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Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow

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Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow. / Riedel, René; Addo, Richard; Ferreira-Gomes, Marta; Heinz, Gitta Anne; Heinrich, Frederik; Kummer, Jannis; Greiff, Victor; Schulz, Daniel; Klaeden, Cora; Cornelis, Rebecca; Menzel, Ulrike; Kröger, Stefan; Stervbo, Ulrik; Köhler, Ralf; Haftmann, Claudia; Kühnel, Silvia; Lehmann, Katrin; Maschmeyer, Patrick; McGrath, Mairi; Naundorf, Sandra; Hahne, Stefanie; Sercan-Alp, Özen; Siracusa, Francesco; Stefanowski, Jonathan; Weber, Melanie; Westendorf, Kerstin; Zimmermann, Jakob; Hauser, Anja E; Reddy, Sai T; Durek, Pawel; Chang, Hyun-Dong; Mashreghi, Mir-Farzin; Radbruch, Andreas.

in: NAT COMMUN, Jahrgang 11, Nr. 1, 2570, 22.05.2020.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Riedel, R, Addo, R, Ferreira-Gomes, M, Heinz, GA, Heinrich, F, Kummer, J, Greiff, V, Schulz, D, Klaeden, C, Cornelis, R, Menzel, U, Kröger, S, Stervbo, U, Köhler, R, Haftmann, C, Kühnel, S, Lehmann, K, Maschmeyer, P, McGrath, M, Naundorf, S, Hahne, S, Sercan-Alp, Ö, Siracusa, F, Stefanowski, J, Weber, M, Westendorf, K, Zimmermann, J, Hauser, AE, Reddy, ST, Durek, P, Chang, H-D, Mashreghi, M-F & Radbruch, A 2020, 'Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow', NAT COMMUN, Jg. 11, Nr. 1, 2570. https://doi.org/10.1038/s41467-020-16464-6

APA

Riedel, R., Addo, R., Ferreira-Gomes, M., Heinz, G. A., Heinrich, F., Kummer, J., Greiff, V., Schulz, D., Klaeden, C., Cornelis, R., Menzel, U., Kröger, S., Stervbo, U., Köhler, R., Haftmann, C., Kühnel, S., Lehmann, K., Maschmeyer, P., McGrath, M., ... Radbruch, A. (2020). Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow. NAT COMMUN, 11(1), [2570]. https://doi.org/10.1038/s41467-020-16464-6

Vancouver

Riedel R, Addo R, Ferreira-Gomes M, Heinz GA, Heinrich F, Kummer J et al. Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow. NAT COMMUN. 2020 Mai 22;11(1). 2570. https://doi.org/10.1038/s41467-020-16464-6

Bibtex

@article{a623530c79a84ed682a15af5cc797462,
title = "Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow",
abstract = "At present, it is not clear how memory B lymphocytes are maintained over time, and whether only as circulating cells or also residing in particular tissues. Here we describe distinct populations of isotype-switched memory B lymphocytes (Bsm) of murine spleen and bone marrow, identified according to individual transcriptional signature and B cell receptor repertoire. A population of marginal zone-like cells is located exclusively in the spleen, while a population of quiescent Bsm is found only in the bone marrow. Three further resident populations, present in spleen and bone marrow, represent transitional and follicular B cells and B1 cells, respectively. A population representing 10-20% of spleen and bone marrow memory B cells is the only one qualifying as circulating. In the bone marrow, all cells individually dock onto VCAM1+ stromal cells and, reminiscent of resident memory T and plasma cells, are void of activation, proliferation and mobility.",
keywords = "Adjuvants, Immunologic/pharmacology, Animals, Animals, Wild/immunology, B-Lymphocytes/cytology, Bone Marrow Cells/cytology, Cell Cycle, Cell Proliferation/genetics, Gene Expression Regulation/immunology, Immunoglobulin Class Switching, Immunologic Memory, Mice, Inbred C57BL, Mice, Transgenic, Receptors, Antigen, B-Cell/genetics, Spleen/cytology, Stromal Cells/cytology, Vascular Cell Adhesion Molecule-1/metabolism",
author = "Ren{\'e} Riedel and Richard Addo and Marta Ferreira-Gomes and Heinz, {Gitta Anne} and Frederik Heinrich and Jannis Kummer and Victor Greiff and Daniel Schulz and Cora Klaeden and Rebecca Cornelis and Ulrike Menzel and Stefan Kr{\"o}ger and Ulrik Stervbo and Ralf K{\"o}hler and Claudia Haftmann and Silvia K{\"u}hnel and Katrin Lehmann and Patrick Maschmeyer and Mairi McGrath and Sandra Naundorf and Stefanie Hahne and {\"O}zen Sercan-Alp and Francesco Siracusa and Jonathan Stefanowski and Melanie Weber and Kerstin Westendorf and Jakob Zimmermann and Hauser, {Anja E} and Reddy, {Sai T} and Pawel Durek and Hyun-Dong Chang and Mir-Farzin Mashreghi and Andreas Radbruch",
year = "2020",
month = may,
day = "22",
doi = "10.1038/s41467-020-16464-6",
language = "English",
volume = "11",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Discrete populations of isotype-switched memory B lymphocytes are maintained in murine spleen and bone marrow

