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Application and limitations of transient liver elastography in children

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Application and limitations of transient liver elastography in children. / Goldschmidt, Imeke; Streckenbach, Carolin; Dingemann, Carmen; Pfister, Eva Doreen; di Nanni, André; Zapf, Antonia; Baumann, Ulrich.

in: J PEDIATR GASTR NUTR, Jahrgang 57, Nr. 1, 07.2013, S. 109-113.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Goldschmidt, I, Streckenbach, C, Dingemann, C, Pfister, ED, di Nanni, A, Zapf, A & Baumann, U 2013, 'Application and limitations of transient liver elastography in children', J PEDIATR GASTR NUTR, Jg. 57, Nr. 1, S. 109-113. https://doi.org/10.1097/MPG.0b013e31829206a0

APA

Goldschmidt, I., Streckenbach, C., Dingemann, C., Pfister, E. D., di Nanni, A., Zapf, A., & Baumann, U. (2013). Application and limitations of transient liver elastography in children. J PEDIATR GASTR NUTR, 57(1), 109-113. https://doi.org/10.1097/MPG.0b013e31829206a0

Vancouver

Goldschmidt I, Streckenbach C, Dingemann C, Pfister ED, di Nanni A, Zapf A et al. Application and limitations of transient liver elastography in children. J PEDIATR GASTR NUTR. 2013 Jul;57(1):109-113. https://doi.org/10.1097/MPG.0b013e31829206a0

Bibtex

@article{05730a159efc4e47bb6dc1eca5cc1ce2,
title = "Application and limitations of transient liver elastography in children",
abstract = "OBJECTIVES: Transient elastography (TE) using the FibroScan has gained popularity recently for the noninvasive diagnosis of hepatic fibrosis. Data on its use in children younger than 6 years are still scarce, and the influence of technical aspects such as probe choice and site of measurement on FibroScan results is not clear. Our study aims to clarify some technical issues concerning the use of the FibroScan in children and to deliver normal FibroScan values for reference.METHODS: TE was performed in 527 children (229 girls, ages 0.1-17.8 [median 6.0] years, including 400 healthy controls). Feasibility of different sites of measurements, paired comparison of probe settings, and pre- and postprandial measurements were systematically performed. Sedated versus unsedated measurements were compared in age- and sex-matched cohorts.RESULTS: Success rate of TE in our population was 90%, but decreased to 83% in children younger than 24 months even in ideal conditions. General anesthesia significantly increased liver stiffness in healthy children (5.4 [3-9.5] vs 4.2 [2.8-8.15] kPa; P < 0.01). Probe choice equally influenced results in paired comparisons (S1 5.5 [3.5-17.9] vs S2 4.8 [2.1-15.4] kPa; P < 0.01), as did food intake (5.9 [3.6-75] vs 5.4 [3.6-63.9] kPa; P = 0.015). Inter- and intraobserver agreements were good. Normal liver stiffness was 4.5 (2.5-8.9) kPa and did not vary significantly with age or sex.CONCLUSIONS: TE is feasible even in extremely young children, but confounding influences on test results such as probe choice, sedation, or food intake need to be taken into account when interpreting results.",
keywords = "Age Factors, Anesthesia, General, Child, Child, Preschool, Cohort Studies, Elasticity Imaging Techniques, Fasting, Feasibility Studies, Female, Humans, Infant, Liver, Liver Cirrhosis, Liver Diseases, Male, Postprandial Period, Practice Guidelines as Topic, Reference Values, Reproducibility of Results, Comparative Study, Journal Article, Research Support, Non-U.S. Gov't",
author = "Imeke Goldschmidt and Carolin Streckenbach and Carmen Dingemann and Pfister, {Eva Doreen} and {di Nanni}, Andr{\'e} and Antonia Zapf and Ulrich Baumann",
year = "2013",
month = jul,
doi = "10.1097/MPG.0b013e31829206a0",
language = "English",
volume = "57",
pages = "109--113",
journal = "J PEDIATR GASTR NUTR",
issn = "0277-2116",
publisher = "Lippincott Williams and Wilkins",
number = "1",

