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Factors predicting survival after diagnosis of laryngeal cancer

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Factors predicting survival after diagnosis of laryngeal cancer. / Ramroth, Heribert; Schoeps, Anja; Rudolph, Elisabeth; Dyckhoff, Gerhard; Plinkert, Peter; Lippert, Burkhard; Feist, Klaus; Delank, Klaus-Wolfgang; Scheuermann, Klaus; Baier, Gerald; Ott, Ingo; Chenouda, Sami; Becher, Heiko; Dietz, Andreas.

in: ORAL ONCOL, Jahrgang 47, Nr. 12, 01.12.2011, S. 1154-8.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Ramroth, H, Schoeps, A, Rudolph, E, Dyckhoff, G, Plinkert, P, Lippert, B, Feist, K, Delank, K-W, Scheuermann, K, Baier, G, Ott, I, Chenouda, S, Becher, H & Dietz, A 2011, 'Factors predicting survival after diagnosis of laryngeal cancer', ORAL ONCOL, Jg. 47, Nr. 12, S. 1154-8. https://doi.org/10.1016/j.oraloncology.2011.08.003

APA

Ramroth, H., Schoeps, A., Rudolph, E., Dyckhoff, G., Plinkert, P., Lippert, B., Feist, K., Delank, K-W., Scheuermann, K., Baier, G., Ott, I., Chenouda, S., Becher, H., & Dietz, A. (2011). Factors predicting survival after diagnosis of laryngeal cancer. ORAL ONCOL, 47(12), 1154-8. https://doi.org/10.1016/j.oraloncology.2011.08.003

Vancouver

Ramroth H, Schoeps A, Rudolph E, Dyckhoff G, Plinkert P, Lippert B et al. Factors predicting survival after diagnosis of laryngeal cancer. ORAL ONCOL. 2011 Dez 1;47(12):1154-8. https://doi.org/10.1016/j.oraloncology.2011.08.003

Bibtex

@article{5f405633f073443797da6b935b99cf4f,
title = "Factors predicting survival after diagnosis of laryngeal cancer",
abstract = "Survival in patients with laryngeal cancer has not increased remarkably within the last years. It is presumed that a variety of factors act jointly in predicting survival after diagnosis: tumour stage, tumour site, treatment approaches, age and comorbidities. The aim of this German clinical multi-centre study is to present results from multivariate analysis. A retrospective cohort study was conducted in four hospitals in South-West Germany. Incident cases with laryngeal squamous cell carcinoma were included for the years 1998 to 2004, resulting in a population sample of 594 patients. Multivariate regression analysis was performed using the Cox proportional hazards model. Patients were followed up for 64.1months on average. Overall 5-year survival was 66% (95% confidence interval (CI): 62-70%). The strongest risk factors in multivariate analysis were age at first diagnosis (hazard ratio (HR): 1.5; 95% CI: 1.5-1.7 per each additional 10years), tumour stage, and the development of recurrences (HR 3.1; 95% CI: 2.3-4.2) or second primary carcinomas (HR 2.1; 95% CI: 1.4-3.1). A somewhat weaker effect was shown for patients with comorbidities (using Charlson's comorbidity index). The choice of treatment did not strongly affect survival when adjusting for other factors, possibly because the optimal treatment approach was applied for the specific constitution and requirements of each patient. For future research it would be desirable to study the effect of treatment on quality of life in multivariate analysis as well as other modifiable risk factors as smoking and drinking reduction or cessation after diagnosis.",
keywords = "Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell, Female, Follow-Up Studies, Germany, Humans, Laryngeal Neoplasms, Male, Middle Aged, Prognosis, Retrospective Studies, Risk Factors, Survival Analysis",
author = "Heribert Ramroth and Anja Schoeps and Elisabeth Rudolph and Gerhard Dyckhoff and Peter Plinkert and Burkhard Lippert and Klaus Feist and Klaus-Wolfgang Delank and Klaus Scheuermann and Gerald Baier and Ingo Ott and Sami Chenouda and Heiko Becher and Andreas Dietz",
note = "Copyright {\textcopyright} 2011 Elsevier Ltd. All rights reserved.",
year = "2011",
month = dec,
day = "1",
doi = "10.1016/j.oraloncology.2011.08.003",
language = "English",
volume = "47",
pages = "1154--8",
journal = "ORAL ONCOL",
issn = "1368-8375",
publisher = "Elsevier Limited",
number = "12",

