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Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers.

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Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers. / Beesley, Jonathan; Pickett, Hilda A; Johnatty, Sharon E; Dunning, Alison M; Chen, Xiaoqing; Li, Jun; Michailidou, Kyriaki; Lu, Yi; Rider, David N; Palmieri, Rachel T; Stutz, Michael D; Lambrechts, Diether; Despierre, Evelyn; Lambrechts, Sandrina; Vergote, Ignace; Chang-Claude, Jenny; Nickels, Stefan; Vrieling, Alina; Flesch-Janys, Dieter; Wang-Gohrke, Shan; Eilber, Ursula; Bogdanova, Natalia; Antonenkova, Natalia; Runnebaum, Ingo B; Dörk, Thilo; Goodman, Marc T; Lurie, Galina; Wilkens, Lynne R; Matsuno, Rayna K; Kiemeney, Lambertus A; Aben, Katja K H; Marees, Tamara; Massuger, Leon F A G; Fridley, Brooke L; Vierkant, Robert A; Bandera, Elisa V; Olson, Sara H; Orlow, Irene; Rodriguez-Rodriguez, Lorna; Cook, Linda S; Le, Nhu D; Brooks-Wilson, Angela; Kelemen, Linda E; Campbell, Ian; Gayther, Simon A; Ramus, Susan J; Gentry-Maharaj, Aleksandra; Menon, Usha; Ahmed, Shahana; Baynes, Caroline; Pharoah, Paul D; Group, Australian Ovarian Cancer Study; Investigators, ABCTB; Muir, Kenneth; Lophatananon, Artitaya; Chaiwerawattana, Arkom; Wiangnon, Surapon; Macgregor, Stuart; Easton, Douglas F; Reddel, Roger R; Goode, Ellen L; Chenevix-Trench, Georgia; Consortium, Ovarian Cancer Association.

in: PLOS ONE, Jahrgang 6, Nr. 9, 9, 2011, S. 24987.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Beesley, J, Pickett, HA, Johnatty, SE, Dunning, AM, Chen, X, Li, J, Michailidou, K, Lu, Y, Rider, DN, Palmieri, RT, Stutz, MD, Lambrechts, D, Despierre, E, Lambrechts, S, Vergote, I, Chang-Claude, J, Nickels, S, Vrieling, A, Flesch-Janys, D, Wang-Gohrke, S, Eilber, U, Bogdanova, N, Antonenkova, N, Runnebaum, IB, Dörk, T, Goodman, MT, Lurie, G, Wilkens, LR, Matsuno, RK, Kiemeney, LA, Aben, KKH, Marees, T, Massuger, LFAG, Fridley, BL, Vierkant, RA, Bandera, EV, Olson, SH, Orlow, I, Rodriguez-Rodriguez, L, Cook, LS, Le, ND, Brooks-Wilson, A, Kelemen, LE, Campbell, I, Gayther, SA, Ramus, SJ, Gentry-Maharaj, A, Menon, U, Ahmed, S, Baynes, C, Pharoah, PD, Group, AOCS, Investigators, ABCTB, Muir, K, Lophatananon, A, Chaiwerawattana, A, Wiangnon, S, Macgregor, S, Easton, DF, Reddel, RR, Goode, EL, Chenevix-Trench, G & Consortium, OCA 2011, 'Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers.', PLOS ONE, Jg. 6, Nr. 9, 9, S. 24987. <http://www.ncbi.nlm.nih.gov/pubmed/21949822?dopt=Citation>

APA

Beesley, J., Pickett, H. A., Johnatty, S. E., Dunning, A. M., Chen, X., Li, J., Michailidou, K., Lu, Y., Rider, D. N., Palmieri, R. T., Stutz, M. D., Lambrechts, D., Despierre, E., Lambrechts, S., Vergote, I., Chang-Claude, J., Nickels, S., Vrieling, A., Flesch-Janys, D., ... Consortium, O. C. A. (2011). Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers. PLOS ONE, 6(9), 24987. [9]. http://www.ncbi.nlm.nih.gov/pubmed/21949822?dopt=Citation

Vancouver

Beesley J, Pickett HA, Johnatty SE, Dunning AM, Chen X, Li J et al. Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers. PLOS ONE. 2011;6(9):24987. 9.

