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Efficacy and Moderators of Internet-Based Interventions in Adults with Subthreshold Depression: An Individual Participant Data Meta-Analysis of Randomized Controlled Trials

Standard

Efficacy and Moderators of Internet-Based Interventions in Adults with Subthreshold Depression: An Individual Participant Data Meta-Analysis of Randomized Controlled Trials. / Reins, Jo Annika; Buntrock, Claudia; Zimmermann, Johannes; Grund, Simon; Harrer, Mathias; Lehr, Dirk; Baumeister, Harald; Weisel, Kiona; Domhardt, Matthias; Imamura, Kotaro; Kawakami, Norito; Spek, Viola; Nobis, Stephanie; Snoek, Frank; Cuijpers, Pim; Klein, Jan Philipp; Moritz, Steffen; Ebert, David Daniel.

in: PSYCHOTHER PSYCHOSOM, Jahrgang 90, Nr. 2, 2021, S. 94-106.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Reins, JA, Buntrock, C, Zimmermann, J, Grund, S, Harrer, M, Lehr, D, Baumeister, H, Weisel, K, Domhardt, M, Imamura, K, Kawakami, N, Spek, V, Nobis, S, Snoek, F, Cuijpers, P, Klein, JP, Moritz, S & Ebert, DD 2021, 'Efficacy and Moderators of Internet-Based Interventions in Adults with Subthreshold Depression: An Individual Participant Data Meta-Analysis of Randomized Controlled Trials', PSYCHOTHER PSYCHOSOM, Jg. 90, Nr. 2, S. 94-106. https://doi.org/10.1159/000507819

APA

Reins, J. A., Buntrock, C., Zimmermann, J., Grund, S., Harrer, M., Lehr, D., Baumeister, H., Weisel, K., Domhardt, M., Imamura, K., Kawakami, N., Spek, V., Nobis, S., Snoek, F., Cuijpers, P., Klein, J. P., Moritz, S., & Ebert, D. D. (2021). Efficacy and Moderators of Internet-Based Interventions in Adults with Subthreshold Depression: An Individual Participant Data Meta-Analysis of Randomized Controlled Trials. PSYCHOTHER PSYCHOSOM, 90(2), 94-106. https://doi.org/10.1159/000507819

Vancouver

Reins JA, Buntrock C, Zimmermann J, Grund S, Harrer M, Lehr D et al. Efficacy and Moderators of Internet-Based Interventions in Adults with Subthreshold Depression: An Individual Participant Data Meta-Analysis of Randomized Controlled Trials. PSYCHOTHER PSYCHOSOM. 2021;90(2):94-106. https://doi.org/10.1159/000507819

Bibtex

@article{f1ad0a50a3f845cbb09134d28ef4270a,
title = "Efficacy and Moderators of Internet-Based Interventions in Adults with Subthreshold Depression: An Individual Participant Data Meta-Analysis of Randomized Controlled Trials",
abstract = "INTRODUCTION: Evidence on effects of Internet-based interventions to treat subthreshold depression (sD) and prevent the onset of major depression (MDD) is inconsistent.OBJECTIVE: We conducted an individual participant data meta-analysis to determine differences between intervention and control groups (IG, CG) in depressive symptom severity (DSS), treatment response, close to symptom-free status, symptom deterioration and MDD onset as well as moderators of intervention outcomes.METHODS: Randomized controlled trials were identified through systematic searches via PubMed, PsycINFO, Embase and Cochrane Library. Multilevel regression analyses were used to examine efficacy and moderators.RESULTS: Seven trials (2,186 participants) were included. The IG was superior in DSS at all measurement points (posttreatment: 6-12 weeks; Hedges' g = 0.39 [95% CI: 0.25-0.53]; follow-up 1: 3-6 months; g = 0.30 [95% CI: 0.15-0.45]; follow-up 2: 12 months, g = 0.27 [95% CI: 0.07-0.47], compared with the CG. Significantly more participants in the IG than in the CG reached response and close to symptom-free status at all measurement points. A significant difference in symptom deterioration between the groups was found at the posttreatment assessment and follow-up 2. Incidence rates for MDD onset within 12 months were lower in the IG (19%) than in the CG (26%). Higher initial DSS and older age were identified as moderators of intervention effect on DSS.CONCLUSIONS: Our findings provide evidence for Internet-based interventions to be a suitable low-threshold intervention to treat individuals with sD and to reduce the incidence of MDD. This might be particularly true for older people with a substantial symptom burden.noch nicht ver{\"o}ffentlicht (gez.Sarah)",
author = "Reins, {Jo Annika} and Claudia Buntrock and Johannes Zimmermann and Simon Grund and Mathias Harrer and Dirk Lehr and Harald Baumeister and Kiona Weisel and Matthias Domhardt and Kotaro Imamura and Norito Kawakami and Viola Spek and Stephanie Nobis and Frank Snoek and Pim Cuijpers and Klein, {Jan Philipp} and Steffen Moritz and Ebert, {David Daniel}",
note = "{\textcopyright} 2020 The Author(s) Published by S. Karger AG, Basel.",
year = "2021",
doi = "10.1159/000507819",
language = "English",
volume = "90",
pages = "94--106",
journal = "PSYCHOTHER PSYCHOSOM",
issn = "0033-3190",
publisher = "S. Karger AG",
number = "2",

