Donor heparinization is not a contraindication to liver transplantation even in recipients with acute heparin-induced thrombocytopenia type II
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Donor heparinization is not a contraindication to liver transplantation even in recipients with acute heparin-induced thrombocytopenia type II : a case report and review of the literature. / Bachmann, R; Nadalin, S; Lange, J; Ladurner, R; Königsrainer, A; Heininger, A.
in: TRANSPL INT, Jahrgang 24, Nr. 10, 10.2011, S. e89-92.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Donor heparinization is not a contraindication to liver transplantation even in recipients with acute heparin-induced thrombocytopenia type II
T2 - a case report and review of the literature
AU - Bachmann, R
AU - Nadalin, S
AU - Lange, J
AU - Ladurner, R
AU - Königsrainer, A
AU - Heininger, A
N1 - © 2011 The Authors. Transplant International © 2011 European Society for Organ Transplantation.
PY - 2011/10
Y1 - 2011/10
N2 - Heparin-induced thrombocytopenia (HIT) type II is caused by an immune-mediated side effect of heparin anticoagulation resulting in a clotting disorder. In the setting of urgent liver transplantation, the question arises whether a graft from a heparinized donor can be safely transplantated in a recipient with even acute heparin-induced thrombocytopenia type II. We report on a patient with end-stage liver disease and acute HIT II waiting for liver transplantation. Despite the risk of life-threatening complications, an organ procured from a heparinized donor was accepted. Assuming heparin residuals within the graft, the donor organ was flushed backtable with increased amounts of Wisconsin solution. The subsequent transplantation and the postoperative course were uneventful; neither thromboses nor graft dysfunction occurred. Even in acute episode of HIT II with circulating antibodies, a patient may receive an organ from a heparin-treated donor, if adequate precautions during organ preparation are observed.
AB - Heparin-induced thrombocytopenia (HIT) type II is caused by an immune-mediated side effect of heparin anticoagulation resulting in a clotting disorder. In the setting of urgent liver transplantation, the question arises whether a graft from a heparinized donor can be safely transplantated in a recipient with even acute heparin-induced thrombocytopenia type II. We report on a patient with end-stage liver disease and acute HIT II waiting for liver transplantation. Despite the risk of life-threatening complications, an organ procured from a heparinized donor was accepted. Assuming heparin residuals within the graft, the donor organ was flushed backtable with increased amounts of Wisconsin solution. The subsequent transplantation and the postoperative course were uneventful; neither thromboses nor graft dysfunction occurred. Even in acute episode of HIT II with circulating antibodies, a patient may receive an organ from a heparin-treated donor, if adequate precautions during organ preparation are observed.
KW - Acute Disease
KW - Anticoagulants
KW - End Stage Liver Disease
KW - Female
KW - Heparin
KW - Humans
KW - Liver Function Tests
KW - Liver Transplantation
KW - Middle Aged
KW - Platelet Count
KW - Risk
KW - Thrombocytopenia
KW - Thrombosis
KW - Time Factors
KW - Treatment Outcome
KW - Venous Thrombosis
KW - Case Reports
KW - Journal Article
U2 - 10.1111/j.1432-2277.2011.01323.x
DO - 10.1111/j.1432-2277.2011.01323.x
M3 - SCORING: Journal article
C2 - 21884552
VL - 24
SP - e89-92
JO - TRANSPL INT
JF - TRANSPL INT
SN - 0934-0874
IS - 10
ER -
