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8p deletions in renal cell carcinoma are associated with unfavorable tumor features and poor overall survival

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8p deletions in renal cell carcinoma are associated with unfavorable tumor features and poor overall survival. / Eichenauer, Till; Bannenberg, David C; Kluth, Martina; Wittmer, Corinna; Büscheck, Franziska; Möller, Katharina; Dum, David; Fraune, Christoph; Hube-Magg, Claudia; Möller-Koop, Christina; Dahlem, Roland; Fisch, Margit; Rink, Michael; Riechardt, Silke; Tsourlakis, Maria Christina; Bernreuther, Christian; Minner, Sarah; Simon, Ronald; Sauter, Guido; Wilczak, Waldemar; Clauditz, Till S.

in: UROL ONCOL-SEMIN ORI, Jahrgang 38, Nr. 2, 02.2020, S. 43.e13-43.e20.

Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung

Harvard

Eichenauer, T, Bannenberg, DC, Kluth, M, Wittmer, C, Büscheck, F, Möller, K, Dum, D, Fraune, C, Hube-Magg, C, Möller-Koop, C, Dahlem, R, Fisch, M, Rink, M, Riechardt, S, Tsourlakis, MC, Bernreuther, C, Minner, S, Simon, R, Sauter, G, Wilczak, W & Clauditz, TS 2020, '8p deletions in renal cell carcinoma are associated with unfavorable tumor features and poor overall survival', UROL ONCOL-SEMIN ORI, Jg. 38, Nr. 2, S. 43.e13-43.e20. https://doi.org/10.1016/j.urolonc.2019.09.024

APA

Eichenauer, T., Bannenberg, D. C., Kluth, M., Wittmer, C., Büscheck, F., Möller, K., Dum, D., Fraune, C., Hube-Magg, C., Möller-Koop, C., Dahlem, R., Fisch, M., Rink, M., Riechardt, S., Tsourlakis, M. C., Bernreuther, C., Minner, S., Simon, R., Sauter, G., ... Clauditz, T. S. (2020). 8p deletions in renal cell carcinoma are associated with unfavorable tumor features and poor overall survival. UROL ONCOL-SEMIN ORI, 38(2), 43.e13-43.e20. https://doi.org/10.1016/j.urolonc.2019.09.024

Vancouver

Eichenauer T, Bannenberg DC, Kluth M, Wittmer C, Büscheck F, Möller K et al. 8p deletions in renal cell carcinoma are associated with unfavorable tumor features and poor overall survival. UROL ONCOL-SEMIN ORI. 2020 Feb;38(2):43.e13-43.e20. https://doi.org/10.1016/j.urolonc.2019.09.024

Bibtex

@article{e66b7dd126274370b20f57fe8a8888ab,
title = "8p deletions in renal cell carcinoma are associated with unfavorable tumor features and poor overall survival",
abstract = "BACKGROUND AND METHODS: 8p deletions are common in renal cell carcinoma. To study their prognostic impact and association with kidney cancer phenotype, a tissue microarray with 1,809 cancers was analyzed by fluorescence in situ hybridization for 8p21 copy numbers.RESULTS: One thousand four hundred and seventy four interpretable tumors showed substantial differences between renal cancer subtypes. That 8p deletion was only seen in 1 (0.5%) of 216 papillary carcinomas underscores the biologic uniqueness of papillary kidney cancer, which is also defined by a highly distinct morphology. 8p deletions were found in 13.2% of 976 clear cell carcinomas, 7.8% of 77 chromophobe carcinomas, 0.8% of 119 oncocytomas, but also in several rare tumor entities including 1 of 4 collecting duct cancers, 1 of 3 multilocular cystic clear cell renal cell neoplasm of low malignancy, 2 of 10 Xp11.2 translocation cancers, 3 of 18 not otherwise specified carcinomas, and 1 analyzed medullary carcinoma. In clear cell carcinomas, 8p deletions were significantly associated with higher International Society of Urologic Pathologists (ISUP) grading (P = 0.0014), Fuhrman (P = 0.0003) and Thoenes grade (P = 0.0033), advanced tumor stage (P = 0.0002), large tumor diameter (P = 0.0019), distant metastases (P = 0.0183), overall survival (P = 0.0394), and recurrence free survival (P < 0.0001). In multivariate analysis, the prognostic role of 8p deletions was not independent of established clinic-pathological parameters. In conclusion, 8p deletions are strongly linked to tumor aggressiveness in clear cell kidney cancer.CONCLUSIONS: Because 8p deletions are easy to measure by fluorescence in situ hybridization, 8p deletion assessment, most likely in combination with other parameters, may have a role in future prognosis assessment in clear cell kidney cancer.",
author = "Till Eichenauer and Bannenberg, {David C} and Martina Kluth and Corinna Wittmer and Franziska B{\"u}scheck and Katharina M{\"o}ller and David Dum and Christoph Fraune and Claudia Hube-Magg and Christina M{\"o}ller-Koop and Roland Dahlem and Margit Fisch and Michael Rink and Silke Riechardt and Tsourlakis, {Maria Christina} and Christian Bernreuther and Sarah Minner and Ronald Simon and Guido Sauter and Waldemar Wilczak and Clauditz, {Till S}",
note = "Copyright {\textcopyright} 2019 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2020",
month = feb,
doi = "10.1016/j.urolonc.2019.09.024",
language = "English",
volume = "38",
pages = "43.e13--43.e20",
journal = "UROL ONCOL-SEMIN ORI",
issn = "1078-1439",
publisher = "Elsevier Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - 8p deletions in renal cell carcinoma are associated with unfavorable tumor features and poor overall survival