}

RIS

TY - JOUR

T1 - Application and limitations of transient liver elastography in children

AU - Goldschmidt, Imeke

AU - Streckenbach, Carolin

AU - Dingemann, Carmen

AU - Pfister, Eva Doreen

AU - di Nanni, André

AU - Zapf, Antonia

AU - Baumann, Ulrich

PY - 2013/7

Y1 - 2013/7

N2 - OBJECTIVES: Transient elastography (TE) using the FibroScan has gained popularity recently for the noninvasive diagnosis of hepatic fibrosis. Data on its use in children younger than 6 years are still scarce, and the influence of technical aspects such as probe choice and site of measurement on FibroScan results is not clear. Our study aims to clarify some technical issues concerning the use of the FibroScan in children and to deliver normal FibroScan values for reference.METHODS: TE was performed in 527 children (229 girls, ages 0.1-17.8 [median 6.0] years, including 400 healthy controls). Feasibility of different sites of measurements, paired comparison of probe settings, and pre- and postprandial measurements were systematically performed. Sedated versus unsedated measurements were compared in age- and sex-matched cohorts.RESULTS: Success rate of TE in our population was 90%, but decreased to 83% in children younger than 24 months even in ideal conditions. General anesthesia significantly increased liver stiffness in healthy children (5.4 [3-9.5] vs 4.2 [2.8-8.15] kPa; P < 0.01). Probe choice equally influenced results in paired comparisons (S1 5.5 [3.5-17.9] vs S2 4.8 [2.1-15.4] kPa; P < 0.01), as did food intake (5.9 [3.6-75] vs 5.4 [3.6-63.9] kPa; P = 0.015). Inter- and intraobserver agreements were good. Normal liver stiffness was 4.5 (2.5-8.9) kPa and did not vary significantly with age or sex.CONCLUSIONS: TE is feasible even in extremely young children, but confounding influences on test results such as probe choice, sedation, or food intake need to be taken into account when interpreting results.

AB - OBJECTIVES: Transient elastography (TE) using the FibroScan has gained popularity recently for the noninvasive diagnosis of hepatic fibrosis. Data on its use in children younger than 6 years are still scarce, and the influence of technical aspects such as probe choice and site of measurement on FibroScan results is not clear. Our study aims to clarify some technical issues concerning the use of the FibroScan in children and to deliver normal FibroScan values for reference.METHODS: TE was performed in 527 children (229 girls, ages 0.1-17.8 [median 6.0] years, including 400 healthy controls). Feasibility of different sites of measurements, paired comparison of probe settings, and pre- and postprandial measurements were systematically performed. Sedated versus unsedated measurements were compared in age- and sex-matched cohorts.RESULTS: Success rate of TE in our population was 90%, but decreased to 83% in children younger than 24 months even in ideal conditions. General anesthesia significantly increased liver stiffness in healthy children (5.4 [3-9.5] vs 4.2 [2.8-8.15] kPa; P < 0.01). Probe choice equally influenced results in paired comparisons (S1 5.5 [3.5-17.9] vs S2 4.8 [2.1-15.4] kPa; P < 0.01), as did food intake (5.9 [3.6-75] vs 5.4 [3.6-63.9] kPa; P = 0.015). Inter- and intraobserver agreements were good. Normal liver stiffness was 4.5 (2.5-8.9) kPa and did not vary significantly with age or sex.CONCLUSIONS: TE is feasible even in extremely young children, but confounding influences on test results such as probe choice, sedation, or food intake need to be taken into account when interpreting results.

KW - Age Factors

KW - Anesthesia, General

KW - Child

KW - Child, Preschool

KW - Cohort Studies

KW - Elasticity Imaging Techniques

KW - Fasting

KW - Feasibility Studies

KW - Female

KW - Humans

KW - Infant

KW - Liver

KW - Liver Cirrhosis

KW - Liver Diseases

KW - Male

KW - Postprandial Period

KW - Practice Guidelines as Topic

KW - Reference Values

KW - Reproducibility of Results

KW - Comparative Study

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1097/MPG.0b013e31829206a0

DO - 10.1097/MPG.0b013e31829206a0

M3 - SCORING: Journal article

C2 - 23539048

VL - 57

SP - 109

EP - 113

JO - J PEDIATR GASTR NUTR

JF - J PEDIATR GASTR NUTR

SN - 0277-2116

IS - 1

ER -