Cytokine concentrations and regulatory T cells in living donor and deceased donor liver transplant recipients
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Cytokine concentrations and regulatory T cells in living donor and deceased donor liver transplant recipients. / Briem-Richter, Andrea; Leuschner, Alexander; Haag, Friedrich; Grabhorn, Enke; Ganschow, Rainer.
in: PEDIATR TRANSPLANT, Jahrgang 17, Nr. 2, 01.03.2013, S. 185-90.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - Cytokine concentrations and regulatory T cells in living donor and deceased donor liver transplant recipients
AU - Briem-Richter, Andrea
AU - Leuschner, Alexander
AU - Haag, Friedrich
AU - Grabhorn, Enke
AU - Ganschow, Rainer
N1 - © 2013 John Wiley & Sons A/S.
PY - 2013/3/1
Y1 - 2013/3/1
N2 - Outcomes of pediatric liver transplantation have constantly improved in the last decade. Living-related liver transplantation does not seem to improve long-term outcomes following liver transplantation, but few studies have evaluated immunological parameters of the alloimmune response after living vs. deceased donor organ transplantation. We analyzed numbers of regulatory T cells, lymphocyte subsets, and serum cytokine concentrations in 12 pediatric recipients of living-related liver transplants and in 28 pediatric recipients of deceased donor organs during their annual follow-ups. Transplant recipients who underwent living donor organ transplantation had significantly higher numbers of regulatory T cells and IL-4 serum concentrations than recipients of deceased donor organs; both of these factors are associated with beneficial outcomes and transplantation tolerance. Living-related liver transplantation may have potentially beneficial immunological aspects, although long-term outcomes do not seem to be better in recipients of living donor organs than in recipients of deceased donor organs. Further studies are needed to compare immunological aspects of the two transplant procedures.
AB - Outcomes of pediatric liver transplantation have constantly improved in the last decade. Living-related liver transplantation does not seem to improve long-term outcomes following liver transplantation, but few studies have evaluated immunological parameters of the alloimmune response after living vs. deceased donor organ transplantation. We analyzed numbers of regulatory T cells, lymphocyte subsets, and serum cytokine concentrations in 12 pediatric recipients of living-related liver transplants and in 28 pediatric recipients of deceased donor organs during their annual follow-ups. Transplant recipients who underwent living donor organ transplantation had significantly higher numbers of regulatory T cells and IL-4 serum concentrations than recipients of deceased donor organs; both of these factors are associated with beneficial outcomes and transplantation tolerance. Living-related liver transplantation may have potentially beneficial immunological aspects, although long-term outcomes do not seem to be better in recipients of living donor organs than in recipients of deceased donor organs. Further studies are needed to compare immunological aspects of the two transplant procedures.
KW - Adolescent
KW - Adult
KW - Biological Markers
KW - CD4 Lymphocyte Count
KW - Child
KW - Child, Preschool
KW - Cytokines
KW - Female
KW - Flow Cytometry
KW - Follow-Up Studies
KW - Humans
KW - Interleukin-4
KW - Liver Diseases
KW - Liver Transplantation
KW - Living Donors
KW - Male
KW - T-Lymphocytes, Regulatory
KW - Treatment Outcome
KW - Young Adult
U2 - 10.1111/petr.12044
DO - 10.1111/petr.12044
M3 - SCORING: Journal article
C2 - 23331338
VL - 17
SP - 185
EP - 190
JO - PEDIATR TRANSPLANT
JF - PEDIATR TRANSPLANT
SN - 1397-3142
IS - 2
ER -
