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CHADS(2) and CHA(2)DS (2)-VASc score of patients with atrial fibrillation or flutter and newly detected left atrial thrombus

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CHADS(2) and CHA(2)DS (2)-VASc score of patients with atrial fibrillation or flutter and newly detected left atrial thrombus. / Wasmer, Kristina; Köbe, Julia; Dechering, Dirk; Milberg, Peter; Pott, Christian; Vogler, Julia; Stypmann, Jörg; Waltenberger, Johannes; Mönnig, Gerold; Breithardt, Günter; Eckardt, Lars.

in: CLIN RES CARDIOL, Jahrgang 102, Nr. 2, 02.2013, S. 139-144.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Wasmer, K, Köbe, J, Dechering, D, Milberg, P, Pott, C, Vogler, J, Stypmann, J, Waltenberger, J, Mönnig, G, Breithardt, G & Eckardt, L 2013, 'CHADS(2) and CHA(2)DS (2)-VASc score of patients with atrial fibrillation or flutter and newly detected left atrial thrombus', CLIN RES CARDIOL, Jg. 102, Nr. 2, S. 139-144. https://doi.org/10.1007/s00392-012-0507-4

APA

Wasmer, K., Köbe, J., Dechering, D., Milberg, P., Pott, C., Vogler, J., Stypmann, J., Waltenberger, J., Mönnig, G., Breithardt, G., & Eckardt, L. (2013). CHADS(2) and CHA(2)DS (2)-VASc score of patients with atrial fibrillation or flutter and newly detected left atrial thrombus. CLIN RES CARDIOL, 102(2), 139-144. https://doi.org/10.1007/s00392-012-0507-4

Vancouver

Wasmer K, Köbe J, Dechering D, Milberg P, Pott C, Vogler J et al. CHADS(2) and CHA(2)DS (2)-VASc score of patients with atrial fibrillation or flutter and newly detected left atrial thrombus. CLIN RES CARDIOL. 2013 Feb;102(2):139-144. https://doi.org/10.1007/s00392-012-0507-4

Bibtex

@article{bf264bc85f5848b7b0b4198e0ef90352,
title = "CHADS(2) and CHA(2)DS (2)-VASc score of patients with atrial fibrillation or flutter and newly detected left atrial thrombus",
abstract = "BACKGROUND: The risk of developing a stroke or systemic embolus due to a left atrial (LA) thrombus in patients with atrial fibrillation (AF) and/or atrial flutter (AFL) is estimated by the CHADS(2) score and more recently the CHA(2)DS(2)-VASc score. We aimed to further characterize AF/AFL patients who were found to have a LA thrombus on a transesophageal echocardiogram (TEE).METHODS AND RESULTS: Of 3,165 TEE between 2005 and 2011 for a broad spectrum of indications, we detected 65 AF patients with LA thrombus (2 %). There were 40 men and 25 women, mean age was 65 ± 13 years (range 36-88 years). Mean CHADS(2) score was 1.8 ± 1.1 and mean CHA(2)DS(2)-VASc score was 3.0 ± 1.6. 11 patients (17 %) had a CHADS(2) score of 0, 12 patients (18 %) of 1, 28 patients (43 %) of 2 and 12 patients (18 %) of 3. Hypertension was the most frequent risk factor (72 %), followed by congestive heart failure (32 %), diabetes (23 %) and age ≥75 years (23 %). Mean difference between CHADS(2) and CHA(2)DS(2)-VASc was 1.25 ± 0.91. Of the 11 patients (17 %) with a LA thrombus despite a CHADS(2) score of 0, five had a CHA(2)DS(2)-VASc score of 0, four a CHA(2)DS(2)-VASc score of 1 and two a CHA(2)DS(2)-VASc score of 2.CONCLUSION: In an unselected TEE population with newly detected LA thrombus about one-third of patients fell into the low-risk group when classified based on the CHADS(2) score, while a much lower population fell in the same low-risk group when classified according to the CHA(2)DS(2)-VASc score. However, this does not prove clinical superiority of the CHA(2)DS(2)-VASc score over the established CHADS(2) score. Whether our observation has clinical implications (e.g. TEE prior to LA ablation irrespective of CHADS(2) score), or argues for use of the CHA(2)DS(2)-VASc score needs to be evaluated in prospective studies.",
keywords = "Adult, Age Factors, Aged, Aged, 80 and over, Atrial Fibrillation/complications, Atrial Flutter/complications, Decision Support Techniques, Diabetes Complications/etiology, Echocardiography, Transesophageal, Embolism/etiology, Female, Heart Failure/complications, Humans, Hypertension/complications, Male, Middle Aged, Retrospective Studies, Risk Assessment, Risk Factors, Stroke/etiology, Thrombosis/diagnostic imaging",
author = "Kristina Wasmer and Julia K{\"o}be and Dirk Dechering and Peter Milberg and Christian Pott and Julia Vogler and J{\"o}rg Stypmann and Johannes Waltenberger and Gerold M{\"o}nnig and G{\"u}nter Breithardt and Lars Eckardt",
year = "2013",
month = feb,
doi = "10.1007/s00392-012-0507-4",
language = "English",
volume = "102",
pages = "139--144",
journal = "CLIN RES CARDIOL",
issn = "1861-0684",
publisher = "D. Steinkopff-Verlag",
number = "2",

}

RIS

TY - JOUR

T1 - CHADS(2) and CHA(2)DS (2)-VASc score of patients with atrial fibrillation or flutter and newly detected left atrial thrombus

