Incidence of retinopathy of prematurity in Germany: evaluation of current screening criteria
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Incidence of retinopathy of prematurity in Germany: evaluation of current screening criteria. / Retina.net ROP Registry.
in: ARCH DIS CHILD-FETAL, Jahrgang 106, Nr. 2, 03.2021, S. 189-193.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Incidence of retinopathy of prematurity in Germany: evaluation of current screening criteria
AU - Larsen, Petra P
AU - Müller, Andreas
AU - Lagrèze, Wolf A
AU - Holz, Frank G
AU - Stahl, Andreas
AU - Krohne, Tim U
AU - Retina.net ROP Registry
N1 - © Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.
PY - 2021/3
Y1 - 2021/3
N2 - OBJECTIVE: To evaluate current screening criteria for retinopathy of prematurity (ROP) by investigating the incidence of ROP requiring treatment in infants with gestational age (GA) ≥30 weeks or postmenstrual age (PMA) <32 weeks in Germany.METHODS: Three patient databases were analysed, that is, the German Quality Assurance Procedure in Neonatology (years 2011-2017; n=52 461 infants screened for ROP, 1505 infants treated for ROP), the German Retina.net ROP Registry (years 2011-2018; n=281 treated infants) and the ROP screening programme of two German university hospitals (years 2012-2016; n=837 screened infants).RESULTS: In the analysed cohorts, infants with GA ≥30 weeks represented 33.1%-38.5% of the screening populations but only 1.40%-1.42% of the cases requiring ROP treatment. In a cohort of 281 infants treated for ROP, all 4 infants with GA ≥30 weeks had additional risk factors for ROP including prolonged oxygen supplementation and/or significant comorbidities. Five infants (1.8%) were treated at 32 weeks PMA and none at PMA <32 weeks.CONCLUSIONS: In the investigated cohorts, preterm infants with GA ≥30 weeks carried a very low or no risk for developing treatment-requiring ROP unless additional risk factors were present, and no treatment was performed earlier than 32 weeks PMA. These findings are of relevance for the ongoing re-evaluation of ROP screening criteria.
AB - OBJECTIVE: To evaluate current screening criteria for retinopathy of prematurity (ROP) by investigating the incidence of ROP requiring treatment in infants with gestational age (GA) ≥30 weeks or postmenstrual age (PMA) <32 weeks in Germany.METHODS: Three patient databases were analysed, that is, the German Quality Assurance Procedure in Neonatology (years 2011-2017; n=52 461 infants screened for ROP, 1505 infants treated for ROP), the German Retina.net ROP Registry (years 2011-2018; n=281 treated infants) and the ROP screening programme of two German university hospitals (years 2012-2016; n=837 screened infants).RESULTS: In the analysed cohorts, infants with GA ≥30 weeks represented 33.1%-38.5% of the screening populations but only 1.40%-1.42% of the cases requiring ROP treatment. In a cohort of 281 infants treated for ROP, all 4 infants with GA ≥30 weeks had additional risk factors for ROP including prolonged oxygen supplementation and/or significant comorbidities. Five infants (1.8%) were treated at 32 weeks PMA and none at PMA <32 weeks.CONCLUSIONS: In the investigated cohorts, preterm infants with GA ≥30 weeks carried a very low or no risk for developing treatment-requiring ROP unless additional risk factors were present, and no treatment was performed earlier than 32 weeks PMA. These findings are of relevance for the ongoing re-evaluation of ROP screening criteria.
KW - Birth Weight
KW - Comorbidity
KW - Female
KW - Germany/epidemiology
KW - Gestational Age
KW - Hospitals, University
KW - Humans
KW - Incidence
KW - Infant, Newborn
KW - Infant, Premature
KW - Male
KW - Neonatal Screening/methods
KW - Retinopathy of Prematurity/epidemiology
KW - Retrospective Studies
KW - Risk Factors
U2 - 10.1136/archdischild-2020-319767
DO - 10.1136/archdischild-2020-319767
M3 - SCORING: Journal article
C2 - 32989047
VL - 106
SP - 189
EP - 193
JO - ARCH DIS CHILD-FETAL
JF - ARCH DIS CHILD-FETAL
SN - 1359-2998
IS - 2
ER -