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Liver-primed memory T cells generated under noninflammatory conditions provide anti-infectious immunity

Standard

Liver-primed memory T cells generated under noninflammatory conditions provide anti-infectious immunity. / Böttcher, Jan P; Schanz, Oliver; Wohlleber, Dirk; Abdullah, Zeinab; Debey-Pascher, Svenja; Staratschek-Jox, Andrea; Höchst, Bastian; Hegenbarth, Silke; Grell, Jessica; Limmer, Andreas; Atreya, Imke; Neurath, Markus F; Busch, Dirk H; Schmitt, Edgar; van Endert, Peter; Kolanus, Waldemar; Kurts, Christian; Schultze, Joachim L; Diehl, Linda; Knolle, Percy A.

in: CELL REP, Jahrgang 3, Nr. 3, 28.03.2013, S. 779-95.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Böttcher, JP, Schanz, O, Wohlleber, D, Abdullah, Z, Debey-Pascher, S, Staratschek-Jox, A, Höchst, B, Hegenbarth, S, Grell, J, Limmer, A, Atreya, I, Neurath, MF, Busch, DH, Schmitt, E, van Endert, P, Kolanus, W, Kurts, C, Schultze, JL, Diehl, L & Knolle, PA 2013, 'Liver-primed memory T cells generated under noninflammatory conditions provide anti-infectious immunity', CELL REP, Jg. 3, Nr. 3, S. 779-95. https://doi.org/10.1016/j.celrep.2013.02.008

APA

Böttcher, J. P., Schanz, O., Wohlleber, D., Abdullah, Z., Debey-Pascher, S., Staratschek-Jox, A., Höchst, B., Hegenbarth, S., Grell, J., Limmer, A., Atreya, I., Neurath, M. F., Busch, D. H., Schmitt, E., van Endert, P., Kolanus, W., Kurts, C., Schultze, J. L., Diehl, L., & Knolle, P. A. (2013). Liver-primed memory T cells generated under noninflammatory conditions provide anti-infectious immunity. CELL REP, 3(3), 779-95. https://doi.org/10.1016/j.celrep.2013.02.008

Vancouver

Böttcher JP, Schanz O, Wohlleber D, Abdullah Z, Debey-Pascher S, Staratschek-Jox A et al. Liver-primed memory T cells generated under noninflammatory conditions provide anti-infectious immunity. CELL REP. 2013 Mär 28;3(3):779-95. https://doi.org/10.1016/j.celrep.2013.02.008

Bibtex

@article{fc51f4d198174eaba837f1b531fc5635,
title = "Liver-primed memory T cells generated under noninflammatory conditions provide anti-infectious immunity",
abstract = "Development of CD8(+) T cell (CTL) immunity or tolerance is linked to the conditions during T cell priming. Dendritic cells (DCs) matured during inflammation generate effector/memory T cells, whereas immature DCs cause T cell deletion/anergy. We identify a third outcome of T cell priming in absence of inflammation enabled by cross-presenting liver sinusoidal endothelial cells. Such priming generated memory T cells that were spared from deletion by immature DCs. Similar to central memory T cells, liver-primed T cells differentiated into effector CTLs upon antigen re-encounter on matured DCs even after prolonged absence of antigen. Their reactivation required combinatorial signaling through the TCR, CD28, and IL-12R and controlled bacterial and viral infections. Gene expression profiling identified liver-primed T cells as a distinct Neuropilin-1(+) memory population. Generation of liver-primed memory T cells may prevent pathogens that avoid DC maturation by innate immune escape from also escaping adaptive immunity through attrition of the T cell repertoire.",
keywords = "Animals, Antigens, CD28, CD8-Positive T-Lymphocytes, Cross-Priming, Dendritic Cells, Endothelial Cells, Gene Expression Profiling, Immunity, Innate, Immunologic Memory, Listeria monocytogenes, Liver, Lymphocyte Activation, Mice, Mice, Inbred C57BL, Neuropilin-1, Receptors, Antigen, T-Cell, Receptors, Interleukin-12",
author = "B{\"o}ttcher, {Jan P} and Oliver Schanz and Dirk Wohlleber and Zeinab Abdullah and Svenja Debey-Pascher and Andrea Staratschek-Jox and Bastian H{\"o}chst and Silke Hegenbarth and Jessica Grell and Andreas Limmer and Imke Atreya and Neurath, {Markus F} and Busch, {Dirk H} and Edgar Schmitt and {van Endert}, Peter and Waldemar Kolanus and Christian Kurts and Schultze, {Joachim L} and Linda Diehl and Knolle, {Percy A}",
note = "Copyright {\textcopyright} 2013 The Authors. Published by Elsevier Inc. All rights reserved.",
year = "2013",
month = mar,
day = "28",
doi = "10.1016/j.celrep.2013.02.008",
language = "English",
volume = "3",
pages = "779--95",
journal = "CELL REP",
issn = "2211-1247",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Liver-primed memory T cells generated under noninflammatory conditions provide anti-infectious immunity