}

RIS

TY - JOUR

T1 - Efficacy and Moderators of Internet-Based Interventions in Adults with Subthreshold Depression: An Individual Participant Data Meta-Analysis of Randomized Controlled Trials

AU - Reins, Jo Annika

AU - Buntrock, Claudia

AU - Zimmermann, Johannes

AU - Grund, Simon

AU - Harrer, Mathias

AU - Lehr, Dirk

AU - Baumeister, Harald

AU - Weisel, Kiona

AU - Domhardt, Matthias

AU - Imamura, Kotaro

AU - Kawakami, Norito

AU - Spek, Viola

AU - Nobis, Stephanie

AU - Snoek, Frank

AU - Cuijpers, Pim

AU - Klein, Jan Philipp

AU - Moritz, Steffen

AU - Ebert, David Daniel

N1 - © 2020 The Author(s) Published by S. Karger AG, Basel.

PY - 2021

Y1 - 2021

N2 - INTRODUCTION: Evidence on effects of Internet-based interventions to treat subthreshold depression (sD) and prevent the onset of major depression (MDD) is inconsistent.OBJECTIVE: We conducted an individual participant data meta-analysis to determine differences between intervention and control groups (IG, CG) in depressive symptom severity (DSS), treatment response, close to symptom-free status, symptom deterioration and MDD onset as well as moderators of intervention outcomes.METHODS: Randomized controlled trials were identified through systematic searches via PubMed, PsycINFO, Embase and Cochrane Library. Multilevel regression analyses were used to examine efficacy and moderators.RESULTS: Seven trials (2,186 participants) were included. The IG was superior in DSS at all measurement points (posttreatment: 6-12 weeks; Hedges' g = 0.39 [95% CI: 0.25-0.53]; follow-up 1: 3-6 months; g = 0.30 [95% CI: 0.15-0.45]; follow-up 2: 12 months, g = 0.27 [95% CI: 0.07-0.47], compared with the CG. Significantly more participants in the IG than in the CG reached response and close to symptom-free status at all measurement points. A significant difference in symptom deterioration between the groups was found at the posttreatment assessment and follow-up 2. Incidence rates for MDD onset within 12 months were lower in the IG (19%) than in the CG (26%). Higher initial DSS and older age were identified as moderators of intervention effect on DSS.CONCLUSIONS: Our findings provide evidence for Internet-based interventions to be a suitable low-threshold intervention to treat individuals with sD and to reduce the incidence of MDD. This might be particularly true for older people with a substantial symptom burden.noch nicht veröffentlicht (gez.Sarah)

AB - INTRODUCTION: Evidence on effects of Internet-based interventions to treat subthreshold depression (sD) and prevent the onset of major depression (MDD) is inconsistent.OBJECTIVE: We conducted an individual participant data meta-analysis to determine differences between intervention and control groups (IG, CG) in depressive symptom severity (DSS), treatment response, close to symptom-free status, symptom deterioration and MDD onset as well as moderators of intervention outcomes.METHODS: Randomized controlled trials were identified through systematic searches via PubMed, PsycINFO, Embase and Cochrane Library. Multilevel regression analyses were used to examine efficacy and moderators.RESULTS: Seven trials (2,186 participants) were included. The IG was superior in DSS at all measurement points (posttreatment: 6-12 weeks; Hedges' g = 0.39 [95% CI: 0.25-0.53]; follow-up 1: 3-6 months; g = 0.30 [95% CI: 0.15-0.45]; follow-up 2: 12 months, g = 0.27 [95% CI: 0.07-0.47], compared with the CG. Significantly more participants in the IG than in the CG reached response and close to symptom-free status at all measurement points. A significant difference in symptom deterioration between the groups was found at the posttreatment assessment and follow-up 2. Incidence rates for MDD onset within 12 months were lower in the IG (19%) than in the CG (26%). Higher initial DSS and older age were identified as moderators of intervention effect on DSS.CONCLUSIONS: Our findings provide evidence for Internet-based interventions to be a suitable low-threshold intervention to treat individuals with sD and to reduce the incidence of MDD. This might be particularly true for older people with a substantial symptom burden.noch nicht veröffentlicht (gez.Sarah)

U2 - 10.1159/000507819

DO - 10.1159/000507819

M3 - SCORING: Journal article

C2 - 32544912

VL - 90

SP - 94

EP - 106

JO - PSYCHOTHER PSYCHOSOM

JF - PSYCHOTHER PSYCHOSOM

SN - 0033-3190

IS - 2

ER -