Perception of thermal pain and the thermal grill illusion is associated with polymorphisms in the serotonin transporter gene.
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Perception of thermal pain and the thermal grill illusion is associated with polymorphisms in the serotonin transporter gene. / Lindstedt, Fredrik; Lonsdorf, Tina; Schalling, Martin; Kosek, Eva; Ingvar, Martin.
in: PLOS ONE, Jahrgang 6, Nr. 3, 3, 2011, S. 17752.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Perception of thermal pain and the thermal grill illusion is associated with polymorphisms in the serotonin transporter gene.
AU - Lindstedt, Fredrik
AU - Lonsdorf, Tina
AU - Schalling, Martin
AU - Kosek, Eva
AU - Ingvar, Martin
PY - 2011
Y1 - 2011
N2 - The main aim of this study was to assess if the perception of thermal pain thresholds is associated with genetically inferred levels of expression of the 5-HT transporter (5-HTT). Additionally, the perception of the so-called thermal grill illusion (TGI) was assessed. Forty-four healthy individuals (27 females, 17 males) were selected a-priori based on their 5-HTTLPR/rs25531 ('tri-allelic 5-HTTLPR') genotype, with inferred high or low 5-HTT expression. Thresholds for heat- and cold-pain were determined along with the sensory and affective dimensions of the TGI.
AB - The main aim of this study was to assess if the perception of thermal pain thresholds is associated with genetically inferred levels of expression of the 5-HT transporter (5-HTT). Additionally, the perception of the so-called thermal grill illusion (TGI) was assessed. Forty-four healthy individuals (27 females, 17 males) were selected a-priori based on their 5-HTTLPR/rs25531 ('tri-allelic 5-HTTLPR') genotype, with inferred high or low 5-HTT expression. Thresholds for heat- and cold-pain were determined along with the sensory and affective dimensions of the TGI.
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Questionnaires
KW - Young Adult
KW - Reproducibility of Results
KW - Genotype
KW - Alleles
KW - European Continental Ancestry Group/genetics
KW - Cold Temperature
KW - Polymorphism, Genetic
KW - Pain Threshold
KW - Serotonin Plasma Membrane Transport Proteins/genetics
KW - Illusions/genetics
KW - Pain Perception
KW - Skin Temperature/genetics
KW - Temperature
KW - Adult
KW - Humans
KW - Male
KW - Female
KW - Middle Aged
KW - Questionnaires
KW - Young Adult
KW - Reproducibility of Results
KW - Genotype
KW - Alleles
KW - European Continental Ancestry Group/genetics
KW - Cold Temperature
KW - Polymorphism, Genetic
KW - Pain Threshold
KW - Serotonin Plasma Membrane Transport Proteins/genetics
KW - Illusions/genetics
KW - Pain Perception
KW - Skin Temperature/genetics
KW - Temperature
U2 - 10.1371/journal.pone.0017752
DO - 10.1371/journal.pone.0017752
M3 - SCORING: Journal article
VL - 6
SP - 17752
JO - PLOS ONE
JF - PLOS ONE
SN - 1932-6203
IS - 3
M1 - 3
ER -