AU - Böttcher, Jan P

AU - Schanz, Oliver

AU - Wohlleber, Dirk

AU - Abdullah, Zeinab

AU - Debey-Pascher, Svenja

AU - Staratschek-Jox, Andrea

AU - Höchst, Bastian

AU - Hegenbarth, Silke

AU - Grell, Jessica

AU - Limmer, Andreas

AU - Atreya, Imke

AU - Neurath, Markus F

AU - Busch, Dirk H

AU - Schmitt, Edgar

AU - van Endert, Peter

AU - Kolanus, Waldemar

AU - Kurts, Christian

AU - Schultze, Joachim L

AU - Diehl, Linda

AU - Knolle, Percy A

N1 - Copyright © 2013 The Authors. Published by Elsevier Inc. All rights reserved.

PY - 2013/3/28

Y1 - 2013/3/28

N2 - Development of CD8(+) T cell (CTL) immunity or tolerance is linked to the conditions during T cell priming. Dendritic cells (DCs) matured during inflammation generate effector/memory T cells, whereas immature DCs cause T cell deletion/anergy. We identify a third outcome of T cell priming in absence of inflammation enabled by cross-presenting liver sinusoidal endothelial cells. Such priming generated memory T cells that were spared from deletion by immature DCs. Similar to central memory T cells, liver-primed T cells differentiated into effector CTLs upon antigen re-encounter on matured DCs even after prolonged absence of antigen. Their reactivation required combinatorial signaling through the TCR, CD28, and IL-12R and controlled bacterial and viral infections. Gene expression profiling identified liver-primed T cells as a distinct Neuropilin-1(+) memory population. Generation of liver-primed memory T cells may prevent pathogens that avoid DC maturation by innate immune escape from also escaping adaptive immunity through attrition of the T cell repertoire.

AB - Development of CD8(+) T cell (CTL) immunity or tolerance is linked to the conditions during T cell priming. Dendritic cells (DCs) matured during inflammation generate effector/memory T cells, whereas immature DCs cause T cell deletion/anergy. We identify a third outcome of T cell priming in absence of inflammation enabled by cross-presenting liver sinusoidal endothelial cells. Such priming generated memory T cells that were spared from deletion by immature DCs. Similar to central memory T cells, liver-primed T cells differentiated into effector CTLs upon antigen re-encounter on matured DCs even after prolonged absence of antigen. Their reactivation required combinatorial signaling through the TCR, CD28, and IL-12R and controlled bacterial and viral infections. Gene expression profiling identified liver-primed T cells as a distinct Neuropilin-1(+) memory population. Generation of liver-primed memory T cells may prevent pathogens that avoid DC maturation by innate immune escape from also escaping adaptive immunity through attrition of the T cell repertoire.

KW - Animals

KW - Antigens, CD28

KW - CD8-Positive T-Lymphocytes

KW - Cross-Priming

KW - Dendritic Cells

KW - Endothelial Cells

KW - Gene Expression Profiling

KW - Immunity, Innate

KW - Immunologic Memory

KW - Listeria monocytogenes

KW - Liver

KW - Lymphocyte Activation

KW - Mice

KW - Mice, Inbred C57BL

KW - Neuropilin-1

KW - Receptors, Antigen, T-Cell

KW - Receptors, Interleukin-12

U2 - 10.1016/j.celrep.2013.02.008

DO - 10.1016/j.celrep.2013.02.008

M3 - SCORING: Journal article

C2 - 23499443

VL - 3

SP - 779

EP - 795

JO - CELL REP

JF - CELL REP

SN - 2211-1247

IS - 3

ER -