Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine.

Xinli Hu; Dorothee Atzler; Xin Xu; Ping Zhang; Haipeng Guo; Zhongbing Lu; John Fassett; Edzard Schwedhelm; Rainer Böger; Robert J Bache; Yingjie Chen

Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine.

Standard

Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine. / Hu, Xinli; Atzler, Dorothee; Xu, Xin; Zhang, Ping; Guo, Haipeng; Lu, Zhongbing; Fassett, John; Schwedhelm, Edzard ; Böger, Rainer; Bache, Robert J; Chen, Yingjie.

in: ARTERIOSCL THROM VAS, Jahrgang 31, Nr. 7, 7, 2011, S. 1540-1546.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Hu, X, Atzler, D, Xu, X, Zhang, P, Guo, H, Lu, Z, Fassett, J, Schwedhelm, E , Böger, R, Bache, RJ & Chen, Y 2011, 'Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine.', ARTERIOSCL THROM VAS, Jg. 31, Nr. 7, 7, S. 1540-1546. <http://www.ncbi.nlm.nih.gov/pubmed/21493890?dopt=Citation>

APA

Hu, X., Atzler, D., Xu, X., Zhang, P., Guo, H., Lu, Z., Fassett, J., Schwedhelm, E., Böger, R., Bache, R. J., & Chen, Y. (2011). Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine. ARTERIOSCL THROM VAS, 31(7), 1540-1546. [7]. http://www.ncbi.nlm.nih.gov/pubmed/21493890?dopt=Citation

Vancouver

Hu X, Atzler D, Xu X, Zhang P, Guo H, Lu Z et al. Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine. ARTERIOSCL THROM VAS. 2011;31(7):1540-1546. 7.

Bibtex

@article{51c42434458548539a69d700889a9f87,

title = "Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine.",

abstract = "The objective of this study was to identify the role of dimethylarginine dimethylaminohydrolase-1 (DDAH1) in degrading the endogenous nitric oxide synthase inhibitors asymmetrical dimethylarginine (ADMA) and N(g)-monomethyl-L-arginine (L-NMMA).",

keywords = "Animals, Male, Female, Risk Factors, Time Factors, Genotype, Cells, Cultured, Mice, Mice, Knockout, Phenotype, Substrate Specificity, Transfection, Infusion Pumps, Implantable, RNA Interference, Blood Pressure, Nitric Oxide/metabolism, Amidohydrolases/deficiency/genetics/*metabolism, Arginine/*analogs & derivatives/blood/metabolism, Cardiovascular Diseases/enzymology/*etiology/genetics, Endothelial Cells/*enzymology, Enzyme Inhibitors/administration & dosage, Hypertension/enzymology/physiopathology, Mice, 129 Strain, NG-Nitroarginine Methyl Ester/administration & dosage, Nitric Oxide Synthase/antagonists & inhibitors/metabolism, omega-N-Methylarginine/metabolism, Animals, Male, Female, Risk Factors, Time Factors, Genotype, Cells, Cultured, Mice, Mice, Knockout, Phenotype, Substrate Specificity, Transfection, Infusion Pumps, Implantable, RNA Interference, Blood Pressure, Nitric Oxide/metabolism, Amidohydrolases/deficiency/genetics/*metabolism, Arginine/*analogs & derivatives/blood/metabolism, Cardiovascular Diseases/enzymology/*etiology/genetics, Endothelial Cells/*enzymology, Enzyme Inhibitors/administration & dosage, Hypertension/enzymology/physiopathology, Mice, 129 Strain, NG-Nitroarginine Methyl Ester/administration & dosage, Nitric Oxide Synthase/antagonists & inhibitors/metabolism, omega-N-Methylarginine/metabolism",

author = "Xinli Hu and Dorothee Atzler and Xin Xu and Ping Zhang and Haipeng Guo and Zhongbing Lu and John Fassett and Edzard Schwedhelm and Rainer B{\"o}ger and Bache, {Robert J} and Yingjie Chen",

year = "2011",

language = "English",

volume = "31",

pages = "1540--1546",

journal = "ARTERIOSCL THROM VAS",

issn = "1079-5642",

publisher = "Lippincott Williams and Wilkins",

number = "7",

}

RIS

TY - JOUR

T1 - Dimethylarginine dimethylaminohydrolase-1 is the critical enzyme for degrading the cardiovascular risk factor asymmetrical dimethylarginine.

AU - Hu, Xinli

AU - Atzler, Dorothee

AU - Xu, Xin

AU - Zhang, Ping

AU - Guo, Haipeng

AU - Lu, Zhongbing

AU - Fassett, John

AU - Schwedhelm, Edzard

AU - Böger, Rainer

AU - Bache, Robert J

AU - Chen, Yingjie

PY - 2011

Y1 - 2011

N2 - The objective of this study was to identify the role of dimethylarginine dimethylaminohydrolase-1 (DDAH1) in degrading the endogenous nitric oxide synthase inhibitors asymmetrical dimethylarginine (ADMA) and N(g)-monomethyl-L-arginine (L-NMMA).

AB - The objective of this study was to identify the role of dimethylarginine dimethylaminohydrolase-1 (DDAH1) in degrading the endogenous nitric oxide synthase inhibitors asymmetrical dimethylarginine (ADMA) and N(g)-monomethyl-L-arginine (L-NMMA).

KW - Animals

KW - Male

KW - Female

KW - Risk Factors

KW - Time Factors

KW - Genotype

KW - Cells, Cultured

KW - Mice

KW - Mice, Knockout

KW - Phenotype

KW - Substrate Specificity

KW - Transfection

KW - Infusion Pumps, Implantable

KW - RNA Interference

KW - Blood Pressure

KW - Nitric Oxide/metabolism

KW - Amidohydrolases/deficiency/genetics/metabolism

KW - Arginine/analogs & derivatives/blood/metabolism

KW - Cardiovascular Diseases/enzymology/etiology/genetics

KW - Endothelial Cells/enzymology

KW - Enzyme Inhibitors/administration & dosage

KW - Hypertension/enzymology/physiopathology

KW - Mice, 129 Strain

KW - NG-Nitroarginine Methyl Ester/administration & dosage

KW - Nitric Oxide Synthase/antagonists & inhibitors/metabolism

KW - omega-N-Methylarginine/metabolism