Cerebral microdialysis in acutely brain-injured patients with spreading depolarizations
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Cerebral microdialysis in acutely brain-injured patients with spreading depolarizations. / Krajewski, K L; Orakcioglu, B; Haux, D; Hertle, D N; Santos, E; Kiening, K L; Unterberg, A W; Sakowitz, O W.
in: ACTA NEUROCHIR SUPPL, Jahrgang 110, Nr. Pt 1, 2011, S. 125-30.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Cerebral microdialysis in acutely brain-injured patients with spreading depolarizations
AU - Krajewski, K L
AU - Orakcioglu, B
AU - Haux, D
AU - Hertle, D N
AU - Santos, E
AU - Kiening, K L
AU - Unterberg, A W
AU - Sakowitz, O W
PY - 2011
Y1 - 2011
N2 - Multimodal cerebral monitoring was utilized to examine the relationship between pathological changes in microdialysis parameters and the occurrence of spreading depolarizations (SD) in brain-injured patients. SD are a relatively newly discovered phenomenon in man found to be linked to secondary insults and infarct growth and they can be detected via electrocorticography (ECoG). A total of 24 brain-injured patients (mean age: 52±11 years) requiring craniotomy took part in this prospective observational study. Each patient was monitored with a linear strip electrode for ECoG data and a cerebral microdialysis probe. SD were detected in 13 of the 24 patients. Pathological concentrations of glucose and lactate in brain parenchyma were significantly correlated with various time points prior to and/or immediately following the SD. Severe systemic hyperglycemia and systemic hypoglycemia were also found to be correlated with the occurrence of SD. The present study shows a clear relationship between SD and pathological changes in cerebral metabolism; further studies are needed to elucidate these complex interactions with the ultimate goal of developing therapeutic strategies for improving outcome in brain-injured patients.
AB - Multimodal cerebral monitoring was utilized to examine the relationship between pathological changes in microdialysis parameters and the occurrence of spreading depolarizations (SD) in brain-injured patients. SD are a relatively newly discovered phenomenon in man found to be linked to secondary insults and infarct growth and they can be detected via electrocorticography (ECoG). A total of 24 brain-injured patients (mean age: 52±11 years) requiring craniotomy took part in this prospective observational study. Each patient was monitored with a linear strip electrode for ECoG data and a cerebral microdialysis probe. SD were detected in 13 of the 24 patients. Pathological concentrations of glucose and lactate in brain parenchyma were significantly correlated with various time points prior to and/or immediately following the SD. Severe systemic hyperglycemia and systemic hypoglycemia were also found to be correlated with the occurrence of SD. The present study shows a clear relationship between SD and pathological changes in cerebral metabolism; further studies are needed to elucidate these complex interactions with the ultimate goal of developing therapeutic strategies for improving outcome in brain-injured patients.
KW - Adult
KW - Brain Injuries
KW - Cerebral Cortex
KW - Cortical Spreading Depression
KW - Electroencephalography
KW - Female
KW - Glucose
KW - Humans
KW - Lactic Acid
KW - Male
KW - Microdialysis
KW - Middle Aged
KW - Prospective Studies
KW - Severity of Illness Index
KW - Statistics as Topic
KW - Time Factors
U2 - 10.1007/978-3-7091-0353-1_22
DO - 10.1007/978-3-7091-0353-1_22
M3 - SCORING: Journal article
C2 - 21116927
VL - 110
SP - 125
EP - 130
JO - ACTA NEUROCHIR SUPPL
JF - ACTA NEUROCHIR SUPPL
SN - 0065-1419
IS - Pt 1
ER -
