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Intraventricular Thrombus Formation and Embolism in Takotsubo Syndrome: Insights From the International Takotsubo Registry

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Intraventricular Thrombus Formation and Embolism in Takotsubo Syndrome: Insights From the International Takotsubo Registry. / Ding, Katharina J; Cammann, Victoria L; Szawan, Konrad A; Stähli, Barbara E; Wischnewsky, Manfred; Di Vece, Davide; Citro, Rodolfo; Jaguszewski, Milosz; Seifert, Burkhardt; Sarcon, Annahita; Knorr, Maike; Heiner, Susanne; Gili, Sebastiano; D'Ascenzo, Fabrizio; Neuhaus, Michael; Napp, L Christian; Franke, Jennifer; Noutsias, Michel; Burgdorf, Christof; Koenig, Wolfgang; Kherad, Behrouz; Rajan, Lawrence; Michels, Guido; Pfister, Roman; Cuneo, Alessandro; Jacobshagen, Claudius; Karakas, Mahir; Pott, Alexander; Meyer, Philippe; Arroja, Jose D; Banning, Adrian; Cuculi, Florim; Kobza, Richard; Fischer, Thomas A; Vasankari, Tuija; Airaksinen, K E Juhani; Paolini, Carla; Bilato, Claudio; Carrilho-Ferreira, Pedro; Opolski, Grzegorz; Dworakowski, Rafal; MacCarthy, Philip; Kaiser, Christoph; Osswald, Stefan; Galiuto, Leonarda; Dichtl, Wolfgang; Chan, Christina; Bridgman, Paul; Delmas, Clément; Lairez, Olivier; El-Battrawy, Ibrahim; Akin, Ibrahim; Gilyarova, Ekaterina; Shilova, Alexandra; Gilyarov, Mikhail; Kozel, Martin; Tousek, Petr; Widimský, Petr; Winchester, David E; Galuszka, Jan; Ukena, Christian; Horowitz, John D; Di Mario, Carlo; Prasad, Abhiram; Rihal, Charanjit S; Pinto, Fausto J; Crea, Filippo; Borggrefe, Martin; Braun-Dullaeus, Ruediger C; Rottbauer, Wolfgang; Bauersachs, Johann; Katus, Hugo A; Hasenfuß, Gerd; Tschöpe, Carsten; Pieske, Burkert M; Thiele, Holger; Schunkert, Heribert; Böhm, Michael; Felix, Stephan B; Münzel, Thomas; Bax, Jeroen J; Lüscher, Thomas F; Ruschitzka, Frank; Ghadri, Jelena R; Bossone, Eduardo; Templin, Christian.

in: ARTERIOSCL THROM VAS, Jahrgang 40, Nr. 1, 01.01.2020, S. 279-287.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ding, KJ, Cammann, VL, Szawan, KA, Stähli, BE, Wischnewsky, M, Di Vece, D, Citro, R, Jaguszewski, M, Seifert, B, Sarcon, A, Knorr, M, Heiner, S, Gili, S, D'Ascenzo, F, Neuhaus, M, Napp, LC, Franke, J, Noutsias, M, Burgdorf, C, Koenig, W, Kherad, B, Rajan, L, Michels, G, Pfister, R, Cuneo, A, Jacobshagen, C, Karakas, M, Pott, A, Meyer, P, Arroja, JD, Banning, A, Cuculi, F, Kobza, R, Fischer, TA, Vasankari, T, Airaksinen, KEJ, Paolini, C, Bilato, C, Carrilho-Ferreira, P, Opolski, G, Dworakowski, R, MacCarthy, P, Kaiser, C, Osswald, S, Galiuto, L, Dichtl, W, Chan, C, Bridgman, P, Delmas, C, Lairez, O, El-Battrawy, I, Akin, I, Gilyarova, E, Shilova, A, Gilyarov, M, Kozel, M, Tousek, P, Widimský, P, Winchester, DE, Galuszka, J, Ukena, C, Horowitz, JD, Di Mario, C, Prasad, A, Rihal, CS, Pinto, FJ, Crea, F, Borggrefe, M, Braun-Dullaeus, RC, Rottbauer, W, Bauersachs, J, Katus, HA, Hasenfuß, G, Tschöpe, C, Pieske, BM, Thiele, H, Schunkert, H, Böhm, M, Felix, SB, Münzel, T, Bax, JJ, Lüscher, TF, Ruschitzka, F, Ghadri, JR, Bossone, E & Templin, C 2020, 'Intraventricular Thrombus Formation and Embolism in Takotsubo Syndrome: Insights From the International Takotsubo Registry', ARTERIOSCL THROM VAS, Jg. 40, Nr. 1, S. 279-287. https://doi.org/10.1161/ATVBAHA.119.313491

