Ionizing radiation-induced DNA strand breaks and γ-H2AXγ-H2AX foci in cells exposed to nitric oxide
Abstract
A number of studies have demonstrated that nitric oxide enhances radiosensitivity of anoxic and hypoxic cells in vitro and in vivo, and some evidence points to a role for DNA damage and repair in this phenomenon. We have recently observed that nitric oxide enhances the formation of DNA single- and double-strand breaks following ionising irradiation, measured by the alkaline comet assay and immunofluorescence microscopy for γ-H2AXγ-H2AX.
Bibliografische Daten
Originalsprache | Englisch |
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ISSN | 1064-3745 |
DOIs | |
Status | Veröffentlicht - 2011 |
Extern publiziert | Ja |
PubMed | 21161626 |
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