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Cerebral signal intensity abnormalities on T2-weighted MR images in HIV patients with highly active antiretroviral therapy: relationship with clinical parameters and interval changes

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Cerebral signal intensity abnormalities on T2-weighted MR images in HIV patients with highly active antiretroviral therapy: relationship with clinical parameters and interval changes. / Hanning, Uta; Husstedt, Ingo W; Niederstadt, Thomas-Ulrich; Evers, Stefan; Heindel, Walter; Kloska, Stephan P.

in: ACAD RADIOL, Jahrgang 18, Nr. 9, 09.2011, S. 1144-50.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Hanning, U, Husstedt, IW, Niederstadt, T-U, Evers, S, Heindel, W & Kloska, SP 2011, 'Cerebral signal intensity abnormalities on T2-weighted MR images in HIV patients with highly active antiretroviral therapy: relationship with clinical parameters and interval changes', ACAD RADIOL, Jg. 18, Nr. 9, S. 1144-50. https://doi.org/10.1016/j.acra.2011.04.013

APA

Hanning, U., Husstedt, I. W., Niederstadt, T-U., Evers, S., Heindel, W., & Kloska, S. P. (2011). Cerebral signal intensity abnormalities on T2-weighted MR images in HIV patients with highly active antiretroviral therapy: relationship with clinical parameters and interval changes. ACAD RADIOL, 18(9), 1144-50. https://doi.org/10.1016/j.acra.2011.04.013

Vancouver

Hanning U, Husstedt IW, Niederstadt T-U, Evers S, Heindel W, Kloska SP. Cerebral signal intensity abnormalities on T2-weighted MR images in HIV patients with highly active antiretroviral therapy: relationship with clinical parameters and interval changes. ACAD RADIOL. 2011 Sep;18(9):1144-50. https://doi.org/10.1016/j.acra.2011.04.013

Bibtex

@article{c1196c803aef4f87abbf97d6172735af,
title = "Cerebral signal intensity abnormalities on T2-weighted MR images in HIV patients with highly active antiretroviral therapy: relationship with clinical parameters and interval changes",
abstract = "RATIONALE AND OBJECTIVES: The aim of this study was to assess the relationship between immune state and cerebral signal intensity abnormalities (SIAs) on T2-weighted magnetic resonance images in subjects with human immunodeficiency virus type 1 infection and highly active antiretroviral therapy.MATERIALS AND METHODS: Thirty-two subjects underwent a total of 109 magnetic resonance studies. The presence of human immunodeficiency virus-associated neurocognitive disorder, categorized CD4(+) T lymphocyte count, and plasma viral load were assessed for relationship with the severity and interval change of SIAs for different anatomic locations of the brain.RESULTS: Subjects with multifocal patterns of SIAs had CD4(+) cell counts < 200 cells/μL in 66.0%, whereas subjects with diffuse patterns of SIAs had CD4(+) cell counts < 200 cells/μL in only 31.4% (P < .001). Subjects without SIAs in the basal ganglia had CD4(+) cell counts < 200 cells/μL in 37.0%, whereas subjects with minor and moderate SIAs in the basal ganglia had CD4(+) cell counts < 200 cells/μL in 78.3% and 80.0%, respectively (P < .005). The percentage of subjects with CD4(+) cell counts < 200 cells/μL was 85.7% when there were progressive periventricular SIA changes and 45.5% when periventricular SIA changes were stable in follow-up (P < .05).CONCLUSIONS: The presence and progression of cerebral SIAs on T2-weighted magnetic resonance images reflecting cerebral infection with human immunodeficiency virus are significantly related to impaired immune state as measured by CD4(+) cell count.",
keywords = "AIDS Dementia Complex, Antiretroviral Therapy, Highly Active, CD4 Lymphocyte Count, Chi-Square Distribution, Disease Progression, Female, HIV-1, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Retrospective Studies, Viral Load, Journal Article",
author = "Uta Hanning and Husstedt, {Ingo W} and Thomas-Ulrich Niederstadt and Stefan Evers and Walter Heindel and Kloska, {Stephan P}",
note = "Copyright {\textcopyright} 2011 AUR. Published by Elsevier Inc. All rights reserved.",
year = "2011",
month = sep,
doi = "10.1016/j.acra.2011.04.013",
language = "English",
volume = "18",
pages = "1144--50",
journal = "ACAD RADIOL",
issn = "1076-6332",
publisher = "Elsevier USA",
number = "9",

}

RIS

TY - JOUR

T1 - Cerebral signal intensity abnormalities on T2-weighted MR images in HIV patients with highly active antiretroviral therapy: relationship with clinical parameters and interval changes

AU - Hanning, Uta

AU - Husstedt, Ingo W

AU - Niederstadt, Thomas-Ulrich

AU - Evers, Stefan

AU - Heindel, Walter

AU - Kloska, Stephan P

N1 - Copyright © 2011 AUR. Published by Elsevier Inc. All rights reserved.