}

RIS

TY - JOUR

T1 - Factors predicting survival after diagnosis of laryngeal cancer

AU - Ramroth, Heribert

AU - Schoeps, Anja

AU - Rudolph, Elisabeth

AU - Dyckhoff, Gerhard

AU - Plinkert, Peter

AU - Lippert, Burkhard

AU - Feist, Klaus

AU - Delank, Klaus-Wolfgang

AU - Scheuermann, Klaus

AU - Baier, Gerald

AU - Ott, Ingo

AU - Chenouda, Sami

AU - Becher, Heiko

AU - Dietz, Andreas

N1 - Copyright © 2011 Elsevier Ltd. All rights reserved.

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Survival in patients with laryngeal cancer has not increased remarkably within the last years. It is presumed that a variety of factors act jointly in predicting survival after diagnosis: tumour stage, tumour site, treatment approaches, age and comorbidities. The aim of this German clinical multi-centre study is to present results from multivariate analysis. A retrospective cohort study was conducted in four hospitals in South-West Germany. Incident cases with laryngeal squamous cell carcinoma were included for the years 1998 to 2004, resulting in a population sample of 594 patients. Multivariate regression analysis was performed using the Cox proportional hazards model. Patients were followed up for 64.1months on average. Overall 5-year survival was 66% (95% confidence interval (CI): 62-70%). The strongest risk factors in multivariate analysis were age at first diagnosis (hazard ratio (HR): 1.5; 95% CI: 1.5-1.7 per each additional 10years), tumour stage, and the development of recurrences (HR 3.1; 95% CI: 2.3-4.2) or second primary carcinomas (HR 2.1; 95% CI: 1.4-3.1). A somewhat weaker effect was shown for patients with comorbidities (using Charlson's comorbidity index). The choice of treatment did not strongly affect survival when adjusting for other factors, possibly because the optimal treatment approach was applied for the specific constitution and requirements of each patient. For future research it would be desirable to study the effect of treatment on quality of life in multivariate analysis as well as other modifiable risk factors as smoking and drinking reduction or cessation after diagnosis.

AB - Survival in patients with laryngeal cancer has not increased remarkably within the last years. It is presumed that a variety of factors act jointly in predicting survival after diagnosis: tumour stage, tumour site, treatment approaches, age and comorbidities. The aim of this German clinical multi-centre study is to present results from multivariate analysis. A retrospective cohort study was conducted in four hospitals in South-West Germany. Incident cases with laryngeal squamous cell carcinoma were included for the years 1998 to 2004, resulting in a population sample of 594 patients. Multivariate regression analysis was performed using the Cox proportional hazards model. Patients were followed up for 64.1months on average. Overall 5-year survival was 66% (95% confidence interval (CI): 62-70%). The strongest risk factors in multivariate analysis were age at first diagnosis (hazard ratio (HR): 1.5; 95% CI: 1.5-1.7 per each additional 10years), tumour stage, and the development of recurrences (HR 3.1; 95% CI: 2.3-4.2) or second primary carcinomas (HR 2.1; 95% CI: 1.4-3.1). A somewhat weaker effect was shown for patients with comorbidities (using Charlson's comorbidity index). The choice of treatment did not strongly affect survival when adjusting for other factors, possibly because the optimal treatment approach was applied for the specific constitution and requirements of each patient. For future research it would be desirable to study the effect of treatment on quality of life in multivariate analysis as well as other modifiable risk factors as smoking and drinking reduction or cessation after diagnosis.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Carcinoma, Squamous Cell

KW - Female

KW - Follow-Up Studies

KW - Germany

KW - Humans

KW - Laryngeal Neoplasms

KW - Male

KW - Middle Aged

KW - Prognosis

KW - Retrospective Studies

KW - Risk Factors

KW - Survival Analysis

U2 - 10.1016/j.oraloncology.2011.08.003

DO - 10.1016/j.oraloncology.2011.08.003

M3 - SCORING: Journal article

C2 - 21873105

VL - 47

SP - 1154

EP - 1158

JO - ORAL ONCOL

JF - ORAL ONCOL

SN - 1368-8375

IS - 12

ER -