More than just tumor destruction: immunomodulation by thermal ablation of cancer
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More than just tumor destruction: immunomodulation by thermal ablation of cancer. / Haen, Sebastian P; Pereira, Philippe L; Salih, Helmut R; Rammensee, Hans-Georg; Gouttefangeas, Cécile.
in: Clin Dev Immunol, Jahrgang 2011, 2011, S. 160250.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Review › Forschung
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TY - JOUR
T1 - More than just tumor destruction: immunomodulation by thermal ablation of cancer
AU - Haen, Sebastian P
AU - Pereira, Philippe L
AU - Salih, Helmut R
AU - Rammensee, Hans-Georg
AU - Gouttefangeas, Cécile
PY - 2011
Y1 - 2011
N2 - Over the past decades, thermoablative techniques for the therapy of localized tumors have gained importance in the treatment of patients not eligible for surgical resection. Anecdotal reports have described spontaneous distant tumor regression after thermal ablation, indicating a possible involvement of the immune system, hence an induction of antitumor immunity after thermoinduced therapy. In recent years, a growing body of evidence for modulation of both adaptive and innate immunity, as well as for the induction of danger signals through thermoablation, has emerged. Induced immune responses, however, are mostly weak and not sufficient for the complete eradication of established tumors or durable prevention of disease progression, and combination therapies with immunomodulating drugs are being evaluated with promising results. This article aims to summarize published findings on immune modulation through radiofrequency ablation, cryoablation, microwave ablation therapy, high-intensity focused ultrasound, and laser-induced thermotherapy.
AB - Over the past decades, thermoablative techniques for the therapy of localized tumors have gained importance in the treatment of patients not eligible for surgical resection. Anecdotal reports have described spontaneous distant tumor regression after thermal ablation, indicating a possible involvement of the immune system, hence an induction of antitumor immunity after thermoinduced therapy. In recent years, a growing body of evidence for modulation of both adaptive and innate immunity, as well as for the induction of danger signals through thermoablation, has emerged. Induced immune responses, however, are mostly weak and not sufficient for the complete eradication of established tumors or durable prevention of disease progression, and combination therapies with immunomodulating drugs are being evaluated with promising results. This article aims to summarize published findings on immune modulation through radiofrequency ablation, cryoablation, microwave ablation therapy, high-intensity focused ultrasound, and laser-induced thermotherapy.
KW - Ablation Techniques/methods
KW - Catheter Ablation
KW - Combined Modality Therapy
KW - Cryosurgery
KW - High-Intensity Focused Ultrasound Ablation
KW - Humans
KW - Hyperthermia, Induced/methods
KW - Immunomodulation
KW - Neoplasms/immunology
U2 - 10.1155/2011/160250
DO - 10.1155/2011/160250
M3 - SCORING: Review article
C2 - 22242035
VL - 2011
SP - 160250
ER -
