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Assessment of subjective cognitive and emotional effects of antipsychotic drugs. Effect by defect?

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Assessment of subjective cognitive and emotional effects of antipsychotic drugs. Effect by defect? / Moritz, Steffen; Andreou, Christina; Klingberg, Stefan; Thoering, Theresa; Peters, Maarten J V.

in: NEUROPHARMACOLOGY, Jahrgang 72, 01.09.2013, S. 179-86.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Moritz, S, Andreou, C, Klingberg, S, Thoering, T & Peters, MJV 2013, 'Assessment of subjective cognitive and emotional effects of antipsychotic drugs. Effect by defect?', NEUROPHARMACOLOGY, Jg. 72, S. 179-86. https://doi.org/10.1016/j.neuropharm.2013.04.039

APA

Moritz, S., Andreou, C., Klingberg, S., Thoering, T., & Peters, M. J. V. (2013). Assessment of subjective cognitive and emotional effects of antipsychotic drugs. Effect by defect? NEUROPHARMACOLOGY, 72, 179-86. https://doi.org/10.1016/j.neuropharm.2013.04.039

Vancouver

Moritz S, Andreou C, Klingberg S, Thoering T, Peters MJV. Assessment of subjective cognitive and emotional effects of antipsychotic drugs. Effect by defect? NEUROPHARMACOLOGY. 2013 Sep 1;72:179-86. https://doi.org/10.1016/j.neuropharm.2013.04.039

Bibtex

@article{230f1b8b90844399be07b8fbb72a4d44,
title = "Assessment of subjective cognitive and emotional effects of antipsychotic drugs. Effect by defect?",
abstract = "Antipsychotic medication represents the first-line treatment for schizophrenia. While it is undisputed that antipsychotics ameliorate positive symptoms, the exact cognitive and emotional pathways through which the effect is exerted has remained unclear. The present study investigated the subjective effects of antipsychotics across various domains of cognition and emotion in both patients with psychotic symptoms and patients with other psychiatric diagnoses. A total of 69 patients with a probable history of psychosis or psychotic symptoms and 26 patients with psychiatric diagnoses other than psychosis participated in a survey conducted over the Internet. Multiple control measures aimed to secure response validity. All patients were currently or had previously been treated with antipsychotic agents. A questionnaire comprising 49 items and measuring possible effects of antipsychotics on cognition and emotion was administered. For 30 out of 49 items a clear response pattern emerged, which was similar for patients with psychotic disorders and patients with other diagnoses. Factor analysis of these items revealed three main effects of antipsychotic medication related to doubt and self-doubt, cognitive and emotional numbing, and social withdrawal. Antipsychotic treatment appears to be connected to a number of negative subjective effects on cognition and emotion. Further studies are warranted to assess how these effects impact on the patients' subjective well-being and quality of life, as well as their association with antipsychotic efficacy on one hand, and adherence rates on the other. Induction of doubt and dampening of emotion may be one reason why antipsychotics work and at the same time offer an explanation why they are experienced as rather unpleasant and are eventually discontinued by many patients.",
keywords = "Adult, Affective Symptoms, Antipsychotic Agents, Cognition Disorders, Factor Analysis, Statistical, Female, Humans, Male, Middle Aged, Psychiatric Status Rating Scales, Psychotic Disorders, Statistics as Topic",
author = "Steffen Moritz and Christina Andreou and Stefan Klingberg and Theresa Thoering and Peters, {Maarten J V}",
note = "Copyright {\textcopyright} 2013 Elsevier Ltd. All rights reserved.",
year = "2013",
month = sep,
day = "1",
doi = "10.1016/j.neuropharm.2013.04.039",
language = "English",
volume = "72",
pages = "179--86",
journal = "NEUROPHARMACOLOGY",
issn = "0028-3908",
publisher = "Elsevier Limited",

}

RIS

TY - JOUR

T1 - Assessment of subjective cognitive and emotional effects of antipsychotic drugs. Effect by defect?

AU - Moritz, Steffen

AU - Andreou, Christina

AU - Klingberg, Stefan

AU - Thoering, Theresa

AU - Peters, Maarten J V

N1 - Copyright © 2013 Elsevier Ltd. All rights reserved.

PY - 2013/9/1

Y1 - 2013/9/1

N2 - Antipsychotic medication represents the first-line treatment for schizophrenia. While it is undisputed that antipsychotics ameliorate positive symptoms, the exact cognitive and emotional pathways through which the effect is exerted has remained unclear. The present study investigated the subjective effects of antipsychotics across various domains of cognition and emotion in both patients with psychotic symptoms and patients with other psychiatric diagnoses. A total of 69 patients with a probable history of psychosis or psychotic symptoms and 26 patients with psychiatric diagnoses other than psychosis participated in a survey conducted over the Internet. Multiple control measures aimed to secure response validity. All patients were currently or had previously been treated with antipsychotic agents. A questionnaire comprising 49 items and measuring possible effects of antipsychotics on cognition and emotion was administered. For 30 out of 49 items a clear response pattern emerged, which was similar for patients with psychotic disorders and patients with other diagnoses. Factor analysis of these items revealed three main effects of antipsychotic medication related to doubt and self-doubt, cognitive and emotional numbing, and social withdrawal. Antipsychotic treatment appears to be connected to a number of negative subjective effects on cognition and emotion. Further studies are warranted to assess how these effects impact on the patients' subjective well-being and quality of life, as well as their association with antipsychotic efficacy on one hand, and adherence rates on the other. Induction of doubt and dampening of emotion may be one reason why antipsychotics work and at the same time offer an explanation why they are experienced as rather unpleasant and are eventually discontinued by many patients.

AB - Antipsychotic medication represents the first-line treatment for schizophrenia. While it is undisputed that antipsychotics ameliorate positive symptoms, the exact cognitive and emotional pathways through which the effect is exerted has remained unclear. The present study investigated the subjective effects of antipsychotics across various domains of cognition and emotion in both patients with psychotic symptoms and patients with other psychiatric diagnoses. A total of 69 patients with a probable history of psychosis or psychotic symptoms and 26 patients with psychiatric diagnoses other than psychosis participated in a survey conducted over the Internet. Multiple control measures aimed to secure response validity. All patients were currently or had previously been treated with antipsychotic agents. A questionnaire comprising 49 items and measuring possible effects of antipsychotics on cognition and emotion was administered. For 30 out of 49 items a clear response pattern emerged, which was similar for patients with psychotic disorders and patients with other diagnoses. Factor analysis of these items revealed three main effects of antipsychotic medication related to doubt and self-doubt, cognitive and emotional numbing, and social withdrawal. Antipsychotic treatment appears to be connected to a number of negative subjective effects on cognition and emotion. Further studies are warranted to assess how these effects impact on the patients' subjective well-being and quality of life, as well as their association with antipsychotic efficacy on one hand, and adherence rates on the other. Induction of doubt and dampening of emotion may be one reason why antipsychotics work and at the same time offer an explanation why they are experienced as rather unpleasant and are eventually discontinued by many patients.

KW - Adult

KW - Affective Symptoms

KW - Antipsychotic Agents

KW - Cognition Disorders

KW - Factor Analysis, Statistical

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Psychiatric Status Rating Scales

KW - Psychotic Disorders

KW - Statistics as Topic

U2 - 10.1016/j.neuropharm.2013.04.039

DO - 10.1016/j.neuropharm.2013.04.039

M3 - SCORING: Journal article

C2 - 23643756

VL - 72

SP - 179

EP - 186

JO - NEUROPHARMACOLOGY

JF - NEUROPHARMACOLOGY

SN - 0028-3908

ER -