Emotional arousal impairs association memory: roles of prefrontal cortex regions
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Emotional arousal impairs association memory: roles of prefrontal cortex regions. / Fujiwara, Esther; Madan, Christopher R; Caplan, Jeremy B; Sommer, Tobias.
in: LEARN MEMORY, Jahrgang 28, Nr. 3, 03.2021, S. 76-81.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Emotional arousal impairs association memory: roles of prefrontal cortex regions
AU - Fujiwara, Esther
AU - Madan, Christopher R
AU - Caplan, Jeremy B
AU - Sommer, Tobias
N1 - © 2021 Fujiwara et al.; Published by Cold Spring Harbor Laboratory Press.
PY - 2021/3
Y1 - 2021/3
N2 - The brain processes underlying impairing effects of emotional arousal on associative memory were previously attributed to two dissociable routes using high-resolution fMRI of the MTL (Madan et al. 2017). Extrahippocampal MTL regions supporting associative encoding of neutral pairs suggested unitization; conversely, associative encoding of negative pairs involved compensatory hippocampal activity. Here, whole-brain fMRI revealed prefrontal contributions: dmPFC was more involved in hippocampal-dependent negative pair learning and vmPFC in extrahippocampal neutral pair learning. Successful encoding of emotional memory associations may require emotion regulation/conflict resolution (dmPFC), while neutral memory associations may be accomplished by anchoring new information to prior knowledge (vmPFC).
AB - The brain processes underlying impairing effects of emotional arousal on associative memory were previously attributed to two dissociable routes using high-resolution fMRI of the MTL (Madan et al. 2017). Extrahippocampal MTL regions supporting associative encoding of neutral pairs suggested unitization; conversely, associative encoding of negative pairs involved compensatory hippocampal activity. Here, whole-brain fMRI revealed prefrontal contributions: dmPFC was more involved in hippocampal-dependent negative pair learning and vmPFC in extrahippocampal neutral pair learning. Successful encoding of emotional memory associations may require emotion regulation/conflict resolution (dmPFC), while neutral memory associations may be accomplished by anchoring new information to prior knowledge (vmPFC).
U2 - 10.1101/lm.052480.120
DO - 10.1101/lm.052480.120
M3 - SCORING: Journal article
C2 - 33593925
VL - 28
SP - 76
EP - 81
JO - LEARN MEMORY
JF - LEARN MEMORY
SN - 1072-0502
IS - 3
ER -