Geniculocortical input drives genetic distinctions between primary and higher-order visual areas
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Geniculocortical input drives genetic distinctions between primary and higher-order visual areas. / Chou, Shen-Ju; Babot, Zoila; Leingärtner, Axel; Studer, Michele; Nakagawa, Yasushi; O'Leary, Dennis D M.
in: SCIENCE, Jahrgang 340, Nr. 6137, 07.06.2013, S. 1239-42.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Geniculocortical input drives genetic distinctions between primary and higher-order visual areas
AU - Chou, Shen-Ju
AU - Babot, Zoila
AU - Leingärtner, Axel
AU - Studer, Michele
AU - Nakagawa, Yasushi
AU - O'Leary, Dennis D M
PY - 2013/6/7
Y1 - 2013/6/7
N2 - Studies of area patterning of the neocortex have focused on primary areas, concluding that the primary visual area, V1, is specified by transcription factors (TFs) expressed by progenitors. Mechanisms that determine higher-order visual areas (V(HO)) and distinguish them from V1 are unknown. We demonstrated a requirement for thalamocortical axon (TCA) input by genetically deleting geniculocortical TCAs and showed that they drive differentiation of patterned gene expression that distinguishes V1 and V(HO). Our findings suggest a multistage process for area patterning: TFs expressed by progenitors specify an occipital visual cortical field that differentiates into V1 and V(HO); this latter phase requires geniculocortical TCA input to the nascent V1 that determines genetic distinctions between V1 and V(HO) for all layers and ultimately determines their area-specific functional properties.
AB - Studies of area patterning of the neocortex have focused on primary areas, concluding that the primary visual area, V1, is specified by transcription factors (TFs) expressed by progenitors. Mechanisms that determine higher-order visual areas (V(HO)) and distinguish them from V1 are unknown. We demonstrated a requirement for thalamocortical axon (TCA) input by genetically deleting geniculocortical TCAs and showed that they drive differentiation of patterned gene expression that distinguishes V1 and V(HO). Our findings suggest a multistage process for area patterning: TFs expressed by progenitors specify an occipital visual cortical field that differentiates into V1 and V(HO); this latter phase requires geniculocortical TCA input to the nascent V1 that determines genetic distinctions between V1 and V(HO) for all layers and ultimately determines their area-specific functional properties.
KW - Animals
KW - Axons
KW - Gene Deletion
KW - Gene Expression Regulation
KW - Genetic Markers
KW - Mice
KW - Mice, Knockout
KW - Neocortex
KW - Neural Stem Cells
KW - Thalamus
KW - Transcription Factors
KW - Visual Cortex
KW - Visual Fields
U2 - 10.1126/science.1232806
DO - 10.1126/science.1232806
M3 - SCORING: Journal article
C2 - 23744949
VL - 340
SP - 1239
EP - 1242
JO - SCIENCE
JF - SCIENCE
SN - 0036-8075
IS - 6137
ER -