Decreased cognitive functioning in patients with advanced oral squamous cell carcinoma
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Decreased cognitive functioning in patients with advanced oral squamous cell carcinoma. / Rohleder, Nils H; Wysluch, Andreas; Maurer, Peter; Wolff, Klaus-D; Wagenpfeil, Stefan; Kreutzer, Kilian; Hasler, Rafael; Wales, Craig J; Kesting, Marco R.
in: ORAL ONCOL, Jahrgang 47, Nr. 10, 10.2011, S. 993-7.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Decreased cognitive functioning in patients with advanced oral squamous cell carcinoma
AU - Rohleder, Nils H
AU - Wysluch, Andreas
AU - Maurer, Peter
AU - Wolff, Klaus-D
AU - Wagenpfeil, Stefan
AU - Kreutzer, Kilian
AU - Hasler, Rafael
AU - Wales, Craig J
AU - Kesting, Marco R
N1 - Copyright © 2011 Elsevier Ltd. All rights reserved.
PY - 2011/10
Y1 - 2011/10
N2 - Cognitive impairment causes a delay in diagnosis and treatment of the various cancer entities, resulting in reduced surgical outcomes and patient survival. However, no investigations have been carried out as to whether an association exists between cognitive functioning and tumour size in patients with oral squamous cell carcinoma (OSCC). In this study, 46 patients with OSCC were evaluated by using a screening test for dementia, consisting of a combination of the mini-mental state examination and the clock test (81% sensitivity and 90% specificity). Test scores were correlated with tumour size according to the TNM staging system, which was categorized as being either limited (T1, T2; n=24) or advanced (T3, T4; n=22). No difference in age (P=0.172), sex (P=0.330), the percentage of drinkers (P=0.090) or the percentage of smokers (P=0.484) was evident between the groups. Patients with advanced tumour size scored significantly lower (median 5.5 of 9 possible points) when compared with those having tumours of a limited size (median 9 of 9 possible points; P=0.005). The median score of patients with T3/T4 tumours suggested the need for comprehensive neuropsychological evaluations for dementia. In conclusion, this study has demonstrated the correlation of reduced cognitive functioning in patients with advanced OSCC. As a consequence, instructions for the identification of early signs and of symptoms of oral cancer are strongly recommended for relatives and nursing staff of patients with cognitive impairment. Such patients might need immediate treatment for oral cancer but might not be able to understand the significance of their symptoms and therefore present late, often too late.
AB - Cognitive impairment causes a delay in diagnosis and treatment of the various cancer entities, resulting in reduced surgical outcomes and patient survival. However, no investigations have been carried out as to whether an association exists between cognitive functioning and tumour size in patients with oral squamous cell carcinoma (OSCC). In this study, 46 patients with OSCC were evaluated by using a screening test for dementia, consisting of a combination of the mini-mental state examination and the clock test (81% sensitivity and 90% specificity). Test scores were correlated with tumour size according to the TNM staging system, which was categorized as being either limited (T1, T2; n=24) or advanced (T3, T4; n=22). No difference in age (P=0.172), sex (P=0.330), the percentage of drinkers (P=0.090) or the percentage of smokers (P=0.484) was evident between the groups. Patients with advanced tumour size scored significantly lower (median 5.5 of 9 possible points) when compared with those having tumours of a limited size (median 9 of 9 possible points; P=0.005). The median score of patients with T3/T4 tumours suggested the need for comprehensive neuropsychological evaluations for dementia. In conclusion, this study has demonstrated the correlation of reduced cognitive functioning in patients with advanced OSCC. As a consequence, instructions for the identification of early signs and of symptoms of oral cancer are strongly recommended for relatives and nursing staff of patients with cognitive impairment. Such patients might need immediate treatment for oral cancer but might not be able to understand the significance of their symptoms and therefore present late, often too late.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Carcinoma, Squamous Cell
KW - Dementia
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Mouth Neoplasms
KW - Neoplasm Staging
KW - Neuropsychological Tests
KW - Risk Factors
KW - Sensitivity and Specificity
U2 - 10.1016/j.oraloncology.2011.08.011
DO - 10.1016/j.oraloncology.2011.08.011
M3 - SCORING: Journal article
C2 - 21903447
VL - 47
SP - 993
EP - 997
JO - ORAL ONCOL
JF - ORAL ONCOL
SN - 1368-8375
IS - 10
ER -
