Effects of chronic posttraumatic stress disorder on metabolic risk, quality of life, and stress hormones in aging former refugee children.
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Effects of chronic posttraumatic stress disorder on metabolic risk, quality of life, and stress hormones in aging former refugee children. / Muhtz, Christoph; Godemann, Kathrin; von Alm, Christine; Wittekind, Charlotte; Goemann, Christoph; Wiedemann, Klaus; Yassouridis, Alexander; Kellner, Michael.
in: J NERV MENT DIS, Jahrgang 199, Nr. 9, 9, 2011, S. 646-652.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Effects of chronic posttraumatic stress disorder on metabolic risk, quality of life, and stress hormones in aging former refugee children.
AU - Muhtz, Christoph
AU - Godemann, Kathrin
AU - von Alm, Christine
AU - Wittekind, Charlotte
AU - Goemann, Christoph
AU - Wiedemann, Klaus
AU - Yassouridis, Alexander
AU - Kellner, Michael
PY - 2011
Y1 - 2011
N2 - It is still unclear whether the association between traumatic stress and physical disease is mediated by posttraumatic stress disorder (PTSD). Therefore, we examined the long-term consequences of PTSD on cardiovascular risk, stress hormones, and quality of life in a sample of former refugee children who were severely traumatized more than six decades ago. In 25 subjects with chronic PTSD and 25 trauma-controlled subjects, we measured the variables of metabolic syndrome supplemented by the ankle-brachial index and highly sensitive C-reactive protein. Quality of life was assessed using the 36-item Short-Form Health Survey. Cortisol, adrenocorticotropin-releasing hormone (ACTH), and dehydroepiandrosterone (DHEA) were measured using the low-dose-dexamethasone suppression test. In addition, salivary cortisol was assessed at 8:00 a.m., 12:00 p.m., 4:00 p.m., and 8:00 p.m. We found a significant group effect between participants with and without PTSD regarding quality of life but not in any metabolic parameter including the ankle-brachial index or cortisol, ACTH, and DHEA in plasma before and after dexamethasone or salivary cortisol. The postulated association between traumatic stress and physical illness does not appear to be mediated by PTSD in this population. Nevertheless, the search for subgroups of PTSD patients with childhood traumatization leading to different metabolic and endocrine long-term consequences in aging PTSD patients is needed.
AB - It is still unclear whether the association between traumatic stress and physical disease is mediated by posttraumatic stress disorder (PTSD). Therefore, we examined the long-term consequences of PTSD on cardiovascular risk, stress hormones, and quality of life in a sample of former refugee children who were severely traumatized more than six decades ago. In 25 subjects with chronic PTSD and 25 trauma-controlled subjects, we measured the variables of metabolic syndrome supplemented by the ankle-brachial index and highly sensitive C-reactive protein. Quality of life was assessed using the 36-item Short-Form Health Survey. Cortisol, adrenocorticotropin-releasing hormone (ACTH), and dehydroepiandrosterone (DHEA) were measured using the low-dose-dexamethasone suppression test. In addition, salivary cortisol was assessed at 8:00 a.m., 12:00 p.m., 4:00 p.m., and 8:00 p.m. We found a significant group effect between participants with and without PTSD regarding quality of life but not in any metabolic parameter including the ankle-brachial index or cortisol, ACTH, and DHEA in plasma before and after dexamethasone or salivary cortisol. The postulated association between traumatic stress and physical illness does not appear to be mediated by PTSD in this population. Nevertheless, the search for subgroups of PTSD patients with childhood traumatization leading to different metabolic and endocrine long-term consequences in aging PTSD patients is needed.
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Questionnaires
KW - Health Surveys
KW - Social Support
KW - Adrenocorticotropic Hormone/blood
KW - Ankle Brachial Index
KW - C-Reactive Protein/metabolism
KW - Dehydroepiandrosterone/blood
KW - Hydrocortisone/metabolism
KW - Life Change Events
KW - Quality of Life/psychology
KW - Refugees/psychology
KW - Saliva/metabolism
KW - Stress Disorders, Post-Traumatic/metabolism/psychology
KW - Humans
KW - Male
KW - Aged
KW - Female
KW - Questionnaires
KW - Health Surveys
KW - Social Support
KW - Adrenocorticotropic Hormone/blood
KW - Ankle Brachial Index
KW - C-Reactive Protein/metabolism
KW - Dehydroepiandrosterone/blood
KW - Hydrocortisone/metabolism
KW - Life Change Events
KW - Quality of Life/psychology
KW - Refugees/psychology
KW - Saliva/metabolism
KW - Stress Disorders, Post-Traumatic/metabolism/psychology
M3 - SCORING: Journal article
VL - 199
SP - 646
EP - 652
JO - J NERV MENT DIS
JF - J NERV MENT DIS
SN - 0022-3018
IS - 9
M1 - 9
ER -
