Association of N-acetylaspartate and cerebrospinal fluid Aβ42 in dementia.

  • Frank Jessen
  • Piotr Lewczuk
  • Okan Gür
  • Wolfgang Block
  • Gabriele Ende
  • Lutz Frölich
  • Thilo Hammen
  • Sönke Arlt
  • Johannes Kornhuber
  • Thomas Kucinski
  • Julius Popp
  • Oliver Peters
  • Wolfgang Maier
  • Frank Träber
  • Jens Wiltfang

Abstract

The interplay of amyloid and mitochondrial function is considered crucial in the pathophysiology of Alzheimer's disease (AD). We tested the association of the putative marker of mitochondrial function N-acetylaspartate (NAA) as measured by proton magnetic resonance spectroscopy within the medial temporal lobe and cerebrospinal fluid amyoid-?42 (A?42), total Tau and pTau181. 109 patients were recruited in a multicenter study (40 mild AD patients, 14 non-AD dementia patients, 29 mild cognitive impairment (MCI) AD-type patients, 26 MCI of non-AD type patients). NAA correlated with A?42 within the AD group. Since the NAA concentration is coupled to neuronal mitochondrial function, the correlation between NAA and A?42 may reflect the interaction between disrupted mitochondrial pathways and amyloid production.

Bibliografische Daten

OriginalspracheEnglisch
Aufsatznummer2
ISSN1387-2877
StatusVeröffentlicht - 2011
pubmed 21841259