AU - Wasmer, Kristina

AU - Köbe, Julia

AU - Dechering, Dirk

AU - Milberg, Peter

AU - Pott, Christian

AU - Vogler, Julia

AU - Stypmann, Jörg

AU - Waltenberger, Johannes

AU - Mönnig, Gerold

AU - Breithardt, Günter

AU - Eckardt, Lars

PY - 2013/2

Y1 - 2013/2

N2 - BACKGROUND: The risk of developing a stroke or systemic embolus due to a left atrial (LA) thrombus in patients with atrial fibrillation (AF) and/or atrial flutter (AFL) is estimated by the CHADS(2) score and more recently the CHA(2)DS(2)-VASc score. We aimed to further characterize AF/AFL patients who were found to have a LA thrombus on a transesophageal echocardiogram (TEE).METHODS AND RESULTS: Of 3,165 TEE between 2005 and 2011 for a broad spectrum of indications, we detected 65 AF patients with LA thrombus (2 %). There were 40 men and 25 women, mean age was 65 ± 13 years (range 36-88 years). Mean CHADS(2) score was 1.8 ± 1.1 and mean CHA(2)DS(2)-VASc score was 3.0 ± 1.6. 11 patients (17 %) had a CHADS(2) score of 0, 12 patients (18 %) of 1, 28 patients (43 %) of 2 and 12 patients (18 %) of 3. Hypertension was the most frequent risk factor (72 %), followed by congestive heart failure (32 %), diabetes (23 %) and age ≥75 years (23 %). Mean difference between CHADS(2) and CHA(2)DS(2)-VASc was 1.25 ± 0.91. Of the 11 patients (17 %) with a LA thrombus despite a CHADS(2) score of 0, five had a CHA(2)DS(2)-VASc score of 0, four a CHA(2)DS(2)-VASc score of 1 and two a CHA(2)DS(2)-VASc score of 2.CONCLUSION: In an unselected TEE population with newly detected LA thrombus about one-third of patients fell into the low-risk group when classified based on the CHADS(2) score, while a much lower population fell in the same low-risk group when classified according to the CHA(2)DS(2)-VASc score. However, this does not prove clinical superiority of the CHA(2)DS(2)-VASc score over the established CHADS(2) score. Whether our observation has clinical implications (e.g. TEE prior to LA ablation irrespective of CHADS(2) score), or argues for use of the CHA(2)DS(2)-VASc score needs to be evaluated in prospective studies.

AB - BACKGROUND: The risk of developing a stroke or systemic embolus due to a left atrial (LA) thrombus in patients with atrial fibrillation (AF) and/or atrial flutter (AFL) is estimated by the CHADS(2) score and more recently the CHA(2)DS(2)-VASc score. We aimed to further characterize AF/AFL patients who were found to have a LA thrombus on a transesophageal echocardiogram (TEE).METHODS AND RESULTS: Of 3,165 TEE between 2005 and 2011 for a broad spectrum of indications, we detected 65 AF patients with LA thrombus (2 %). There were 40 men and 25 women, mean age was 65 ± 13 years (range 36-88 years). Mean CHADS(2) score was 1.8 ± 1.1 and mean CHA(2)DS(2)-VASc score was 3.0 ± 1.6. 11 patients (17 %) had a CHADS(2) score of 0, 12 patients (18 %) of 1, 28 patients (43 %) of 2 and 12 patients (18 %) of 3. Hypertension was the most frequent risk factor (72 %), followed by congestive heart failure (32 %), diabetes (23 %) and age ≥75 years (23 %). Mean difference between CHADS(2) and CHA(2)DS(2)-VASc was 1.25 ± 0.91. Of the 11 patients (17 %) with a LA thrombus despite a CHADS(2) score of 0, five had a CHA(2)DS(2)-VASc score of 0, four a CHA(2)DS(2)-VASc score of 1 and two a CHA(2)DS(2)-VASc score of 2.CONCLUSION: In an unselected TEE population with newly detected LA thrombus about one-third of patients fell into the low-risk group when classified based on the CHADS(2) score, while a much lower population fell in the same low-risk group when classified according to the CHA(2)DS(2)-VASc score. However, this does not prove clinical superiority of the CHA(2)DS(2)-VASc score over the established CHADS(2) score. Whether our observation has clinical implications (e.g. TEE prior to LA ablation irrespective of CHADS(2) score), or argues for use of the CHA(2)DS(2)-VASc score needs to be evaluated in prospective studies.

KW - Adult

KW - Age Factors

KW - Aged

KW - Aged, 80 and over

KW - Atrial Fibrillation/complications

KW - Atrial Flutter/complications

KW - Decision Support Techniques

KW - Diabetes Complications/etiology

KW - Echocardiography, Transesophageal

KW - Embolism/etiology

KW - Female

KW - Heart Failure/complications

KW - Humans

KW - Hypertension/complications

KW - Male

KW - Middle Aged

KW - Retrospective Studies

KW - Risk Assessment

KW - Risk Factors

KW - Stroke/etiology

KW - Thrombosis/diagnostic imaging

U2 - 10.1007/s00392-012-0507-4

DO - 10.1007/s00392-012-0507-4

M3 - SCORING: Journal article

C2 - 22983022

VL - 102

SP - 139

EP - 144

JO - CLIN RES CARDIOL

JF - CLIN RES CARDIOL

SN - 1861-0684

IS - 2

ER -