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Accumulation and local proliferation of antigen-specific CD4+ T cells in antigen-bearing tissue

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Accumulation and local proliferation of antigen-specific CD4+ T cells in antigen-bearing tissue. / Doebis, Cornelia; Menning, Astrid; Neumann, Katrin; Ghani, Saeed; Schlawe, Kerstin; Lauer, Uta; Hamann, Alf; Huehn, Jochen; Syrbe, Uta.

in: IMMUNOL CELL BIOL, Jahrgang 89, Nr. 4, 05.2011, S. 566-72.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Doebis, C, Menning, A, Neumann, K, Ghani, S, Schlawe, K, Lauer, U, Hamann, A, Huehn, J & Syrbe, U 2011, 'Accumulation and local proliferation of antigen-specific CD4+ T cells in antigen-bearing tissue', IMMUNOL CELL BIOL, Jg. 89, Nr. 4, S. 566-72. https://doi.org/10.1038/icb.2010.128

APA

Doebis, C., Menning, A., Neumann, K., Ghani, S., Schlawe, K., Lauer, U., Hamann, A., Huehn, J., & Syrbe, U. (2011). Accumulation and local proliferation of antigen-specific CD4+ T cells in antigen-bearing tissue. IMMUNOL CELL BIOL, 89(4), 566-72. https://doi.org/10.1038/icb.2010.128

Vancouver

Doebis C, Menning A, Neumann K, Ghani S, Schlawe K, Lauer U et al. Accumulation and local proliferation of antigen-specific CD4+ T cells in antigen-bearing tissue. IMMUNOL CELL BIOL. 2011 Mai;89(4):566-72. https://doi.org/10.1038/icb.2010.128

Bibtex

@article{dcc3273128c44e2ba85c1d0c636de248,
title = "Accumulation and local proliferation of antigen-specific CD4+ T cells in antigen-bearing tissue",
abstract = "Although activation and subsequent expansion of naive CD4(+) T cells within lymph nodes is well characterized, the fate of T effector cells activated within peripheral tissues during secondary reactions is poorly defined. Therefore, we studied the recruitment, proliferation and egress of antigen-specific Th1 effector cells in comparison with nonspecific Th1 cells throughout a delayed-type hypersensitivity reaction (DTH). Although we observed a high turnover of Th1 effector cells with unspecific high-rate recruitment and CCR7-dependent egress from the inflamed tissue in the early, acute DTH phase, a strong, selective accumulation of antigen-specific T cells occurred during the chronic, late DTH phase. This was mainly based on local proliferation of CD4(+) effector cells within the DTH tissue and concomitant retention. Considering the strong CCR7-dependent Th cell egress found in this model, the reduced CCR7 expression on antigen-specific T cells isolated from late-phase DTH tissue most likely contributes to the retention of these cells within the tissue. Thus, peripheral tissues can support not only the proliferation of CD8(+) T cells, as recently shown, but also that of CD4(+) T effector cells, forming a pool of tissue-resident T cells.",
keywords = "Animals, Antigens, CD4-Positive T-Lymphocytes, Cell Proliferation, Epitopes, Hypersensitivity, Delayed, Inflammation, Mice, Mice, Inbred BALB C, Receptors, CCR7",
author = "Cornelia Doebis and Astrid Menning and Katrin Neumann and Saeed Ghani and Kerstin Schlawe and Uta Lauer and Alf Hamann and Jochen Huehn and Uta Syrbe",
year = "2011",
month = may,
doi = "10.1038/icb.2010.128",
language = "English",
volume = "89",
pages = "566--72",
journal = "IMMUNOL CELL BIOL",
issn = "0818-9641",
publisher = "John Wiley & Sons",
number = "4",

}

RIS

TY - JOUR

T1 - Accumulation and local proliferation of antigen-specific CD4+ T cells in antigen-bearing tissue

AU - Doebis, Cornelia

AU - Menning, Astrid

AU - Neumann, Katrin

AU - Ghani, Saeed

AU - Schlawe, Kerstin

AU - Lauer, Uta

AU - Hamann, Alf

AU - Huehn, Jochen

AU - Syrbe, Uta

PY - 2011/5

Y1 - 2011/5

N2 - Although activation and subsequent expansion of naive CD4(+) T cells within lymph nodes is well characterized, the fate of T effector cells activated within peripheral tissues during secondary reactions is poorly defined. Therefore, we studied the recruitment, proliferation and egress of antigen-specific Th1 effector cells in comparison with nonspecific Th1 cells throughout a delayed-type hypersensitivity reaction (DTH). Although we observed a high turnover of Th1 effector cells with unspecific high-rate recruitment and CCR7-dependent egress from the inflamed tissue in the early, acute DTH phase, a strong, selective accumulation of antigen-specific T cells occurred during the chronic, late DTH phase. This was mainly based on local proliferation of CD4(+) effector cells within the DTH tissue and concomitant retention. Considering the strong CCR7-dependent Th cell egress found in this model, the reduced CCR7 expression on antigen-specific T cells isolated from late-phase DTH tissue most likely contributes to the retention of these cells within the tissue. Thus, peripheral tissues can support not only the proliferation of CD8(+) T cells, as recently shown, but also that of CD4(+) T effector cells, forming a pool of tissue-resident T cells.

AB - Although activation and subsequent expansion of naive CD4(+) T cells within lymph nodes is well characterized, the fate of T effector cells activated within peripheral tissues during secondary reactions is poorly defined. Therefore, we studied the recruitment, proliferation and egress of antigen-specific Th1 effector cells in comparison with nonspecific Th1 cells throughout a delayed-type hypersensitivity reaction (DTH). Although we observed a high turnover of Th1 effector cells with unspecific high-rate recruitment and CCR7-dependent egress from the inflamed tissue in the early, acute DTH phase, a strong, selective accumulation of antigen-specific T cells occurred during the chronic, late DTH phase. This was mainly based on local proliferation of CD4(+) effector cells within the DTH tissue and concomitant retention. Considering the strong CCR7-dependent Th cell egress found in this model, the reduced CCR7 expression on antigen-specific T cells isolated from late-phase DTH tissue most likely contributes to the retention of these cells within the tissue. Thus, peripheral tissues can support not only the proliferation of CD8(+) T cells, as recently shown, but also that of CD4(+) T effector cells, forming a pool of tissue-resident T cells.

KW - Animals

KW - Antigens

KW - CD4-Positive T-Lymphocytes

KW - Cell Proliferation

KW - Epitopes

KW - Hypersensitivity, Delayed

KW - Inflammation

KW - Mice

KW - Mice, Inbred BALB C

KW - Receptors, CCR7

U2 - 10.1038/icb.2010.128

DO - 10.1038/icb.2010.128

M3 - SCORING: Journal article

C2 - 21060322

VL - 89

SP - 566

EP - 572

JO - IMMUNOL CELL BIOL

JF - IMMUNOL CELL BIOL

SN - 0818-9641

IS - 4

ER -