APA

Ding, K. J., Cammann, V. L., Szawan, K. A., Stähli, B. E., Wischnewsky, M., Di Vece, D., Citro, R., Jaguszewski, M., Seifert, B., Sarcon, A., Knorr, M., Heiner, S., Gili, S., D'Ascenzo, F., Neuhaus, M., Napp, L. C., Franke, J., Noutsias, M., Burgdorf, C., ... Templin, C. (2020). Intraventricular Thrombus Formation and Embolism in Takotsubo Syndrome: Insights From the International Takotsubo Registry. ARTERIOSCL THROM VAS, 40(1), 279-287. https://doi.org/10.1161/ATVBAHA.119.313491

Vancouver

Ding KJ, Cammann VL, Szawan KA, Stähli BE, Wischnewsky M, Di Vece D et al. Intraventricular Thrombus Formation and Embolism in Takotsubo Syndrome: Insights From the International Takotsubo Registry. ARTERIOSCL THROM VAS. 2020 Jan 1;40(1):279-287. https://doi.org/10.1161/ATVBAHA.119.313491

Bibtex

@article{380855917c624513b9583409a70ada3c,
title = "Intraventricular Thrombus Formation and Embolism in Takotsubo Syndrome: Insights From the International Takotsubo Registry",
abstract = "OBJECTIVE: Takotsubo syndrome (TTS) is characterized by acute left ventricular dysfunction, which can contribute to intraventricular thrombus and embolism. Still, prevalence and clinical impact of thrombus formation and embolic events on outcome of TTS patients remain unclear. This study aimed to investigate clinical features and outcomes of patients with and without intraventricular thrombus or embolism. Additionally, factors associated with thrombus formation or embolism, as well as predictors for mortality, were identified. Approach and Results: TTS patients enrolled in the International Takotsubo Registry at 28 centers in Australia, Europe, and the United States were dichotomized according to the occurrence/absence of intraventricular thrombus or embolism. Patients with intraventricular thrombus or embolism were defined as the ThrombEmb group. Of 1676 TTS patients, 56 (3.3%) patients developed intraventricular thrombus and/or embolism following TTS diagnosis (median time interval, 2.0 days [range, 0-38 days]). Patients in the ThrombEmb group had a different clinical profile including lower left ventricular ejection fraction, higher prevalence of the apical type, elevated levels of troponin and inflammatory markers, and higher prevalence of vascular disease. In a Firth bias-reduced penalized-likelihood logistic regression model apical type, left ventricular ejection fraction ≤30%, previous vascular disease, and a white blood cell count on admission >10×103 cells/μL emerged as independent predictors for thrombus formation or embolism.CONCLUSIONS: Intraventricular thrombus or embolism occur in 3.3% of patients in the acute phase of TTS. A simple risk score including clinical parameters associated with intraventricular thrombus formation or embolism identifies patients at increased risk.CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01947621.",
keywords = "Aged, Australia/epidemiology, Coronary Angiography, Electrocardiography, Embolism/diagnosis, Europe/epidemiology, Female, Follow-Up Studies, Heart Diseases/diagnosis, Heart Ventricles, Humans, Incidence, Magnetic Resonance Imaging, Cine, Male, Radionuclide Ventriculography, Registries, Risk Assessment/methods, Risk Factors, Survival Rate/trends, Takotsubo Cardiomyopathy/complications, Thrombosis/diagnosis, Time Factors, United States/epidemiology",
author = "Ding, {Katharina J} and Cammann, {Victoria L} and Szawan, {Konrad A} and St{\"a}hli, {Barbara E} and Manfred Wischnewsky and {Di Vece}, Davide and Rodolfo Citro and Milosz Jaguszewski and Burkhardt Seifert and Annahita Sarcon and Maike Knorr and Susanne Heiner and Sebastiano Gili and Fabrizio D'Ascenzo and Michael Neuhaus and Napp, {L Christian} and Jennifer Franke and Michel Noutsias and Christof Burgdorf and Wolfgang Koenig and Behrouz Kherad and Lawrence Rajan and Guido Michels and Roman Pfister and Alessandro Cuneo and Claudius Jacobshagen and Mahir Karakas and Alexander Pott and Philippe Meyer and Arroja, {Jose D} and Adrian Banning and Florim Cuculi and Richard Kobza and Fischer, {Thomas A} and Tuija Vasankari and Airaksinen, {K E Juhani} and Carla Paolini and Claudio Bilato and Pedro Carrilho-Ferreira and Grzegorz Opolski and Rafal Dworakowski and Philip MacCarthy and Christoph Kaiser and Stefan Osswald and Leonarda Galiuto and Wolfgang Dichtl and Christina Chan and Paul Bridgman and Cl{\'e}ment Delmas and Olivier Lairez and Ibrahim El-Battrawy and Ibrahim Akin and Ekaterina Gilyarova and Alexandra Shilova and Mikhail Gilyarov and Martin Kozel and Petr Tousek and Petr Widimsk{\'y} and Winchester, {David E} and Jan Galuszka and Christian Ukena and Horowitz, {John D} and {Di Mario}, Carlo and Abhiram Prasad and Rihal, {Charanjit S} and Pinto, {Fausto J} and Filippo Crea and Martin Borggrefe and Braun-Dullaeus, {Ruediger C} and Wolfgang Rottbauer and Johann Bauersachs and Katus, {Hugo A} and Gerd Hasenfu{\ss} and Carsten Tsch{\"o}pe and Pieske, {Burkert M} and Holger Thiele and Heribert Schunkert and Michael B{\"o}hm and Felix, {Stephan B} and Thomas M{\"u}nzel and Bax, {Jeroen J} and L{\"u}scher, {Thomas F} and Frank Ruschitzka and Ghadri, {Jelena R} and Eduardo Bossone and Christian Templin",
year = "2020",
month = jan,
day = "1",
doi = "10.1161/ATVBAHA.119.313491",
language = "English",
volume = "40",
pages = "279--287",
journal = "ARTERIOSCL THROM VAS",
issn = "1079-5642",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

