Inhibitor of apoptosis proteins as novel targets in inflammatory processes.
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Inhibitor of apoptosis proteins as novel targets in inflammatory processes. / Mayer, Bettina A; Rehberg, Markus; Erhardt, Annette; Wolf, Alexander; Reichel, Christoph A; Kracht, Michael; Krombach, Fritz; Tiegs, Gisa; Zahler, Stefan; Vollmar, Angelika M; Fürst, Robert.
in: ARTERIOSCL THROM VAS, Jahrgang 31, Nr. 10, 10, 2011, S. 2240-2250.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Inhibitor of apoptosis proteins as novel targets in inflammatory processes.
AU - Mayer, Bettina A
AU - Rehberg, Markus
AU - Erhardt, Annette
AU - Wolf, Alexander
AU - Reichel, Christoph A
AU - Kracht, Michael
AU - Krombach, Fritz
AU - Tiegs, Gisa
AU - Zahler, Stefan
AU - Vollmar, Angelika M
AU - Fürst, Robert
PY - 2011
Y1 - 2011
N2 - Inhibitor of apoptosis proteins (IAPs), such as X-linked or cellular IAP 1/2 (XIAP, cIAP1/2), are important regulators of apoptosis. IAP antagonists are currently under clinical investigation as anticancer agents. Interestingly, IAPs participate in the inflammation-associated TNF receptor signaling complex and regulate NF?B signaling. This raises the question about the role of IAPs in inflammation. Here, we investigated the anti-inflammatory potential of IAP inhibitors and the role of IAPs in inflammatory processes of endothelial cells.
AB - Inhibitor of apoptosis proteins (IAPs), such as X-linked or cellular IAP 1/2 (XIAP, cIAP1/2), are important regulators of apoptosis. IAP antagonists are currently under clinical investigation as anticancer agents. Interestingly, IAPs participate in the inflammation-associated TNF receptor signaling complex and regulate NF?B signaling. This raises the question about the role of IAPs in inflammation. Here, we investigated the anti-inflammatory potential of IAP inhibitors and the role of IAPs in inflammatory processes of endothelial cells.
KW - Animals
KW - Humans
KW - Male
KW - Time Factors
KW - Disease Models, Animal
KW - Mice
KW - Mice, Inbred C57BL
KW - Protein Processing, Post-Translational
KW - Hela Cells
KW - Enzyme Activation
KW - Transfection
KW - Dose-Response Relationship, Drug
KW - Apoptosis/drug effects
KW - Tumor Necrosis Factor-alpha/metabolism
KW - NF-kappa B/metabolism
KW - RNA Interference
KW - Ubiquitination
KW - Anti-Inflammatory Agents/pharmacology
KW - Arthritis, Experimental/immunology/metabolism/prevention & control
KW - Caspases/metabolism
KW - Cell Adhesion/drug effects
KW - Concanavalin A
KW - Drug-Induced Liver Injury/immunology/metabolism/prevention & control
KW - Endothelial Cells/drug effects/immunology/metabolism
KW - Inhibitor of Apoptosis Proteins/antagonists & inhibitors/genetics/metabolism
KW - Intercellular Adhesion Molecule-1/metabolism
KW - JNK Mitogen-Activated Protein Kinases/metabolism
KW - Leukocytes/drug effects/immunology/metabolism
KW - MAP Kinase Kinase Kinases/metabolism
KW - Proteasome Endopeptidase Complex/metabolism
KW - Serum Albumin, Bovine
KW - TNF Receptor-Associated Factor 2/metabolism
KW - TNF Receptor-Associated Factor 5/metabolism
KW - Transendothelial and Transepithelial Migration/drug effects
KW - p38 Mitogen-Activated Protein Kinases/metabolism
KW - Animals
KW - Humans
KW - Male
KW - Time Factors
KW - Disease Models, Animal
KW - Mice
KW - Mice, Inbred C57BL
KW - Protein Processing, Post-Translational
KW - Hela Cells
KW - Enzyme Activation
KW - Transfection
KW - Dose-Response Relationship, Drug
KW - Apoptosis/drug effects
KW - Tumor Necrosis Factor-alpha/metabolism
KW - NF-kappa B/metabolism
KW - RNA Interference
KW - Ubiquitination
KW - Anti-Inflammatory Agents/pharmacology
KW - Arthritis, Experimental/immunology/metabolism/prevention & control
KW - Caspases/metabolism
KW - Cell Adhesion/drug effects
KW - Concanavalin A
KW - Drug-Induced Liver Injury/immunology/metabolism/prevention & control
KW - Endothelial Cells/drug effects/immunology/metabolism
KW - Inhibitor of Apoptosis Proteins/antagonists & inhibitors/genetics/metabolism
KW - Intercellular Adhesion Molecule-1/metabolism
KW - JNK Mitogen-Activated Protein Kinases/metabolism
KW - Leukocytes/drug effects/immunology/metabolism
KW - MAP Kinase Kinase Kinases/metabolism
KW - Proteasome Endopeptidase Complex/metabolism
KW - Serum Albumin, Bovine
KW - TNF Receptor-Associated Factor 2/metabolism
KW - TNF Receptor-Associated Factor 5/metabolism
KW - Transendothelial and Transepithelial Migration/drug effects
KW - p38 Mitogen-Activated Protein Kinases/metabolism
M3 - SCORING: Journal article
VL - 31
SP - 2240
EP - 2250
JO - ARTERIOSCL THROM VAS
JF - ARTERIOSCL THROM VAS
SN - 1079-5642
IS - 10
M1 - 10
ER -