Bibtex

@article{04accb4abf0f494590a1a6e2ffc83eb3,
title = "Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers.",
abstract = "Genetic variation at the TERT-CLPTM1L locus at 5p15.33 is associated with susceptibility to several cancers, including epithelial ovarian cancer (EOC). We have carried out fine-mapping of this region in EOC which implicates an association with a single nucleotide polymorphism (SNP) within the TERT promoter. We demonstrate that the minor alleles at rs2736109, and at an additional TERT promoter SNP, rs2736108, are associated with decreased breast cancer risk, and that the combination of both SNPs substantially reduces TERT promoter activity.",
keywords = "Humans, Female, Prognosis, Case-Control Studies, Breast Neoplasms/*genetics, Polymorphism, Single Nucleotide/*genetics, Telomerase/*genetics, Cystadenocarcinoma, Serous/*genetics, Neoplasms, Glandular and Epithelial/*genetics, Ovarian Neoplasms/*genetics, Humans, Female, Prognosis, Case-Control Studies, Breast Neoplasms/*genetics, Polymorphism, Single Nucleotide/*genetics, Telomerase/*genetics, Cystadenocarcinoma, Serous/*genetics, Neoplasms, Glandular and Epithelial/*genetics, Ovarian Neoplasms/*genetics",
author = "Jonathan Beesley and Pickett, {Hilda A} and Johnatty, {Sharon E} and Dunning, {Alison M} and Xiaoqing Chen and Jun Li and Kyriaki Michailidou and Yi Lu and Rider, {David N} and Palmieri, {Rachel T} and Stutz, {Michael D} and Diether Lambrechts and Evelyn Despierre and Sandrina Lambrechts and Ignace Vergote and Jenny Chang-Claude and Stefan Nickels and Alina Vrieling and Dieter Flesch-Janys and Shan Wang-Gohrke and Ursula Eilber and Natalia Bogdanova and Natalia Antonenkova and Runnebaum, {Ingo B} and Thilo D{\"o}rk and Goodman, {Marc T} and Galina Lurie and Wilkens, {Lynne R} and Matsuno, {Rayna K} and Kiemeney, {Lambertus A} and Aben, {Katja K H} and Tamara Marees and Massuger, {Leon F A G} and Fridley, {Brooke L} and Vierkant, {Robert A} and Bandera, {Elisa V} and Olson, {Sara H} and Irene Orlow and Lorna Rodriguez-Rodriguez and Cook, {Linda S} and Le, {Nhu D} and Angela Brooks-Wilson and Kelemen, {Linda E} and Ian Campbell and Gayther, {Simon A} and Ramus, {Susan J} and Aleksandra Gentry-Maharaj and Usha Menon and Shahana Ahmed and Caroline Baynes and Pharoah, {Paul D} and Group, {Australian Ovarian Cancer Study} and ABCTB Investigators and Kenneth Muir and Artitaya Lophatananon and Arkom Chaiwerawattana and Surapon Wiangnon and Stuart Macgregor and Easton, {Douglas F} and Reddel, {Roger R} and Goode, {Ellen L} and Georgia Chenevix-Trench and Consortium, {Ovarian Cancer Association}",
year = "2011",
language = "English",
volume = "6",
pages = "24987",
journal = "PLOS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "9",

}

RIS

TY - JOUR

T1 - Functional polymorphisms in the TERT promoter are associated with risk of serous epithelial ovarian and breast cancers.

