Characterisation of advanced glycation endproducts in saliva from patients with diabetes mellitus
Standard
Characterisation of advanced glycation endproducts in saliva from patients with diabetes mellitus. / Yoon, Min-Sung; Jankowski, Vera; Montag, Susanne; Zidek, Walter; Henning, Lars; Schlüter, Hartmut; Tepel, Martin; Jankowski, Joachim.
in: BIOCHEM BIOPH RES CO, Jahrgang 323, Nr. 2, 15.10.2004, S. 377-81.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
Harvard
APA
Vancouver
Bibtex
}
RIS
TY - JOUR
T1 - Characterisation of advanced glycation endproducts in saliva from patients with diabetes mellitus
AU - Yoon, Min-Sung
AU - Jankowski, Vera
AU - Montag, Susanne
AU - Zidek, Walter
AU - Henning, Lars
AU - Schlüter, Hartmut
AU - Tepel, Martin
AU - Jankowski, Joachim
N1 - Copyright 2004 Elsevier Inc.
PY - 2004/10/15
Y1 - 2004/10/15
N2 - Patients with diabetes mellitus are prone to develop increased advanced glycation endproducts causing local complications and increased overall morbidity and mortality. Nuclear magnetic resonance spectra were determined in saliva of 52 consecutive patients with diabetes mellitus and 47 age-matched healthy control subjects. Resonance spectra showed specific peaks at 2.3, 7.3, and 8.4 ppm in saliva from patients with diabetes mellitus. These peaks could be generated by incubation of saliva from healthy control subjects with hypochloric acid in vitro, indicating the presence of advanced glycation endproducts. The presence of advanced glycation endproducts in patients with diabetes mellitus was associated with approximal plaque index, indicating increased periodontal damage. The study indicates that increased advanced glycation endproducts are involved in the pathogenesis of diabetic complications.
AB - Patients with diabetes mellitus are prone to develop increased advanced glycation endproducts causing local complications and increased overall morbidity and mortality. Nuclear magnetic resonance spectra were determined in saliva of 52 consecutive patients with diabetes mellitus and 47 age-matched healthy control subjects. Resonance spectra showed specific peaks at 2.3, 7.3, and 8.4 ppm in saliva from patients with diabetes mellitus. These peaks could be generated by incubation of saliva from healthy control subjects with hypochloric acid in vitro, indicating the presence of advanced glycation endproducts. The presence of advanced glycation endproducts in patients with diabetes mellitus was associated with approximal plaque index, indicating increased periodontal damage. The study indicates that increased advanced glycation endproducts are involved in the pathogenesis of diabetic complications.
KW - Adult
KW - Biomarkers
KW - Diabetes Complications
KW - Diabetes Mellitus
KW - Female
KW - Glycation End Products, Advanced
KW - Humans
KW - Magnetic Resonance Spectroscopy
KW - Male
KW - Middle Aged
KW - Periodontitis
KW - Saliva
KW - Clinical Trial
KW - Controlled Clinical Trial
KW - Journal Article
U2 - 10.1016/j.bbrc.2004.08.118
DO - 10.1016/j.bbrc.2004.08.118
M3 - SCORING: Journal article
C2 - 15369762
VL - 323
SP - 377
EP - 381
JO - BIOCHEM BIOPH RES CO
JF - BIOCHEM BIOPH RES CO
SN - 0006-291X
IS - 2
ER -