Common breast cancer susceptibility loci are associated with triple-negative breast cancer.
Standard
Common breast cancer susceptibility loci are associated with triple-negative breast cancer. / Stevens, Kristen N; Vachon, Celine M; Lee, Adam M; Slager, Susan; Lesnick, Timothy; Olswold, Curtis; Fasching, Peter A; Miron, Penelope; Eccles, Diana; Carpenter, Jane E; Godwin, Andrew K; Ambrosone, Christine; Winqvist, Robert; Brauch, Hiltrud; Consortium, GENICA; Schmidt, Marjanka K; Cox, Angela; Cross, Simon S; Sawyer, Elinor; Hartmann, Arndt; Beckmann, Matthias W; Schulz-Wendtland, Rüdiger; Ekici, Arif B; Tapper, William J; Gerty, Susan M; Durcan, Lorraine; Graham, Nikki; Hein, Rebecca; Nickels, Stephan; Flesch-Janys, Dieter; Heinz, Judith; Sinn, Hans-Peter; Konstantopoulou, Irene; Fostira, Florentia; Pectasides, Dimitrios; Dimopoulos, Athanasios M; Fountzilas, George; Clarke, Christine L; Balleine, Rosemary; Olson, Janet E; Fredericksen, Zachary; Diasio, Robert B; Pathak, Harsh; Ross, Eric; Weaver, JoEllen; Rüdiger, Thomas; Försti, Asta; Dünnebier, Thomas; Ademuyiwa, Foluso; Kulkarni, Swati; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Ko, Yon-Dschun; Erik, Van Limbergen; Janssen, Hilde; Peto, Julian; Fletcher, Olivia; Giles, Graham G; Baglietto, Laura; Verhoef, Senno; Tomlinson, Ian; Kosma, Veli-Matti; Beesley, Jonathan; Greco, Dario; Blomqvist, Carl; Irwanto, Astrid; Liu, Jianjun; Blows, Fiona M; Dawson, Sarah-Jane; Margolin, Sara; Mannermaa, Arto; Martin, Nicholas G; Montgomery, Grant W; Lambrechts, Diether; Isabel, Dos Santos Silva; Severi, Gianluca; Hamann, Ute; Pharoah, Paul; Easton, Douglas F; Chang-Claude, Jenny; Yannoukakos, Drakoulis; Nevanlinna, Heli; Wang, Xianshu; Couch, Fergus J.
in: CANCER RES, Jahrgang 71, Nr. 19, 19, 2011, S. 6240-6249.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Common breast cancer susceptibility loci are associated with triple-negative breast cancer.
AU - Stevens, Kristen N
AU - Vachon, Celine M
AU - Lee, Adam M
AU - Slager, Susan
AU - Lesnick, Timothy
AU - Olswold, Curtis
AU - Fasching, Peter A
AU - Miron, Penelope
AU - Eccles, Diana
AU - Carpenter, Jane E
AU - Godwin, Andrew K
AU - Ambrosone, Christine
AU - Winqvist, Robert
AU - Brauch, Hiltrud
AU - Consortium, GENICA
AU - Schmidt, Marjanka K
AU - Cox, Angela
AU - Cross, Simon S
AU - Sawyer, Elinor
AU - Hartmann, Arndt
AU - Beckmann, Matthias W
AU - Schulz-Wendtland, Rüdiger
AU - Ekici, Arif B
AU - Tapper, William J
AU - Gerty, Susan M
AU - Durcan, Lorraine
AU - Graham, Nikki
AU - Hein, Rebecca
AU - Nickels, Stephan
AU - Flesch-Janys, Dieter
AU - Heinz, Judith
AU - Sinn, Hans-Peter
AU - Konstantopoulou, Irene
AU - Fostira, Florentia
AU - Pectasides, Dimitrios
AU - Dimopoulos, Athanasios M
AU - Fountzilas, George
AU - Clarke, Christine L
AU - Balleine, Rosemary
AU - Olson, Janet E
AU - Fredericksen, Zachary
AU - Diasio, Robert B
AU - Pathak, Harsh
AU - Ross, Eric
AU - Weaver, JoEllen
AU - Rüdiger, Thomas
AU - Försti, Asta
AU - Dünnebier, Thomas
AU - Ademuyiwa, Foluso
AU - Kulkarni, Swati
AU - Pylkäs, Katri
AU - Jukkola-Vuorinen, Arja
AU - Ko, Yon-Dschun
AU - Erik, Van Limbergen
AU - Janssen, Hilde
AU - Peto, Julian
AU - Fletcher, Olivia
AU - Giles, Graham G
AU - Baglietto, Laura
AU - Verhoef, Senno
AU - Tomlinson, Ian
AU - Kosma, Veli-Matti
AU - Beesley, Jonathan
AU - Greco, Dario
AU - Blomqvist, Carl
AU - Irwanto, Astrid
AU - Liu, Jianjun
AU - Blows, Fiona M
AU - Dawson, Sarah-Jane
AU - Margolin, Sara
AU - Mannermaa, Arto
AU - Martin, Nicholas G
AU - Montgomery, Grant W
AU - Lambrechts, Diether
AU - Isabel, Dos Santos Silva
AU - Severi, Gianluca
AU - Hamann, Ute
AU - Pharoah, Paul
AU - Easton, Douglas F
AU - Chang-Claude, Jenny
AU - Yannoukakos, Drakoulis
AU - Nevanlinna, Heli
AU - Wang, Xianshu
AU - Couch, Fergus J
PY - 2011
Y1 - 2011
N2 - Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer.
AB - Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer.
KW - Adult
KW - Humans
KW - Aged
KW - Female
KW - Middle Aged
KW - Young Adult
KW - European Continental Ancestry Group
KW - Case-Control Studies
KW - Risk
KW - Genetic Predisposition to Disease
KW - Breast Neoplasms/etiology/genetics/metabolism
KW - Chromosomes, Human, Pair 19/genetics
KW - Polymorphism, Single Nucleotide
KW - Receptors, Estrogen/genetics/metabolism
KW - Receptors, Progesterone/genetics/metabolism
KW - Adult
KW - Humans
KW - Aged
KW - Female
KW - Middle Aged
KW - Young Adult
KW - European Continental Ancestry Group
KW - Case-Control Studies
KW - Risk
KW - Genetic Predisposition to Disease
KW - Breast Neoplasms/etiology/genetics/metabolism
KW - Chromosomes, Human, Pair 19/genetics
KW - Polymorphism, Single Nucleotide
KW - Receptors, Estrogen/genetics/metabolism
KW - Receptors, Progesterone/genetics/metabolism
M3 - SCORING: Journal article
VL - 71
SP - 6240
EP - 6249
JO - CANCER RES
JF - CANCER RES
SN - 0008-5472
IS - 19
M1 - 19
ER -