D-dimer levels for risk stratification in patients with suspected covid-19 - a prospective observational study
Abstract
Background: Elevated D-dimer levels have been observed in COVID-19 and are of prognostic value, but have not been compared to an appropriate control group. Methods: Observational cohort study including emergency patients with suspected or confirmed COVID-19. Logistic regression defined the association of D-dimer levels, COVID-19 positivity, age, and gender with 30-day-mortality. Results: 953 consecutive patients (median age 58, 43% women) presented with suspected COVID-19: 12 (7.4%) patients with confirmed SARS-CoV-2-infection died, compared with 28 (3.5%) patients without SARS-CoV-2-infection. Overall, most (56%) patients had elevated D-dimer levels (≥0.5mg/l). Age (OR 1.07, CI 1.05-1.10), D-dimer levels ≥0.5mg/l (OR 2.44, CI 0.98-7.39), and COVID-19 (OR 2.79, CI 1.28-5.80) were associated with 30-day-mortality. Conclusion: D-dimer levels are effective prognosticators in both patient groups.
Bibliografische Daten
Originalsprache | Englisch |
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ISSN | 1747-4884 |
DOIs | |
Status | Veröffentlicht - 2021 |
Extern publiziert | Ja |
Anmerkungen des Dekanats
Funding Information:
RT reports research support from the Swiss National Science Foundation (Grant No P300PB_167803), the Swiss Heart Foundation, the Swiss Society of Cardiology, the Cardiovascular Research Foundation
Funding Information:
Basel, the University of Basel and the University Hospital Basel and a Research Grant from Roche Diagnostics; JK is founder and major shareholder of Tapa Healthcare DAC, a start-up medical software company. The other authors have nothing to declare.
Funding Information:
The COVIVA study was financially supported by the Swiss Heart Foundation, the Scientific Funds of the Emergency Department, and the Cardiovascular Research Foundation Basel.
Publisher Copyright:
© 2021 Rila Publications Ltd.