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Labile or stable: opposing consequences for memory when reactivated during waking and sleep.

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Labile or stable: opposing consequences for memory when reactivated during waking and sleep. / Diekelmann, Susanne; Büchel, Christian; Born, Jan; Rasch, Björn.

in: NAT NEUROSCI, Jahrgang 14, Nr. 3, 3, 2011, S. 381-386.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Diekelmann, S, Büchel, C, Born, J & Rasch, B 2011, 'Labile or stable: opposing consequences for memory when reactivated during waking and sleep.', NAT NEUROSCI, Jg. 14, Nr. 3, 3, S. 381-386. <http://www.ncbi.nlm.nih.gov/pubmed/21258327?dopt=Citation>

APA

Diekelmann, S., Büchel, C., Born, J., & Rasch, B. (2011). Labile or stable: opposing consequences for memory when reactivated during waking and sleep. NAT NEUROSCI, 14(3), 381-386. [3]. http://www.ncbi.nlm.nih.gov/pubmed/21258327?dopt=Citation

Vancouver

Diekelmann S, Büchel C, Born J, Rasch B. Labile or stable: opposing consequences for memory when reactivated during waking and sleep. NAT NEUROSCI. 2011;14(3):381-386. 3.

Bibtex

@article{90e3d60b1db04fa8973d098c23a9fb74,
title = "Labile or stable: opposing consequences for memory when reactivated during waking and sleep.",
abstract = "Memory consolidation is a dynamic process. Reconsolidation theory assumes that reactivation during wakefulness transiently destabilizes memories, requiring them to reconsolidate in order to persist. Memory reactivation also occurs during slow-wave sleep (SWS) and is assumed to underlie the consolidating effect of sleep. Here, we tested whether the same principle of transient destabilization applies to memory reactivation during SWS. We reactivated memories in humans by presenting associated odor cues either during SWS or wakefulness. Reactivation was followed by an interference task to probe memory stability. As we expected, reactivation during waking destabilized memories. In contrast, reactivation during SWS immediately stabilized memories, thereby directly increasing their resistance to interference. Functional magnetic resonance imaging revealed that reactivation during SWS mainly activated hippocampal and posterior cortical regions, whereas reactivation during wakefulness primarily activated prefrontal cortical areas. Our results show that reactivation of memory serves distinct functions depending on the brain state of wakefulness or sleep.",
keywords = "Humans, Magnetic Resonance Imaging, Cues, Memory/*physiology, Odors, Sleep/*physiology, Wakefulness/*physiology, Humans, Magnetic Resonance Imaging, Cues, Memory/*physiology, Odors, Sleep/*physiology, Wakefulness/*physiology",
author = "Susanne Diekelmann and Christian B{\"u}chel and Jan Born and Bj{\"o}rn Rasch",
year = "2011",
language = "English",
volume = "14",
pages = "381--386",
journal = "NAT NEUROSCI",
issn = "1097-6256",
publisher = "NATURE PUBLISHING GROUP",
number = "3",

}

RIS

TY - JOUR

T1 - Labile or stable: opposing consequences for memory when reactivated during waking and sleep.

AU - Diekelmann, Susanne

AU - Büchel, Christian

AU - Born, Jan

AU - Rasch, Björn

PY - 2011

Y1 - 2011

N2 - Memory consolidation is a dynamic process. Reconsolidation theory assumes that reactivation during wakefulness transiently destabilizes memories, requiring them to reconsolidate in order to persist. Memory reactivation also occurs during slow-wave sleep (SWS) and is assumed to underlie the consolidating effect of sleep. Here, we tested whether the same principle of transient destabilization applies to memory reactivation during SWS. We reactivated memories in humans by presenting associated odor cues either during SWS or wakefulness. Reactivation was followed by an interference task to probe memory stability. As we expected, reactivation during waking destabilized memories. In contrast, reactivation during SWS immediately stabilized memories, thereby directly increasing their resistance to interference. Functional magnetic resonance imaging revealed that reactivation during SWS mainly activated hippocampal and posterior cortical regions, whereas reactivation during wakefulness primarily activated prefrontal cortical areas. Our results show that reactivation of memory serves distinct functions depending on the brain state of wakefulness or sleep.

AB - Memory consolidation is a dynamic process. Reconsolidation theory assumes that reactivation during wakefulness transiently destabilizes memories, requiring them to reconsolidate in order to persist. Memory reactivation also occurs during slow-wave sleep (SWS) and is assumed to underlie the consolidating effect of sleep. Here, we tested whether the same principle of transient destabilization applies to memory reactivation during SWS. We reactivated memories in humans by presenting associated odor cues either during SWS or wakefulness. Reactivation was followed by an interference task to probe memory stability. As we expected, reactivation during waking destabilized memories. In contrast, reactivation during SWS immediately stabilized memories, thereby directly increasing their resistance to interference. Functional magnetic resonance imaging revealed that reactivation during SWS mainly activated hippocampal and posterior cortical regions, whereas reactivation during wakefulness primarily activated prefrontal cortical areas. Our results show that reactivation of memory serves distinct functions depending on the brain state of wakefulness or sleep.

KW - Humans

KW - Magnetic Resonance Imaging

KW - Cues

KW - Memory/physiology

KW - Odors

KW - Sleep/physiology

KW - Wakefulness/physiology

KW - Humans

KW - Magnetic Resonance Imaging

KW - Cues

KW - Memory/physiology

KW - Odors

KW - Sleep/physiology

KW - Wakefulness/physiology

M3 - SCORING: Journal article

VL - 14

SP - 381

EP - 386

JO - NAT NEUROSCI

JF - NAT NEUROSCI

SN - 1097-6256

IS - 3

M1 - 3

ER -