorphisms in the serotonin transporter gene.",
abstract = "The main aim of this study was to assess if the perception of thermal pain thresholds is associated with genetically inferred levels of expression of the 5-HT transporter (5-HTT). Additionally, the perception of the so-called thermal grill illusion (TGI) was assessed. Forty-four healthy individuals (27 females, 17 males) were selected a-priori based on their 5-HTTLPR/rs25531 ('tri-allelic 5-HTTLPR') genotype, with inferred high or low 5-HTT expression. Thresholds for heat- and cold-pain were determined along with the sensory and affective dimensions of the TGI.",
keywords = "Adult, Humans, Male, Female, Middle Aged, Questionnaires, Young Adult, Reproducibility of Results, Genotype, Alleles, European Continental Ancestry Group/genetics, Cold Temperature, *Polymorphism, Genetic, Pain Threshold, Serotonin Plasma Membrane Transport Proteins/*genetics, Illusions/*genetics, *Pain Perception, Skin Temperature/genetics, *Temperature, Adult, Humans, Male, Female, Middle Aged, Questionnaires, Young Adult, Reproducibility of Results, Genotype, Alleles, European Continental Ancestry Group/genetics, Cold Temperature, *Polymorphism, Genetic, Pain Threshold, Serotonin Plasma Membrane Transport Proteins/*genetics, Illusions/*genetics, *Pain Perception, Skin Temperature/genetics, *Temperature",
author = "Fredrik Lindstedt and Tina Lonsdorf and Martin Schalling and Eva Kosek and Martin Ingvar",
year = "2011",
doi = "10.1371/journal.pone.0017752",
language = "English",
volume = "6",
pages = "17752",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "3",

}

RIS

TY - JOUR

T1 - Perception of thermal pain and the thermal grill illusion is associated with polymorphisms in the serotonin transporter gene.

AU - Lindstedt, Fredrik

AU - Lonsdorf, Tina

AU - Schalling, Martin

AU - Kosek, Eva

AU - Ingvar, Martin

PY - 2011

Y1 - 2011

N2 - The main aim of this study was to assess if the perception of thermal pain thresholds is associated with genetically inferred levels of expression of the 5-HT transporter (5-HTT). Additionally, the perception of the so-called thermal grill illusion (TGI) was assessed. Forty-four healthy individuals (27 females, 17 males) were selected a-priori based on their 5-HTTLPR/rs25531 ('tri-allelic 5-HTTLPR') genotype, with inferred high or low 5-HTT expression. Thresholds for heat- and cold-pain were determined along with the sensory and affective dimensions of the TGI.

AB - The main aim of this study was to assess if the perception of thermal pain thresholds is associated with genetically inferred levels of expression of the 5-HT transporter (5-HTT). Additionally, the perception of the so-called thermal grill illusion (TGI) was assessed. Forty-four healthy individuals (27 females, 17 males) were selected a-priori based on their 5-HTTLPR/rs25531 ('tri-allelic 5-HTTLPR') genotype, with inferred high or low 5-HTT expression. Thresholds for heat- and cold-pain were determined along with the sensory and affective dimensions of the TGI.

KW - Adult

KW - Humans

KW - Male

KW - Female

KW - Middle Aged

KW - Questionnaires

KW - Young Adult

KW - Reproducibility of Results

KW - Genotype

KW - Alleles

KW - European Continental Ancestry Group/genetics

KW - Cold Temperature

KW - Polymorphism, Genetic

KW - Pain Threshold

KW - Serotonin Plasma Membrane Transport Proteins/genetics

KW - Illusions/genetics

KW - Pain Perception

KW - Skin Temperature/genetics

KW - Temperature

KW - Adult

KW - Humans

KW - Male

KW - Female

KW - Middle Aged

KW - Questionnaires

KW - Young Adult

KW - Reproducibility of Results

KW - Genotype

KW - Alleles

KW - European Continental Ancestry Group/genetics

KW - Cold Temperature

KW - Polymorphism, Genetic

KW - Pain Threshold

KW - Serotonin Plasma Membrane Transport Proteins/genetics

KW - Illusions/genetics

KW - Pain Perception

KW - Skin Temperature/genetics

KW - Temperature

U2 - 10.1371/journal.pone.0017752

DO - 10.1371/journal.pone.0017752

M3 - SCORING: Journal article

VL - 6

SP - 17752

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 3

M1 - 3

ER -