Catheter ablation of atrial fibrillation in the young: insights from the German Ablation Registry
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Catheter ablation of atrial fibrillation in the young: insights from the German Ablation Registry. / Chun, K R Julian; Schmidt, Boris; Kuck, Karl-Heinz; Andresen, Dietrich; Willems, Stefan; Spitzer, Stefan G; Hoffmann, Ellen; Schumacher, Burghard; Eckardt, Lars; Seidl, Karlheinz; Jünger, Claus; Horack, Martin; Brachmann, Johannes; Senges, Jochen.
in: CLIN RES CARDIOL, Jahrgang 102, Nr. 6, 06.2013, S. 459-468.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - Catheter ablation of atrial fibrillation in the young: insights from the German Ablation Registry
AU - Chun, K R Julian
AU - Schmidt, Boris
AU - Kuck, Karl-Heinz
AU - Andresen, Dietrich
AU - Willems, Stefan
AU - Spitzer, Stefan G
AU - Hoffmann, Ellen
AU - Schumacher, Burghard
AU - Eckardt, Lars
AU - Seidl, Karlheinz
AU - Jünger, Claus
AU - Horack, Martin
AU - Brachmann, Johannes
AU - Senges, Jochen
PY - 2013/6
Y1 - 2013/6
N2 - INTRODUCTION: Catheter ablation of paroxysmal atrial fibrillation (PAF) has been suggested as first-line treatment for selected patients (pts). However, patient characteristics, procedural data, and complication rate in the group of young patients remain undetermined.METHODS: The German Ablation Registry has been designed as a multi-center prospective registry. AF ablation data were collected from 51 German centers between March 2007 to September 2012 and 2 groups were defined (group A: ≤45 years, group B: >45 years). Data were analyzed according to patient characteristics, procedural data, and complications. To calculate differences between both groups CHI2 or Mann-Whitney-Wilcoxon tests was utilized.RESULTS: A total of 7243 patients undergoing AF ablation were included (group A: 593, 8.2 %; group B: 6650, 91.8 %). Male gender and PAF were significantly more often present in group A. Patient characteristic revealed decreased co-morbidities in the young. In both groups circumferential pulmonary vein isolation represented the procedural cornerstone, whereas substrate modification was significantly more often performed in group B. Procedure-, and fluoroscopy-time was similar but there was a shorter hospital stay and a favorable complication profile in the young. After 12 months AF recurrence and use of antiarrhythmic drugs were less common in group A.CONCLUSION: The young AF ablation patient has typically paroxysmal AF and less comorbidities. In this group, catheter ablation of AF is associated with a lower major complication rate, shorter hospitalization, and a favorable clinical outcome.
AB - INTRODUCTION: Catheter ablation of paroxysmal atrial fibrillation (PAF) has been suggested as first-line treatment for selected patients (pts). However, patient characteristics, procedural data, and complication rate in the group of young patients remain undetermined.METHODS: The German Ablation Registry has been designed as a multi-center prospective registry. AF ablation data were collected from 51 German centers between March 2007 to September 2012 and 2 groups were defined (group A: ≤45 years, group B: >45 years). Data were analyzed according to patient characteristics, procedural data, and complications. To calculate differences between both groups CHI2 or Mann-Whitney-Wilcoxon tests was utilized.RESULTS: A total of 7243 patients undergoing AF ablation were included (group A: 593, 8.2 %; group B: 6650, 91.8 %). Male gender and PAF were significantly more often present in group A. Patient characteristic revealed decreased co-morbidities in the young. In both groups circumferential pulmonary vein isolation represented the procedural cornerstone, whereas substrate modification was significantly more often performed in group B. Procedure-, and fluoroscopy-time was similar but there was a shorter hospital stay and a favorable complication profile in the young. After 12 months AF recurrence and use of antiarrhythmic drugs were less common in group A.CONCLUSION: The young AF ablation patient has typically paroxysmal AF and less comorbidities. In this group, catheter ablation of AF is associated with a lower major complication rate, shorter hospitalization, and a favorable clinical outcome.
KW - Adult
KW - Age Factors
KW - Aged
KW - Atrial Fibrillation/surgery
KW - Catheter Ablation/methods
KW - Female
KW - Fluoroscopy
KW - Follow-Up Studies
KW - Germany
KW - Hospitalization/statistics & numerical data
KW - Humans
KW - Length of Stay
KW - Male
KW - Middle Aged
KW - Prospective Studies
KW - Pulmonary Veins/surgery
KW - Recurrence
KW - Registries
KW - Sex Factors
KW - Statistics, Nonparametric
KW - Time Factors
KW - Treatment Outcome
U2 - 10.1007/s00392-013-0553-6
DO - 10.1007/s00392-013-0553-6
M3 - SCORING: Journal article
C2 - 23503755
VL - 102
SP - 459
EP - 468
JO - CLIN RES CARDIOL
JF - CLIN RES CARDIOL
SN - 1861-0684
IS - 6
ER -