A novel membrane-permeant cADPR antagonist modified in the pyrophosphate bridge.
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A novel membrane-permeant cADPR antagonist modified in the pyrophosphate bridge. / Qi, N; Jung, Kathrin; Wang, M; Na, L X; Yang, Z J; Zhang, L R; Guse, Andreas H.; Zhang, L H.
in: CHEM COMMUN, Jahrgang 47, Nr. 33, 33, 2011, S. 9462-9464.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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TY - JOUR
T1 - A novel membrane-permeant cADPR antagonist modified in the pyrophosphate bridge.
AU - Qi, N
AU - Jung, Kathrin
AU - Wang, M
AU - Na, L X
AU - Yang, Z J
AU - Zhang, L R
AU - Guse, Andreas H.
AU - Zhang, L H
PY - 2011
Y1 - 2011
N2 - A concise method for the formation of cyclopyrophosphate of cIDPRE as well as sulfur and selenium-substituted pyrophosphate cIDPRE analogues (P(1)(S)-cIDPRE, P(1)(Se)-cIDPRE, P(2)(S)-cIDPRE and P(2)(Se)-cIDPRE) was reported and one of the P(S)-diastereoisomers, P(1)(S)-cIDPRE-1, is a novel membrane-permeant cADPR antagonist.
AB - A concise method for the formation of cyclopyrophosphate of cIDPRE as well as sulfur and selenium-substituted pyrophosphate cIDPRE analogues (P(1)(S)-cIDPRE, P(1)(Se)-cIDPRE, P(2)(S)-cIDPRE and P(2)(Se)-cIDPRE) was reported and one of the P(S)-diastereoisomers, P(1)(S)-cIDPRE-1, is a novel membrane-permeant cADPR antagonist.
KW - Calcium Channel Blockers/chemical synthesis/chemistry
KW - Cyclic ADP-Ribose/analogs & derivatives
KW - Diphosphates/chemistry
KW - Inosine Monophosphate/analogs & derivatives/chemical synthesis/chemistry
KW - Molecular Conformation
KW - Ryanodine Receptor Calcium Release Channel/chemistry/metabolism
KW - Selenium/chemistry
KW - Stereoisomerism
KW - Sulfur/chemistry
KW - Calcium Channel Blockers/chemical synthesis/chemistry
KW - Cyclic ADP-Ribose/analogs & derivatives
KW - Diphosphates/chemistry
KW - Inosine Monophosphate/analogs & derivatives/chemical synthesis/chemistry
KW - Molecular Conformation
KW - Ryanodine Receptor Calcium Release Channel/chemistry/metabolism
KW - Selenium/chemistry
KW - Stereoisomerism
KW - Sulfur/chemistry
M3 - SCORING: Journal article
VL - 47
SP - 9462
EP - 9464
JO - CHEM COMMUN
JF - CHEM COMMUN
SN - 1359-7345
IS - 33
M1 - 33
ER -