RIS

TY - JOUR

T1 - Intraventricular Thrombus Formation and Embolism in Takotsubo Syndrome: Insights From the International Takotsubo Registry

AU - Ding, Katharina J

AU - Cammann, Victoria L

AU - Szawan, Konrad A

AU - Stähli, Barbara E

AU - Wischnewsky, Manfred

AU - Di Vece, Davide

AU - Citro, Rodolfo

AU - Jaguszewski, Milosz

AU - Seifert, Burkhardt

AU - Sarcon, Annahita

AU - Knorr, Maike

AU - Heiner, Susanne

AU - Gili, Sebastiano

AU - D'Ascenzo, Fabrizio

AU - Neuhaus, Michael

AU - Napp, L Christian

AU - Franke, Jennifer

AU - Noutsias, Michel

AU - Burgdorf, Christof

AU - Koenig, Wolfgang

AU - Kherad, Behrouz

AU - Rajan, Lawrence

AU - Michels, Guido

AU - Pfister, Roman

AU - Cuneo, Alessandro

AU - Jacobshagen, Claudius

AU - Karakas, Mahir

AU - Pott, Alexander

AU - Meyer, Philippe

AU - Arroja, Jose D

AU - Banning, Adrian

AU - Cuculi, Florim

AU - Kobza, Richard

AU - Fischer, Thomas A

AU - Vasankari, Tuija

AU - Airaksinen, K E Juhani

AU - Paolini, Carla

AU - Bilato, Claudio

AU - Carrilho-Ferreira, Pedro

AU - Opolski, Grzegorz

AU - Dworakowski, Rafal

AU - MacCarthy, Philip

AU - Kaiser, Christoph

AU - Osswald, Stefan

AU - Galiuto, Leonarda

AU - Dichtl, Wolfgang

AU - Chan, Christina

AU - Bridgman, Paul

AU - Delmas, Clément

AU - Lairez, Olivier

AU - El-Battrawy, Ibrahim

AU - Akin, Ibrahim

AU - Gilyarova, Ekaterina

AU - Shilova, Alexandra

AU - Gilyarov, Mikhail

AU - Kozel, Martin

AU - Tousek, Petr

AU - Widimský, Petr

AU - Winchester, David E

AU - Galuszka, Jan

AU - Ukena, Christian

AU - Horowitz, John D

AU - Di Mario, Carlo

AU - Prasad, Abhiram

AU - Rihal, Charanjit S

AU - Pinto, Fausto J

AU - Crea, Filippo

AU - Borggrefe, Martin

AU - Braun-Dullaeus, Ruediger C

AU - Rottbauer, Wolfgang

AU - Bauersachs, Johann

AU - Katus, Hugo A

AU - Hasenfuß, Gerd

AU - Tschöpe, Carsten

AU - Pieske, Burkert M

AU - Thiele, Holger

AU - Schunkert, Heribert

AU - Böhm, Michael

AU - Felix, Stephan B

AU - Münzel, Thomas

AU - Bax, Jeroen J

AU - Lüscher, Thomas F

AU - Ruschitzka, Frank

AU - Ghadri, Jelena R

AU - Bossone, Eduardo

AU - Templin, Christian

PY - 2020/1/1

Y1 - 2020/1/1

N2 - OBJECTIVE: Takotsubo syndrome (TTS) is characterized by acute left ventricular dysfunction, which can contribute to intraventricular thrombus and embolism. Still, prevalence and clinical impact of thrombus formation and embolic events on outcome of TTS patients remain unclear. This study aimed to investigate clinical features and outcomes of patients with and without intraventricular thrombus or embolism. Additionally, factors associated with thrombus formation or embolism, as well as predictors for mortality, were identified. Approach and Results: TTS patients enrolled in the International Takotsubo Registry at 28 centers in Australia, Europe, and the United States were dichotomized according to the occurrence/absence of intraventricular thrombus or embolism. Patients with intraventricular thrombus or embolism were defined as the ThrombEmb group. Of 1676 TTS patients, 56 (3.3%) patients developed intraventricular thrombus and/or embolism following TTS diagnosis (median time interval, 2.0 days [range, 0-38 days]). Patients in the ThrombEmb group had a different clinical profile including lower left ventricular ejection fraction, higher prevalence of the apical type, elevated