AU - Beesley, Jonathan

AU - Pickett, Hilda A

AU - Johnatty, Sharon E

AU - Dunning, Alison M

AU - Chen, Xiaoqing

AU - Li, Jun

AU - Michailidou, Kyriaki

AU - Lu, Yi

AU - Rider, David N

AU - Palmieri, Rachel T

AU - Stutz, Michael D

AU - Lambrechts, Diether

AU - Despierre, Evelyn

AU - Lambrechts, Sandrina

AU - Vergote, Ignace

AU - Chang-Claude, Jenny

AU - Nickels, Stefan

AU - Vrieling, Alina

AU - Flesch-Janys, Dieter

AU - Wang-Gohrke, Shan

AU - Eilber, Ursula

AU - Bogdanova, Natalia

AU - Antonenkova, Natalia

AU - Runnebaum, Ingo B

AU - Dörk, Thilo

AU - Goodman, Marc T

AU - Lurie, Galina

AU - Wilkens, Lynne R

AU - Matsuno, Rayna K

AU - Kiemeney, Lambertus A

AU - Aben, Katja K H

AU - Marees, Tamara

AU - Massuger, Leon F A G

AU - Fridley, Brooke L

AU - Vierkant, Robert A

AU - Bandera, Elisa V

AU - Olson, Sara H

AU - Orlow, Irene

AU - Rodriguez-Rodriguez, Lorna

AU - Cook, Linda S

AU - Le, Nhu D

AU - Brooks-Wilson, Angela

AU - Kelemen, Linda E

AU - Campbell, Ian

AU - Gayther, Simon A

AU - Ramus, Susan J

AU - Gentry-Maharaj, Aleksandra

AU - Menon, Usha

AU - Ahmed, Shahana

AU - Baynes, Caroline

AU - Pharoah, Paul D

AU - Group, Australian Ovarian Cancer Study

AU - Investigators, ABCTB

AU - Muir, Kenneth

AU - Lophatananon, Artitaya

AU - Chaiwerawattana, Arkom

AU - Wiangnon, Surapon

AU - Macgregor, Stuart

AU - Easton, Douglas F

AU - Reddel, Roger R

AU - Goode, Ellen L

AU - Chenevix-Trench, Georgia

AU - Consortium, Ovarian Cancer Association

PY - 2011

Y1 - 2011

N2 - Genetic variation at the TERT-CLPTM1L locus at 5p15.33 is associated with susceptibility to several cancers, including epithelial ovarian cancer (EOC). We have carried out fine-mapping of this region in EOC which implicates an association with a single nucleotide polymorphism (SNP) within the TERT promoter. We demonstrate that the minor alleles at rs2736109, and at an additional TERT promoter SNP, rs2736108, are associated with decreased breast cancer risk, and that the combination of both SNPs substantially reduces TERT promoter activity.

AB - Genetic variation at the TERT-CLPTM1L locus at 5p15.33 is associated with susceptibility to several cancers, including epithelial ovarian cancer (EOC). We have carried out fine-mapping of this region in EOC which implicates an association with a single nucleotide polymorphism (SNP) within the TERT promoter. We demonstrate that the minor alleles at rs2736109, and at an additional TERT promoter SNP, rs2736108, are associated with decreased breast cancer risk, and that the combination of both SNPs substantially reduces TERT promoter activity.

KW - Humans

KW - Female

KW - Prognosis

KW - Case-Control Studies

KW - Breast Neoplasms/genetics

KW - Polymorphism, Single Nucleotide/genetics

KW - Telomerase/genetics

KW - Cystadenocarcinoma, Serous/genetics

KW - Neoplasms, Glandular and Epithelial/genetics

KW - Ovarian Neoplasms/genetics

KW - Humans

KW - Female

KW - Prognosis

KW - Case-Control Studies

KW - Breast Neoplasms/genetics

KW - Polymorphism, Single Nucleotide/genetics

KW - Telomerase/genetics

KW - Cystadenocarcinoma, Serous/genetics

KW - Neoplasms, Glandular and Epithelial/genetics

KW - Ovarian Neoplasms/genetics

M3 - SCORING: Journal article

VL - 6

SP - 24987

JO - PLOS ONE

JF - PLOS ONE

SN - 1932-6203

IS - 9

M1 - 9

ER -