COVID-19-Associated Pulmonary Aspergillosis, March-August 2020
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COVID-19-Associated Pulmonary Aspergillosis, March-August 2020. / Salmanton-García, Jon; Sprute, Rosanne; Stemler, Jannik; Bartoletti, Michele; Dupont, Damien; Valerio, Maricela; García-Vidal, Carolina; Falces-Romero, Iker; Machado, Marina; de la Villa, Sofía; Schroeder, Maria; Hoyo, Irma; Hanses, Frank; Ferreira-Paim, Kennio; Giacobbe, Daniele Roberto; Meis, Jacques F; Gangneux, Jean-Pierre; Rodríguez-Guardado, Azucena; Antinori, Spinello; Sal, Ertan; Malaj, Xhorxha; Seidel, Danila; Cornely, Oliver A; Koehler, Philipp; FungiScope European Confederation of Medical Mycology/The International Society for Human and Animal Mycology Working Group2.
in: EMERG INFECT DIS, Jahrgang 27, Nr. 4, 2021, S. 1077-1086.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - COVID-19-Associated Pulmonary Aspergillosis, March-August 2020
AU - Salmanton-García, Jon
AU - Sprute, Rosanne
AU - Stemler, Jannik
AU - Bartoletti, Michele
AU - Dupont, Damien
AU - Valerio, Maricela
AU - García-Vidal, Carolina
AU - Falces-Romero, Iker
AU - Machado, Marina
AU - de la Villa, Sofía
AU - Schroeder, Maria
AU - Hoyo, Irma
AU - Hanses, Frank
AU - Ferreira-Paim, Kennio
AU - Giacobbe, Daniele Roberto
AU - Meis, Jacques F
AU - Gangneux, Jean-Pierre
AU - Rodríguez-Guardado, Azucena
AU - Antinori, Spinello
AU - Sal, Ertan
AU - Malaj, Xhorxha
AU - Seidel, Danila
AU - Cornely, Oliver A
AU - Koehler, Philipp
AU - FungiScope European Confederation of Medical Mycology/The International Society for Human and Animal Mycology Working Group2
PY - 2021
Y1 - 2021
N2 - Pneumonia caused by severe acute respiratory syndrome coronavirus 2 emerged in China at the end of 2019. Because of the severe immunomodulation and lymphocyte depletion caused by this virus and the subsequent administration of drugs directed at the immune system, we anticipated that patients might experience fungal superinfection. We collected data from 186 patients who had coronavirus disease-associated pulmonary aspergillosis (CAPA) worldwide during March-August 2020. Overall, 182 patients were admitted to the intensive care unit (ICU), including 180 with acute respiratory distress syndrome and 175 who received mechanical ventilation. CAPA was diagnosed a median of 10 days after coronavirus disease diagnosis. Aspergillus fumigatus was identified in 80.3% of patient cultures, 4 of which were azole-resistant. Most (52.7%) patients received voriconazole. In total, 52.2% of patients died; of the deaths, 33.0% were attributed to CAPA. We found that the cumulative incidence of CAPA in the ICU ranged from 1.0% to 39.1%.
AB - Pneumonia caused by severe acute respiratory syndrome coronavirus 2 emerged in China at the end of 2019. Because of the severe immunomodulation and lymphocyte depletion caused by this virus and the subsequent administration of drugs directed at the immune system, we anticipated that patients might experience fungal superinfection. We collected data from 186 patients who had coronavirus disease-associated pulmonary aspergillosis (CAPA) worldwide during March-August 2020. Overall, 182 patients were admitted to the intensive care unit (ICU), including 180 with acute respiratory distress syndrome and 175 who received mechanical ventilation. CAPA was diagnosed a median of 10 days after coronavirus disease diagnosis. Aspergillus fumigatus was identified in 80.3% of patient cultures, 4 of which were azole-resistant. Most (52.7%) patients received voriconazole. In total, 52.2% of patients died; of the deaths, 33.0% were attributed to CAPA. We found that the cumulative incidence of CAPA in the ICU ranged from 1.0% to 39.1%.
U2 - 10.3201/eid2704.204895
DO - 10.3201/eid2704.204895
M3 - SCORING: Journal article
C2 - 33539721
VL - 27
SP - 1077
EP - 1086
JO - EMERG INFECT DIS
JF - EMERG INFECT DIS
SN - 1080-6040
IS - 4
ER -
