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Association of N-acetylaspartate and cerebrospinal fluid Aβ42 in dementia.

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Association of N-acetylaspartate and cerebrospinal fluid Aβ42 in dementia. / Jessen, Frank; Lewczuk, Piotr; Gür, Okan; Block, Wolfgang; Ende, Gabriele; Frölich, Lutz; Hammen, Thilo; Arlt, Sönke; Kornhuber, Johannes; Kucinski, Thomas; Popp, Julius; Peters, Oliver; Maier, Wolfgang; Träber, Frank; Wiltfang, Jens.

in: J ALZHEIMERS DIS, Jahrgang 27, Nr. 2, 2, 2011, S. 393-399.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Jessen, F, Lewczuk, P, Gür, O, Block, W, Ende, G, Frölich, L, Hammen, T, Arlt, S, Kornhuber, J, Kucinski, T, Popp, J, Peters, O, Maier, W, Träber, F & Wiltfang, J 2011, 'Association of N-acetylaspartate and cerebrospinal fluid Aβ42 in dementia.', J ALZHEIMERS DIS, Jg. 27, Nr. 2, 2, S. 393-399. <http://www.ncbi.nlm.nih.gov/pubmed/21841259?dopt=Citation>

APA

Jessen, F., Lewczuk, P., Gür, O., Block, W., Ende, G., Frölich, L., Hammen, T., Arlt, S., Kornhuber, J., Kucinski, T., Popp, J., Peters, O., Maier, W., Träber, F., & Wiltfang, J. (2011). Association of N-acetylaspartate and cerebrospinal fluid Aβ42 in dementia. J ALZHEIMERS DIS, 27(2), 393-399. [2]. http://www.ncbi.nlm.nih.gov/pubmed/21841259?dopt=Citation

Vancouver

Jessen F, Lewczuk P, Gür O, Block W, Ende G, Frölich L et al. Association of N-acetylaspartate and cerebrospinal fluid Aβ42 in dementia. J ALZHEIMERS DIS. 2011;27(2):393-399. 2.

Bibtex

@article{89e11b809f114c6ba7aec06631cf2131,
title = "Association of N-acetylaspartate and cerebrospinal fluid Aβ42 in dementia.",
abstract = "The interplay of amyloid and mitochondrial function is considered crucial in the pathophysiology of Alzheimer's disease (AD). We tested the association of the putative marker of mitochondrial function N-acetylaspartate (NAA) as measured by proton magnetic resonance spectroscopy within the medial temporal lobe and cerebrospinal fluid amyoid-?42 (A?42), total Tau and pTau181. 109 patients were recruited in a multicenter study (40 mild AD patients, 14 non-AD dementia patients, 29 mild cognitive impairment (MCI) AD-type patients, 26 MCI of non-AD type patients). NAA correlated with A?42 within the AD group. Since the NAA concentration is coupled to neuronal mitochondrial function, the correlation between NAA and A?42 may reflect the interaction between disrupted mitochondrial pathways and amyloid production.",
author = "Frank Jessen and Piotr Lewczuk and Okan G{\"u}r and Wolfgang Block and Gabriele Ende and Lutz Fr{\"o}lich and Thilo Hammen and S{\"o}nke Arlt and Johannes Kornhuber and Thomas Kucinski and Julius Popp and Oliver Peters and Wolfgang Maier and Frank Tr{\"a}ber and Jens Wiltfang",
year = "2011",
language = "English",
volume = "27",
pages = "393--399",
journal = "J ALZHEIMERS DIS",
issn = "1387-2877",
publisher = "IOS Press",
number = "2",

}

RIS

TY - JOUR

T1 - Association of N-acetylaspartate and cerebrospinal fluid Aβ42 in dementia.

AU - Jessen, Frank

AU - Lewczuk, Piotr

AU - Gür, Okan

AU - Block, Wolfgang

AU - Ende, Gabriele

AU - Frölich, Lutz

AU - Hammen, Thilo

AU - Arlt, Sönke

AU - Kornhuber, Johannes

AU - Kucinski, Thomas

AU - Popp, Julius

AU - Peters, Oliver

AU - Maier, Wolfgang

AU - Träber, Frank

AU - Wiltfang, Jens

PY - 2011

Y1 - 2011

N2 - The interplay of amyloid and mitochondrial function is considered crucial in the pathophysiology of Alzheimer's disease (AD). We tested the association of the putative marker of mitochondrial function N-acetylaspartate (NAA) as measured by proton magnetic resonance spectroscopy within the medial temporal lobe and cerebrospinal fluid amyoid-?42 (A?42), total Tau and pTau181. 109 patients were recruited in a multicenter study (40 mild AD patients, 14 non-AD dementia patients, 29 mild cognitive impairment (MCI) AD-type patients, 26 MCI of non-AD type patients). NAA correlated with A?42 within the AD group. Since the NAA concentration is coupled to neuronal mitochondrial function, the correlation between NAA and A?42 may reflect the interaction between disrupted mitochondrial pathways and amyloid production.

AB - The interplay of amyloid and mitochondrial function is considered crucial in the pathophysiology of Alzheimer's disease (AD). We tested the association of the putative marker of mitochondrial function N-acetylaspartate (NAA) as measured by proton magnetic resonance spectroscopy within the medial temporal lobe and cerebrospinal fluid amyoid-?42 (A?42), total Tau and pTau181. 109 patients were recruited in a multicenter study (40 mild AD patients, 14 non-AD dementia patients, 29 mild cognitive impairment (MCI) AD-type patients, 26 MCI of non-AD type patients). NAA correlated with A?42 within the AD group. Since the NAA concentration is coupled to neuronal mitochondrial function, the correlation between NAA and A?42 may reflect the interaction between disrupted mitochondrial pathways and amyloid production.

M3 - SCORING: Journal article

VL - 27

SP - 393

EP - 399

JO - J ALZHEIMERS DIS

JF - J ALZHEIMERS DIS

SN - 1387-2877

IS - 2

M1 - 2

ER -