levels of troponin and inflammatory markers, and higher prevalence of vascular disease. In a Firth bias-reduced penalized-likelihood logistic regression model apical type, left ventricular ejection fraction ≤30%, previous vascular disease, and a white blood cell count on admission >10×103 cells/μL emerged as independent predictors for thrombus formation or embolism.CONCLUSIONS: Intraventricular thrombus or embolism occur in 3.3% of patients in the acute phase of TTS. A simple risk score including clinical parameters associated with intraventricular thrombus formation or embolism identifies patients at increased risk.CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01947621.

AB - OBJECTIVE: Takotsubo syndrome (TTS) is characterized by acute left ventricular dysfunction, which can contribute to intraventricular thrombus and embolism. Still, prevalence and clinical impact of thrombus formation and embolic events on outcome of TTS patients remain unclear. This study aimed to investigate clinical features and outcomes of patients with and without intraventricular thrombus or embolism. Additionally, factors associated with thrombus formation or embolism, as well as predictors for mortality, were identified. Approach and Results: TTS patients enrolled in the International Takotsubo Registry at 28 centers in Australia, Europe, and the United States were dichotomized according to the occurrence/absence of intraventricular thrombus or embolism. Patients with intraventricular thrombus or embolism were defined as the ThrombEmb group. Of 1676 TTS patients, 56 (3.3%) patients developed intraventricular thrombus and/or embolism following TTS diagnosis (median time interval, 2.0 days [range, 0-38 days]). Patients in the ThrombEmb group had a different clinical profile including lower left ventricular ejection fraction, higher prevalence of the apical type, elevated levels of troponin and inflammatory markers, and higher prevalence of vascular disease. In a Firth bias-reduced penalized-likelihood logistic regression model apical type, left ventricular ejection fraction ≤30%, previous vascular disease, and a white blood cell count on admission >10×103 cells/μL emerged as independent predictors for thrombus formation or embolism.CONCLUSIONS: Intraventricular thrombus or embolism occur in 3.3% of patients in the acute phase of TTS. A simple risk score including clinical parameters associated with intraventricular thrombus formation or embolism identifies patients at increased risk.CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01947621.

KW - Aged

KW - Australia/epidemiology

KW - Coronary Angiography

KW - Electrocardiography

KW - Embolism/diagnosis

KW - Europe/epidemiology

KW - Female

KW - Follow-Up Studies

KW - Heart Diseases/diagnosis

KW - Heart Ventricles

KW - Humans

KW - Incidence

KW - Magnetic Resonance Imaging, Cine

KW - Male

KW - Radionuclide Ventriculography

KW - Registries

KW - Risk Assessment/methods

KW - Risk Factors

KW - Survival Rate/trends

KW - Takotsubo Cardiomyopathy/complications

KW - Thrombosis/diagnosis

KW - Time Factors

KW - United States/epidemiology

U2 - 10.1161/ATVBAHA.119.313491

DO - 10.1161/ATVBAHA.119.313491

M3 - SCORING: Journal article

C2 - 31766870

VL - 40

SP - 279

EP - 287

JO - ARTERIOSCL THROM VAS

JF - ARTERIOSCL THROM VAS

SN - 1079-5642

IS - 1

ER -