PY - 2011/9

Y1 - 2011/9

N2 - RATIONALE AND OBJECTIVES: The aim of this study was to assess the relationship between immune state and cerebral signal intensity abnormalities (SIAs) on T2-weighted magnetic resonance images in subjects with human immunodeficiency virus type 1 infection and highly active antiretroviral therapy.MATERIALS AND METHODS: Thirty-two subjects underwent a total of 109 magnetic resonance studies. The presence of human immunodeficiency virus-associated neurocognitive disorder, categorized CD4(+) T lymphocyte count, and plasma viral load were assessed for relationship with the severity and interval change of SIAs for different anatomic locations of the brain.RESULTS: Subjects with multifocal patterns of SIAs had CD4(+) cell counts < 200 cells/μL in 66.0%, whereas subjects with diffuse patterns of SIAs had CD4(+) cell counts < 200 cells/μL in only 31.4% (P < .001). Subjects without SIAs in the basal ganglia had CD4(+) cell counts < 200 cells/μL in 37.0%, whereas subjects with minor and moderate SIAs in the basal ganglia had CD4(+) cell counts < 200 cells/μL in 78.3% and 80.0%, respectively (P < .005). The percentage of subjects with CD4(+) cell counts < 200 cells/μL was 85.7% when there were progressive periventricular SIA changes and 45.5% when periventricular SIA changes were stable in follow-up (P < .05).CONCLUSIONS: The presence and progression of cerebral SIAs on T2-weighted magnetic resonance images reflecting cerebral infection with human immunodeficiency virus are significantly related to impaired immune state as measured by CD4(+) cell count.

AB - RATIONALE AND OBJECTIVES: The aim of this study was to assess the relationship between immune state and cerebral signal intensity abnormalities (SIAs) on T2-weighted magnetic resonance images in subjects with human immunodeficiency virus type 1 infection and highly active antiretroviral therapy.MATERIALS AND METHODS: Thirty-two subjects underwent a total of 109 magnetic resonance studies. The presence of human immunodeficiency virus-associated neurocognitive disorder, categorized CD4(+) T lymphocyte count, and plasma viral load were assessed for relationship with the severity and interval change of SIAs for different anatomic locations of the brain.RESULTS: Subjects with multifocal patterns of SIAs had CD4(+) cell counts < 200 cells/μL in 66.0%, whereas subjects with diffuse patterns of SIAs had CD4(+) cell counts < 200 cells/μL in only 31.4% (P < .001). Subjects without SIAs in the basal ganglia had CD4(+) cell counts < 200 cells/μL in 37.0%, whereas subjects with minor and moderate SIAs in the basal ganglia had CD4(+) cell counts < 200 cells/μL in 78.3% and 80.0%, respectively (P < .005). The percentage of subjects with CD4(+) cell counts < 200 cells/μL was 85.7% when there were progressive periventricular SIA changes and 45.5% when periventricular SIA changes were stable in follow-up (P < .05).CONCLUSIONS: The presence and progression of cerebral SIAs on T2-weighted magnetic resonance images reflecting cerebral infection with human immunodeficiency virus are significantly related to impaired immune state as measured by CD4(+) cell count.

KW - AIDS Dementia Complex

KW - Antiretroviral Therapy, Highly Active

KW - CD4 Lymphocyte Count

KW - Chi-Square Distribution

KW - Disease Progression

KW - Female

KW - HIV-1

KW - Humans

KW - Image Interpretation, Computer-Assisted

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Retrospective Studies

KW - Viral Load

KW - Journal Article

U2 - 10.1016/j.acra.2011.04.013

DO - 10.1016/j.acra.2011.04.013

M3 - SCORING: Journal article

C2 - 21703882

VL - 18

SP - 1144

EP - 1150

JO - ACAD RADIOL

JF - ACAD RADIOL

SN - 1076-6332

IS - 9

ER -