AU - Eichenauer, Till

AU - Bannenberg, David C

AU - Kluth, Martina

AU - Wittmer, Corinna

AU - Büscheck, Franziska

AU - Möller, Katharina

AU - Dum, David

AU - Fraune, Christoph

AU - Hube-Magg, Claudia

AU - Möller-Koop, Christina

AU - Dahlem, Roland

AU - Fisch, Margit

AU - Rink, Michael

AU - Riechardt, Silke

AU - Tsourlakis, Maria Christina

AU - Bernreuther, Christian

AU - Minner, Sarah

AU - Simon, Ronald

AU - Sauter, Guido

AU - Wilczak, Waldemar

AU - Clauditz, Till S

N1 - Copyright © 2019 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2020/2

Y1 - 2020/2

N2 - BACKGROUND AND METHODS: 8p deletions are common in renal cell carcinoma. To study their prognostic impact and association with kidney cancer phenotype, a tissue microarray with 1,809 cancers was analyzed by fluorescence in situ hybridization for 8p21 copy numbers.RESULTS: One thousand four hundred and seventy four interpretable tumors showed substantial differences between renal cancer subtypes. That 8p deletion was only seen in 1 (0.5%) of 216 papillary carcinomas underscores the biologic uniqueness of papillary kidney cancer, which is also defined by a highly distinct morphology. 8p deletions were found in 13.2% of 976 clear cell carcinomas, 7.8% of 77 chromophobe carcinomas, 0.8% of 119 oncocytomas, but also in several rare tumor entities including 1 of 4 collecting duct cancers, 1 of 3 multilocular cystic clear cell renal cell neoplasm of low malignancy, 2 of 10 Xp11.2 translocation cancers, 3 of 18 not otherwise specified carcinomas, and 1 analyzed medullary carcinoma. In clear cell carcinomas, 8p deletions were significantly associated with higher International Society of Urologic Pathologists (ISUP) grading (P = 0.0014), Fuhrman (P = 0.0003) and Thoenes grade (P = 0.0033), advanced tumor stage (P = 0.0002), large tumor diameter (P = 0.0019), distant metastases (P = 0.0183), overall survival (P = 0.0394), and recurrence free survival (P < 0.0001). In multivariate analysis, the prognostic role of 8p deletions was not independent of established clinic-pathological parameters. In conclusion, 8p deletions are strongly linked to tumor aggressiveness in clear cell kidney cancer.CONCLUSIONS: Because 8p deletions are easy to measure by fluorescence in situ hybridization, 8p deletion assessment, most likely in combination with other parameters, may have a role in future prognosis assessment in clear cell kidney cancer.

AB - BACKGROUND AND METHODS: 8p deletions are common in renal cell carcinoma. To study their prognostic impact and association with kidney cancer phenotype, a tissue microarray with 1,809 cancers was analyzed by fluorescence in situ hybridization for 8p21 copy numbers.RESULTS: One thousand four hundred and seventy four interpretable tumors showed substantial differences between renal cancer subtypes. That 8p deletion was only seen in 1 (0.5%) of 216 papillary carcinomas underscores the biologic uniqueness of papillary kidney cancer, which is also defined by a highly distinct morphology. 8p deletions were found in 13.2% of 976 clear cell carcinomas, 7.8% of 77 chromophobe carcinomas, 0.8% of 119 oncocytomas, but also in several rare tumor entities including 1 of 4 collecting duct cancers, 1 of 3 multilocular cystic clear cell renal cell neoplasm of low malignancy, 2 of 10 Xp11.2 translocation cancers, 3 of 18 not otherwise specified carcinomas, and 1 analyzed medullary carcinoma. In clear cell carcinomas, 8p deletions were significantly associated with higher International Society of Urologic Pathologists (ISUP) grading (P = 0.0014), Fuhrman (P = 0.0003) and Thoenes grade (P = 0.0033), advanced tumor stage (P = 0.0002), large tumor diameter (P = 0.0019), distant metastases (P = 0.0183), overall survival (P = 0.0394), and recurrence free survival (P < 0.0001). In multivariate analysis, the prognostic role of 8p deletions was not independent of established clinic-pathological parameters. In conclusion, 8p deletions are strongly linked to tumor aggressiveness in clear cell kidney cancer.CONCLUSIONS: Because 8p deletions are easy to measure by fluorescence in situ hybridization, 8p deletion assessment, most likely in combination with other parameters, may have a role in future prognosis assessment in clear cell kidney cancer.

U2 - 10.1016/j.urolonc.2019.09.024

DO - 10.1016/j.urolonc.2019.09.024

M3 - SCORING: Journal article

C2 - 31757738

VL - 38

SP - 43.e13-43.e20

JO - UROL ONCOL-SEMIN ORI

JF - UROL ONCOL-SEMIN ORI

SN - 1078-1439

IS - 2

ER -