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Neutrophil-derived cathelicidin protects from neointimal hyperplasia

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Neutrophil-derived cathelicidin protects from neointimal hyperplasia. / Soehnlein, Oliver; Wantha, Sarawuth; Simsekyilmaz, Sakine; Döring, Yvonne; Megens, Remco T A; Mause, Sebastian F; Drechsler, Maik; Smeets, Ralf; Weinandy, Stefan; Schreiber, Fabian; Gries, Thomas; Jockenhoevel, Stefan; Möller, Martin; Vijayan, Santosh; van Zandvoort, Marc A M J; Agerberth, Birgitta; Pham, Christine T; Gallo, Richard L; Hackeng, Tilman M; Liehn, Elisa A; Zernecke, Alma; Klee, Doris; Weber, Christian.

in: SCI TRANSL MED, Jahrgang 3, Nr. 103, 05.10.2011, S. 103ra98.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Soehnlein, O, Wantha, S, Simsekyilmaz, S, Döring, Y, Megens, RTA, Mause, SF, Drechsler, M, Smeets, R, Weinandy, S, Schreiber, F, Gries, T, Jockenhoevel, S, Möller, M, Vijayan, S, van Zandvoort, MAMJ, Agerberth, B, Pham, CT, Gallo, RL, Hackeng, TM, Liehn, EA, Zernecke, A, Klee, D & Weber, C 2011, 'Neutrophil-derived cathelicidin protects from neointimal hyperplasia', SCI TRANSL MED, Jg. 3, Nr. 103, S. 103ra98. https://doi.org/10.1126/scitranslmed.3002531

APA

Soehnlein, O., Wantha, S., Simsekyilmaz, S., Döring, Y., Megens, R. T. A., Mause, S. F., Drechsler, M., Smeets, R., Weinandy, S., Schreiber, F., Gries, T., Jockenhoevel, S., Möller, M., Vijayan, S., van Zandvoort, M. A. M. J., Agerberth, B., Pham, C. T., Gallo, R. L., Hackeng, T. M., ... Weber, C. (2011). Neutrophil-derived cathelicidin protects from neointimal hyperplasia. SCI TRANSL MED, 3(103), 103ra98. https://doi.org/10.1126/scitranslmed.3002531

Vancouver

Soehnlein O, Wantha S, Simsekyilmaz S, Döring Y, Megens RTA, Mause SF et al. Neutrophil-derived cathelicidin protects from neointimal hyperplasia. SCI TRANSL MED. 2011 Okt 5;3(103):103ra98. https://doi.org/10.1126/scitranslmed.3002531

Bibtex

@article{3d8cb09771fa4f4fb5dfb18e626a106a,
title = "Neutrophil-derived cathelicidin protects from neointimal hyperplasia",
abstract = "Percutaneous transluminal angioplasty with stent implantation is used to dilate arteries narrowed by atherosclerotic plaques and to revascularize coronary arteries occluded by atherothrombosis in myocardial infarction. Commonly applied drug-eluting stents release antiproliferative or anti-inflammatory agents to reduce the incidence of in-stent stenosis. However, these stents may still lead to in-stent stenosis; they also show increased rates of late stent thrombosis, an obstacle to optimal revascularization possibly related to endothelial recovery. Here, we examined the contribution of neutrophils and neutrophilic granule proteins to arterial healing after injury. We found that neutrophil-borne cathelicidin (mouse CRAMP, human LL-37) promoted reendothelization and thereby limited neointima formation after stent implantation. We then translated these findings to an animal model using a neutrophil-instructing, biofunctionalized, miniaturized Nitinol stent coated with LL-37. This stent reduced in-stent stenosis in a mouse model of atherosclerosis, suggesting that LL-37 may promote vascular healing after interventional therapy.",
keywords = "Animals, Antimicrobial Cationic Peptides, Apolipoproteins E, Atherosclerosis, Cells, Cultured, Drug-Eluting Stents, Hyperplasia, Mice, Mice, Knockout, Neointima, Neutrophils",
author = "Oliver Soehnlein and Sarawuth Wantha and Sakine Simsekyilmaz and Yvonne D{\"o}ring and Megens, {Remco T A} and Mause, {Sebastian F} and Maik Drechsler and Ralf Smeets and Stefan Weinandy and Fabian Schreiber and Thomas Gries and Stefan Jockenhoevel and Martin M{\"o}ller and Santosh Vijayan and {van Zandvoort}, {Marc A M J} and Birgitta Agerberth and Pham, {Christine T} and Gallo, {Richard L} and Hackeng, {Tilman M} and Liehn, {Elisa A} and Alma Zernecke and Doris Klee and Christian Weber",
year = "2011",
month = oct,
day = "5",
doi = "10.1126/scitranslmed.3002531",
language = "English",
volume = "3",
pages = "103ra98",
journal = "SCI TRANSL MED",
issn = "1946-6234",
publisher = "AMER ASSOC ADVANCEMENT SCIENCE",
number = "103",

