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Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses

Standard

Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses. / Li, Shuo; Raychaudhuri, Sumana; Lee, Stephen Alexander; Brockmann, Marisa M.; Wang, Jing; Kusick, Grant; Prater, Christine; Syed, Sarah; Falahati, Hanieh; Ramos, Raul; Bartol, Tomas M.; Hosy, Eric; Watanabe, Shigeki.

in: NAT COMMUN, Jahrgang 12, Nr. 1, 29.01.2021, S. 677.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Li, S, Raychaudhuri, S, Lee, SA, Brockmann, MM, Wang, J, Kusick, G, Prater, C, Syed, S, Falahati, H, Ramos, R, Bartol, TM, Hosy, E & Watanabe, S 2021, 'Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses', NAT COMMUN, Jg. 12, Nr. 1, S. 677. https://doi.org/10.1038/s41467-021-21004-x

APA

Li, S., Raychaudhuri, S., Lee, S. A., Brockmann, M. M., Wang, J., Kusick, G., Prater, C., Syed, S., Falahati, H., Ramos, R., Bartol, T. M., Hosy, E., & Watanabe, S. (2021). Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses. NAT COMMUN, 12(1), 677. https://doi.org/10.1038/s41467-021-21004-x

Vancouver

Li S, Raychaudhuri S, Lee SA, Brockmann MM, Wang J, Kusick G et al. Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses. NAT COMMUN. 2021 Jan 29;12(1):677. https://doi.org/10.1038/s41467-021-21004-x

Bibtex

@article{7a3df28dfaa948c6b9ca6c69ba17d99f,
title = "Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses",
abstract = "Neurotransmitter is released synchronously and asynchronously following an action potential. Our recent study indicates that the release sites of these two phases are segregated within an active zone, with asynchronous release sites enriched near the center in mouse hippocampal synapses. Here we demonstrate that synchronous and asynchronous release sites are aligned with AMPA receptor and NMDA receptor clusters, respectively. Computational simulations indicate that this spatial and temporal arrangement of release can lead to maximal membrane depolarization through AMPA receptors, alleviating the pore-blocking magnesium leading to greater activation of NMDA receptors. Together, these results suggest that release sites are likely organized to activate NMDA receptors efficiently.",
author = "Shuo Li and Sumana Raychaudhuri and Lee, {Stephen Alexander} and Brockmann, {Marisa M.} and Jing Wang and Grant Kusick and Christine Prater and Sarah Syed and Hanieh Falahati and Raul Ramos and Bartol, {Tomas M.} and Eric Hosy and Shigeki Watanabe",
year = "2021",
month = jan,
day = "29",
doi = "10.1038/s41467-021-21004-x",
language = "English",
volume = "12",
pages = "677",
journal = "NAT COMMUN",
issn = "2041-1723",
publisher = "NATURE PUBLISHING GROUP",
number = "1",

}

RIS

TY - JOUR

T1 - Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses

AU - Li, Shuo

AU - Raychaudhuri, Sumana

AU - Lee, Stephen Alexander

AU - Brockmann, Marisa M.

AU - Wang, Jing

AU - Kusick, Grant

AU - Prater, Christine

AU - Syed, Sarah

AU - Falahati, Hanieh

AU - Ramos, Raul

AU - Bartol, Tomas M.

AU - Hosy, Eric

AU - Watanabe, Shigeki

PY - 2021/1/29

Y1 - 2021/1/29

N2 - Neurotransmitter is released synchronously and asynchronously following an action potential. Our recent study indicates that the release sites of these two phases are segregated within an active zone, with asynchronous release sites enriched near the center in mouse hippocampal synapses. Here we demonstrate that synchronous and asynchronous release sites are aligned with AMPA receptor and NMDA receptor clusters, respectively. Computational simulations indicate that this spatial and temporal arrangement of release can lead to maximal membrane depolarization through AMPA receptors, alleviating the pore-blocking magnesium leading to greater activation of NMDA receptors. Together, these results suggest that release sites are likely organized to activate NMDA receptors efficiently.

AB - Neurotransmitter is released synchronously and asynchronously following an action potential. Our recent study indicates that the release sites of these two phases are segregated within an active zone, with asynchronous release sites enriched near the center in mouse hippocampal synapses. Here we demonstrate that synchronous and asynchronous release sites are aligned with AMPA receptor and NMDA receptor clusters, respectively. Computational simulations indicate that this spatial and temporal arrangement of release can lead to maximal membrane depolarization through AMPA receptors, alleviating the pore-blocking magnesium leading to greater activation of NMDA receptors. Together, these results suggest that release sites are likely organized to activate NMDA receptors efficiently.

U2 - 10.1038/s41467-021-21004-x

DO - 10.1038/s41467-021-21004-x

M3 - SCORING: Journal article

VL - 12

SP - 677

JO - NAT COMMUN

JF - NAT COMMUN

SN - 2041-1723

IS - 1

ER -