AU - Riedel, René

AU - Addo, Richard

AU - Ferreira-Gomes, Marta

AU - Heinz, Gitta Anne

AU - Heinrich, Frederik

AU - Kummer, Jannis

AU - Greiff, Victor

AU - Schulz, Daniel

AU - Klaeden, Cora

AU - Cornelis, Rebecca

AU - Menzel, Ulrike

AU - Kröger, Stefan

AU - Stervbo, Ulrik

AU - Köhler, Ralf

AU - Haftmann, Claudia

AU - Kühnel, Silvia

AU - Lehmann, Katrin

AU - Maschmeyer, Patrick

AU - McGrath, Mairi

AU - Naundorf, Sandra

AU - Hahne, Stefanie

AU - Sercan-Alp, Özen

AU - Siracusa, Francesco

AU - Stefanowski, Jonathan

AU - Weber, Melanie

AU - Westendorf, Kerstin

AU - Zimmermann, Jakob

AU - Hauser, Anja E

AU - Reddy, Sai T

AU - Durek, Pawel

AU - Chang, Hyun-Dong

AU - Mashreghi, Mir-Farzin

AU - Radbruch, Andreas

PY - 2020/5/22

Y1 - 2020/5/22

N2 - At present, it is not clear how memory B lymphocytes are maintained over time, and whether only as circulating cells or also residing in particular tissues. Here we describe distinct populations of isotype-switched memory B lymphocytes (Bsm) of murine spleen and bone marrow, identified according to individual transcriptional signature and B cell receptor repertoire. A population of marginal zone-like cells is located exclusively in the spleen, while a population of quiescent Bsm is found only in the bone marrow. Three further resident populations, present in spleen and bone marrow, represent transitional and follicular B cells and B1 cells, respectively. A population representing 10-20% of spleen and bone marrow memory B cells is the only one qualifying as circulating. In the bone marrow, all cells individually dock onto VCAM1+ stromal cells and, reminiscent of resident memory T and plasma cells, are void of activation, proliferation and mobility.

AB - At present, it is not clear how memory B lymphocytes are maintained over time, and whether only as circulating cells or also residing in particular tissues. Here we describe distinct populations of isotype-switched memory B lymphocytes (Bsm) of murine spleen and bone marrow, identified according to individual transcriptional signature and B cell receptor repertoire. A population of marginal zone-like cells is located exclusively in the spleen, while a population of quiescent Bsm is found only in the bone marrow. Three further resident populations, present in spleen and bone marrow, represent transitional and follicular B cells and B1 cells, respectively. A population representing 10-20% of spleen and bone marrow memory B cells is the only one qualifying as circulating. In the bone marrow, all cells individually dock onto VCAM1+ stromal cells and, reminiscent of resident memory T and plasma cells, are void of activation, proliferation and mobility.

KW - Adjuvants, Immunologic/pharmacology

KW - Animals

KW - Animals, Wild/immunology

KW - B-Lymphocytes/cytology

KW - Bone Marrow Cells/cytology

KW - Cell Cycle

KW - Cell Proliferation/genetics

KW - Gene Expression Regulation/immunology

KW - Immunoglobulin Class Switching

KW - Immunologic Memory

KW - Mice, Inbred C57BL

KW - Mice, Transgenic

KW - Receptors, Antigen, B-Cell/genetics

KW - Spleen/cytology

KW - Stromal Cells/cytology

KW - Vascular Cell Adhesion Molecule-1/metabolism

U2 - 10.1038/s41467-020-16464-6

DO - 10.1038/s41467-020-16464-6

M3 - SCORING: Journal article

C2 - 32444631

VL - 11

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

M1 - 2570

ER -