}

RIS

TY - JOUR

T1 - Neutrophil-derived cathelicidin protects from neointimal hyperplasia

AU - Soehnlein, Oliver

AU - Wantha, Sarawuth

AU - Simsekyilmaz, Sakine

AU - Döring, Yvonne

AU - Megens, Remco T A

AU - Mause, Sebastian F

AU - Drechsler, Maik

AU - Smeets, Ralf

AU - Weinandy, Stefan

AU - Schreiber, Fabian

AU - Gries, Thomas

AU - Jockenhoevel, Stefan

AU - Möller, Martin

AU - Vijayan, Santosh

AU - van Zandvoort, Marc A M J

AU - Agerberth, Birgitta

AU - Pham, Christine T

AU - Gallo, Richard L

AU - Hackeng, Tilman M

AU - Liehn, Elisa A

AU - Zernecke, Alma

AU - Klee, Doris

AU - Weber, Christian

PY - 2011/10/5

Y1 - 2011/10/5

N2 - Percutaneous transluminal angioplasty with stent implantation is used to dilate arteries narrowed by atherosclerotic plaques and to revascularize coronary arteries occluded by atherothrombosis in myocardial infarction. Commonly applied drug-eluting stents release antiproliferative or anti-inflammatory agents to reduce the incidence of in-stent stenosis. However, these stents may still lead to in-stent stenosis; they also show increased rates of late stent thrombosis, an obstacle to optimal revascularization possibly related to endothelial recovery. Here, we examined the contribution of neutrophils and neutrophilic granule proteins to arterial healing after injury. We found that neutrophil-borne cathelicidin (mouse CRAMP, human LL-37) promoted reendothelization and thereby limited neointima formation after stent implantation. We then translated these findings to an animal model using a neutrophil-instructing, biofunctionalized, miniaturized Nitinol stent coated with LL-37. This stent reduced in-stent stenosis in a mouse model of atherosclerosis, suggesting that LL-37 may promote vascular healing after interventional therapy.

AB - Percutaneous transluminal angioplasty with stent implantation is used to dilate arteries narrowed by atherosclerotic plaques and to revascularize coronary arteries occluded by atherothrombosis in myocardial infarction. Commonly applied drug-eluting stents release antiproliferative or anti-inflammatory agents to reduce the incidence of in-stent stenosis. However, these stents may still lead to in-stent stenosis; they also show increased rates of late stent thrombosis, an obstacle to optimal revascularization possibly related to endothelial recovery. Here, we examined the contribution of neutrophils and neutrophilic granule proteins to arterial healing after injury. We found that neutrophil-borne cathelicidin (mouse CRAMP, human LL-37) promoted reendothelization and thereby limited neointima formation after stent implantation. We then translated these findings to an animal model using a neutrophil-instructing, biofunctionalized, miniaturized Nitinol stent coated with LL-37. This stent reduced in-stent stenosis in a mouse model of atherosclerosis, suggesting that LL-37 may promote vascular healing after interventional therapy.

KW - Animals

KW - Antimicrobial Cationic Peptides

KW - Apolipoproteins E

KW - Atherosclerosis

KW - Cells, Cultured

KW - Drug-Eluting Stents

KW - Hyperplasia

KW - Mice

KW - Mice, Knockout

KW - Neointima

KW - Neutrophils

U2 - 10.1126/scitranslmed.3002531

DO - 10.1126/scitranslmed.3002531

M3 - SCORING: Journal article

C2 - 21974936

VL - 3

SP - 103ra98

JO - SCI TRANSL MED

JF - SCI TRANSL MED

SN - 1946-6234

IS - 103

ER -