5-HTTLPR and COMTval158met genotype gate amygdala reactivity and habituation
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5-HTTLPR and COMTval158met genotype gate amygdala reactivity and habituation. / Lonsdorf, Tina B; Golkar, Armita; Lindstöm, Kara M; Fransson, Peter; Schalling, Martin; Ohman, Arne; Ingvar, Martin.
in: BIOL PSYCHOL, Jahrgang 87, Nr. 1, 01.04.2011, S. 106-12.Publikationen: SCORING: Beitrag in Fachzeitschrift/Zeitung › SCORING: Zeitschriftenaufsatz › Forschung › Begutachtung
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T1 - 5-HTTLPR and COMTval158met genotype gate amygdala reactivity and habituation
AU - Lonsdorf, Tina B
AU - Golkar, Armita
AU - Lindstöm, Kara M
AU - Fransson, Peter
AU - Schalling, Martin
AU - Ohman, Arne
AU - Ingvar, Martin
N1 - Copyright © 2011 Elsevier B.V. All rights reserved.
PY - 2011/4/1
Y1 - 2011/4/1
N2 - Amygdala reactivity is a heritable trait, potentiated in affective disorders and associated with both the 5-HTTLPR and the COMTval158met polymorphism. Fifty-four healthy volunteers selected a priori based on gender and 5-HTTLPR/rs25531 and COMTval158met genotypes performed a passive viewing task of angry facial expressions using fMRI. Amygdala reactivity and habituation were investigated using the a priori anatomical region of interest (ROI) approach. Furthermore, salivary cortisol and skin conductance responses were recorded. We observed an effect of 5-HTTLPR on right amygdala reactivity (s-carrier>l/l) and COMTval158met on left amygdala reactivity (met/met>val-carrier). We provide preliminary evidence that different amygdala habituation curves may partly underlie the differences between 5-HTTLPR and not COMT genotype groups. Further, exploratory analyses find no evidence for additive or interaction effects. Our results support that 5-HTTLPR s-carriers and COMT met/met carriers may be more sensitive to the detection of biologically and socially relevant information and suggest a mechanism behind this for the 5-HTTLPR.
AB - Amygdala reactivity is a heritable trait, potentiated in affective disorders and associated with both the 5-HTTLPR and the COMTval158met polymorphism. Fifty-four healthy volunteers selected a priori based on gender and 5-HTTLPR/rs25531 and COMTval158met genotypes performed a passive viewing task of angry facial expressions using fMRI. Amygdala reactivity and habituation were investigated using the a priori anatomical region of interest (ROI) approach. Furthermore, salivary cortisol and skin conductance responses were recorded. We observed an effect of 5-HTTLPR on right amygdala reactivity (s-carrier>l/l) and COMTval158met on left amygdala reactivity (met/met>val-carrier). We provide preliminary evidence that different amygdala habituation curves may partly underlie the differences between 5-HTTLPR and not COMT genotype groups. Further, exploratory analyses find no evidence for additive or interaction effects. Our results support that 5-HTTLPR s-carriers and COMT met/met carriers may be more sensitive to the detection of biologically and socially relevant information and suggest a mechanism behind this for the 5-HTTLPR.
KW - Adult
KW - Amygdala
KW - Catechol O-Methyltransferase
KW - Face
KW - Female
KW - Galvanic Skin Response
KW - Genotype
KW - Habituation, Psychophysiologic
KW - Humans
KW - Hydrocortisone
KW - Image Processing, Computer-Assisted
KW - Magnetic Resonance Imaging
KW - Male
KW - Methionine
KW - Oxygen
KW - Photic Stimulation
KW - Polymorphism, Single Nucleotide
KW - Saliva
KW - Serotonin Plasma Membrane Transport Proteins
KW - Valine
KW - Young Adult
U2 - 10.1016/j.biopsycho.2011.02.014
DO - 10.1016/j.biopsycho.2011.02.014
M3 - SCORING: Journal article
C2 - 21356267
VL - 87
SP - 106
EP - 112
JO - BIOL PSYCHOL
JF - BIOL PSYCHOL
SN - 0301-0511
IS - 1
ER -